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Preparation method of nanoparticles with magnetic targeting function and slow-release controllable photothermal-magnetothermal-anticancer drug synergy

A technology of nano-particles and anti-cancer drugs, which is applied in the field of preparation of nano-particles with controlled-release photothermal-magneto-thermal-anticancer drug synergy, can solve the problems of limited application of fluorinated graphene, poor biocompatibility, and cumbersome synthesis steps, etc., to achieve the effect of improving bioavailability, convenient operation, and simple experimental process

Active Publication Date: 2019-01-04
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, poor biocompatibility due to its hydrophobicity, harsh preparation conditions and tedious synthesis steps severely limit the application of fluorinated graphene in the biological field.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] 1) Mix 9 g of potassium hydroxide powder and 3 g of graphite fluoride uniformly, and heat to 250 °C for 1.5 h under the protection of helium. After the reaction was cooled to room temperature, the mixture was poured into deionized water and sonicated for 2 h. After centrifugation at 3000 r / m for 5-10 min, the upper layer solution was removed, filtered, and the sample was washed with sodium bicarbonate and deionized water several times until the filtrate was neutral, and the obtained sample was dried at 60 °C for 10 h.

[0045] 2) The above dried sample was added to 18 mL of concentrated sulfuric acid, ultrasonicated for 0.5 h, and then heated to 70 °C, then 2.5 g of potassium persulfate and 2.5 g of phosphorus pentoxide were added, and stirred for 3 h. Then add 500 mL of ionized water, let it stand overnight, remove the supernatant, wash and filter with deionized water, and dry at 60 °C for 10 h to obtain the pretreated sample.

[0046] 3) Add the above-mentioned pretr...

Embodiment 2

[0059] 1) Mix 18 g of potassium hydroxide powder and 4 g of graphite fluoride uniformly, and heat to 280 °C for 2 h under the protection of helium. After the reaction was cooled to room temperature, the mixture was poured into deionized water and sonicated for 3 h. After centrifuging at 5000 r / m for 10 min, remove the upper layer solution, filter, wash the sample with sodium bicarbonate and deionized water several times until the filtrate is neutral, and dry the obtained sample at 60 °C for 10-12 h.

[0060] 2) The above dried sample was added to 20 mL of concentrated sulfuric acid, ultrasonicated for 0.5 h, and then heated to 90 °C, then 3 g of potassium persulfate and 3 g of phosphorus pentoxide were added, and stirred for 4 h. Add 550 mL of deionized water, let it stand overnight, remove the supernatant, wash and filter with deionized water, and dry at 60 °C for 12 h to obtain the pretreated sample.

[0061] 3) Add the above-mentioned pretreated sample to the mixed solutio...

Embodiment 3

[0074] 1) Mix 12 g of potassium hydroxide powder and 3.5 g of graphite fluoride uniformly, and heat to 265 °C for 1.5 h under the protection of helium. After the reaction was cooled to room temperature, the mixture was poured into deionized water and sonicated for 2.5 h. Centrifuge at 4000 r / m for 7 min, remove the upper layer solution, filter, wash the sample with sodium bicarbonate and deionized water several times until the filtrate is neutral, and dry the obtained sample at 60 °C for 11 h.

[0075] 2) The above-mentioned dried sample was added to 19 mL of concentrated sulfuric acid, ultrasonicated for 0.5 h, and then heated to 80 °C, then 2.75 g of potassium persulfate and 2.75 g of phosphorus pentoxide were added, and stirred for 3-4 h. Add 525 mL of deionized water, let it stand overnight, remove the supernatant, wash and filter with deionized water, and dry at 60 °C for 11 h to obtain the pretreated sample.

[0076] 3) Add the above-mentioned pretreated sample to the m...

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Abstract

The invention relates to the field of pharmacy, in particular to a preparation method of nanoparticles with a magnetic targeting function and slow-release controllable photothermal-magnetothermal-anticancer drug synergy. Graphite fluoride is used as a raw material to prepare part of graphene fluoride first; iron oxide is modified with an amino group; the graphene fluoride is then modified with themodified iron oxide; the anticancer drug mitoxantrone is then loaded to the modified graphene fluoride is loaded to obtain iron oxide-graphene fluoride-mitoxantrone nanoparticles; with the nanomaterial serving as a core material and the temperature-sensitive materials, polyvinylpyrrolidone and Arabic gum, as a wall material, the nanoparticles with the magnetic targeting function and slow-releasecontrollable photothermal-magnetothermal-anticancer drug synergy are prepared. The nanoparticles can target at an affected part under the action of a magnetic field, can raise the ambient temperaturethrough magnetic heat and optical heat under orthogonal magnetic field and near-infrared irradiation, can release an anticancer drug under the temperature-sensitive action of the wall material, polyvinylpyrrolidone and Arabic gum, and can then cooperate with the anticancer drug to efficiently and quickly kill cancer cells.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a preparation method of nanoparticle with slow-release controllable photothermal-magnetic-thermal-anticancer drug synergistic effect with magnetic targeting. Background technique [0002] As a major disease that threatens human life and health, cancer has long been characterized by low cure rate, high recurrence and high mortality. Since 2008, the global cancer rate has also been on the rise. In recent years, due to people's high life pressure, irregular work and rest diet, and more opportunities to be exposed to carcinogens, new cancer cases have also shown a certain trend of younger age. Surgery, radiotherapy, and chemotherapy are currently the main means and methods of cancer treatment. These methods all have great risks, and are likely to cause major trauma and complications to patients. At the same time, they are likely to cause greater damage to normal cells while killing cancer ...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K9/51A61K47/32A61K47/36A61K47/02A61K47/04A61K31/136A61P35/00
CPCA61K9/5115A61K9/5138A61K9/5161A61K9/5192A61K31/136A61K41/0052A61P35/00A61K2300/00
Inventor 王秉金小康陈碧玲万军民胡智文
Owner ZHEJIANG SCI-TECH UNIV
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