Tissue engineering composite stent for osteochondral repair and preparation method thereof

Abstract

The invention discloses a tissue engineering composite stent for osteochondral repair. The stent is obtained by adding a cell suspension dropwise to a cell-porous material composite and then conducting gelating. The cell-adhesive porous stent is a porous stent containing collagen, gelatin, fibronectin or cell-adhesive polypeptide, and all the materials are commonly used biomedical materials with good biocompatibility and are biodegradable in vivo. Hydrogel macromonomer sodium alginate, hyaluronic acid, agarose and chitosan also have good biocompatibility and biodegradability. Polyethylene glycol diacrylate is a biological material that is bio-inert and can be used in vivo, does not cause blood clotting reaction in vivo and is excreted through the kidneys. The composite stent can be used asa bone-cartilage tissue engineering / repair stent material, and has beneficial technical effects and wide application prospects.

Description

technical field

[0001] The invention belongs to the field of macromolecule materials, and in particular relates to a tissue engineering composite support for osteochondral repair and a preparation method thereof. Background technique

[0002] Full-thickness articular cartilage damage is often accompanied by subchondral bone sclerosis or cystic degeneration. In the later stage of osteonecrosis, the articular cartilage structure can be destroyed due to the collapse of the articular surface. All of them show simultaneous destruction of osteochondral bone. Currently, it is difficult to treat this kind of cartilage combined with subchondral bone injury, and the effect is not good. The development of tissue engineering in the past ten years has provided feasible measures for osteochondral repair. When simple tissue engineered cartilage is used to repair joint osteochondral defects, the healing interface between the graft body and the transplant bed is the integration of the carti...

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