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Probiotic composition special for female and application thereof

A technology of composition and probiotics, applied in the direction of drug combination, non-active ingredients of polymer compounds, diseases, etc., can solve problems such as recurrent gynecological inflammation, decreased immunity, long-term cure, etc.

Inactive Publication Date: 2019-01-11
天津市聚星康华医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, with the acceleration of the pace of life in modern society and the increase of various pressures, due to irregular and unhealthy diet, abuse of antibiotics, poor personal hygiene habits and other reasons, many women are currently experiencing a decline in immunity, and gynecological inflammation recurs and persists for a long time. , seriously affecting normal work and life
[0006] Currently, the probiotic Lactobacillus for women that is common in the market is freeze-dried bacteria powder, which needs to be stored in refrigerated conditions, and its application is limited.

Method used

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  • Probiotic composition special for female and application thereof
  • Probiotic composition special for female and application thereof
  • Probiotic composition special for female and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Women's Special Probiotic Composition Capsules

[0018]

[0019] Preparation:

[0020] Prepare an appropriate amount of 15% starch slurry in advance.

[0021] Mix the prescription amount of Lactobacillus gratuitica, hydroxyethyl beta-cyclodextrin, malic acid and sodium alginate evenly, and set aside.

[0022] Dextrin is granulated with 15% starch slurry in a boiling granulator, and the granules are mixed with the above mixture, and then filled into capsules.

Embodiment 2

[0024] Women's Special Probiotic Composition Tablets

[0025]

[0026] Preparation:

[0027] Prepare an appropriate amount of ethanol solution (95%) containing 2% hydroxypropylmethylcellulose in advance.

[0028] Mix the prescribed amount of inert Lactobacillus and hydroxypropyl beta cyclodextrin evenly and set aside.

[0029] The prescription amount of lactic acid, hydroxypropyl methylcellulose, glucose and microcrystalline cellulose are uniformly mixed together, granulated with ethanol solution containing 2% hydroxypropylmethylcellulose, and dried at 50-60°C to obtain granules.

[0030] Mix the above inert lactobacillus mixture, granules and magnesium stearate evenly, and press into tablets to obtain.

Embodiment 3

[0032] Probiotic Composition Spray for Women

[0033]

[0034] Preparation:

[0035] Except for Lactobacillus jannis and silicon dioxide, other excipients are micronized. Weigh Lactobacillus jannis, hydroxymethylbeta-cyclodextrin, citric acid, chitosan, collagen and silicon dioxide according to the prescription amount, mix them evenly, and divide into packages to obtain the product.

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Abstract

The invention belongs to the field of healthy products, and relates to a probiotic composition special for female and application thereof. The probiotic composition special for female is characterizedby comprising 3%-20% of a female probiotic milk, 5%-50% of a stabilizer and 30%-80% of an adsorbent. In the probiotic composition special for female, other pharmaceutically acceptable auxiliary materials are selectively added, comprising a filler, an excipient, a lubricant, a gel, a binding agent, a flow aid, a disintegrating agent and a propellant. The probiotic composition special for female can be prepared into dosage forms such as powders, capsules, pills, tablets, sprays, ointments and gels and has effects of restoring vagina beneficial bacterium flora, reducing pH value in vagina and inhibiting growth of pathogenic bacteria. The preparation process of the probiotic composition special for female is simple and practicable, the used components are all common and moderate price. The probiotic composition special for female has good industrial prospect. The invention also provides the preparation process of the probiotic composition special for female.

Description

technical field [0001] The invention belongs to the field of health products, and relates to a special probiotic composition for women and its application. Background technique [0002] There are more than 200 kinds of microorganisms living in the vagina of healthy women, including aerobic bacteria and anaerobic bacteria, as well as mycoplasma and candida. The microbes in the vagina are dominated by Lactobacillus, accounting for 90% to 95% of the total microbial mass. Common Lactobacilli isolated from the vagina of healthy women include Lactobacillus fragilis, Lactobacillus jansneri, Lactobacillus gasseri, Lactobacillus fermentum, and Lactobacillus vaginalis. These flora in the vagina form a balanced ecological environment. When the body's immunity is low, the endocrine level changes or some external factors (such as tissue damage, sexual intercourse, etc.) destroy this micro-ecological balance, the harmful bacteria in these resident flora will break through the vaginal mu...

Claims

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Application Information

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IPC IPC(8): A61K35/747A61K47/40A61K47/12A61P15/02A61P31/02A61P31/10A61P33/02
CPCA61K35/747A61K9/0034A61K47/12A61K47/40A61P15/02A61P31/02A61P31/10A61P33/02A61K2300/00
Inventor 李化淋
Owner 天津市聚星康华医药科技有限公司