An in situ injectable temperature-sensitive response water-soluble chitosan composite hydrogel for lacrimal embolism, its preparation method and application

A technology of water-soluble chitosan and composite hydrogel, which can be applied to medical preparations without active ingredients, medical preparations containing active ingredients, and drug combinations, etc. Reduce the patient's compliance with treatment, increase the patient's economic burden, etc., to achieve the effect of low operation cost, low toxicity and side effects, and low cost
CN109045063BActive Publication Date: 2021-01-26陕西靓双瞳医疗科技发展有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
陕西靓双瞳医疗科技发展有限公司
Publication Date
2021-01-26

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Abstract

The invention discloses an in-situ injectable temperature-sensitive response water-soluble chitosan composite hydrogel for lacrimal duct embolism, a preparation method and application thereof, and belongs to the technical field of medical products. The composite hydrogel of the present invention is a liquid sol with fluidity at room temperature, and the sol is placed into the lacrimal duct of a human body through punctum injection. Utilizing the gel phase transition characteristic of the sol that is sensitive to body temperature, the in-situ gel embolization of the sol in the lacrimal duct is realized, and a small amount of tear fluid secreted by the affected eye is retained in the orbit, so as to achieve the purpose of keeping the ocular surface moist for a long time. Using the body temperature responsiveness of water-soluble chitosan and sodium glycerophosphate complex, and adding alginate and calcium chloride to adjust its mechanical properties, sol-gel phase transition time, mechanical strength, etc., the operation is simple and the reaction The condition is mild, the cost is low, the biocompatibility is good, the trauma is small, and the lacrimal duct of any shape and size can be filled, and it has a good relief effect on patients with dry eye.
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Description

Technical field

[0001] The invention belongs to the technical field of medical products, and relates to an in-situ injectable temperature-sensitive and responsive water-soluble chitosan composite hydrogel for lacrimal duct embolization, and a preparation method and application thereof.Background technique

[0002] Dry eye disease (dry eye disease) is an eye disease caused by congenital lacrimal gland hypoplasia, trachoma, corneal sclerosis and other causes, such as decreased tear film stability and abnormal tear quality or quantity. The essence of the disease is the decrease in the number and density of goblet cells in the tear film, which causes changes in the quality or quantity of tear secretion. The main clinical symptoms are dry eyes, itching, etc. The long-term accumulation of symptoms will cause deep-seated lesions in the patient's cornea and conjunctiva, which may cause vision loss in severe cases. Epidemiological survey results show that the prevalence of dry eye disease is relat...

Claims

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