An in situ injectable thermosensitive response hydroxypropyl chitosan composite hydrogel for lacrimal embolism and its preparation method and application

A technology of hydroxypropyl chitosan and composite hydrogel, which is applied in application, pharmaceutical formulation, surgical adhesive and other directions, can solve the problems of increasing the patient's economic burden, high price, emboli displacement, etc., and achieves low cost, Low cost and less traumatic effect

Active Publication Date: 2021-08-03
陕西靓双瞳医疗科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the lacrimal duct embolization products used in the clinical treatment of dry eye disease in my country are all dependent on imports, which are expensive (1000-3000 yuan), and the cost of materials accounts for more than 80-90% of the operation cost, which greatly increases the economic burden of patients
In addition, the more important reason is that the imported lacrimal plug products designed based on European and American populations cannot fully adapt to the eye anatomical characteristics of Asian populations. In clinical applications, there are often problems of embolism shifting or falling off, resulting in surgical failure.

Method used

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  • An in situ injectable thermosensitive response hydroxypropyl chitosan composite hydrogel for lacrimal embolism and its preparation method and application
  • An in situ injectable thermosensitive response hydroxypropyl chitosan composite hydrogel for lacrimal embolism and its preparation method and application
  • An in situ injectable thermosensitive response hydroxypropyl chitosan composite hydrogel for lacrimal embolism and its preparation method and application

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Experimental program
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Embodiment 1

[0045] see figure 1 , is the experimental flow chart of the present invention. The method is as follows: 5% hydroxypropyl chitosan is dissolved in deionized water to prepare an aqueous solution of hydroxypropyl chitosan (HPCS), and 15% of β-glycerophosphate sodium (GP) is fully dissolved in deionized water. After stirring and dissolving, mix the above two aqueous solutions according to the volume ratio of 1:0.8 and stir evenly, then add 2% sodium alginate (Na-Alg) powder to the mixed solution, stir well to make it dissolve. Under the condition of stirring, in the mixed solution of embodiment 1, add 3% anhydrous calcium chloride (CaCl 2 ) aqueous solution, transfer the obtained mixed solution into a mold, and place it in a constant temperature water bath at 37°C to make it gel and transform into a hydrogel.

[0046] The mechanism of the gelation process is as figure 2 , image 3 and Figure 4 , figure 2 It is the gelation mechanism diagram of HPCS-GP. At room temperatur...

Embodiment 2

[0049] The mixed solution of embodiment 1 is moved in the vial, the result from Figure 5 It can be seen that the mixed solution has fluidity at room temperature; when it gels at 37°C, an in situ injectable thermosensitive response hydroxypropyl chitosan composite hydrogel for lacrimal embolism ( Figure 6 ), and from Figure 6 It can be seen that the mixed solution loses fluidity when the temperature is raised for a certain period of time.

Embodiment 3

[0051] The mass percent is respectively 1%, 3%, 5%, 7% and 9% hydroxypropyl chitosan dissolved in deionized water to prepare an aqueous solution of hydroxypropyl chitosan, 15% of β-sodium glycerophosphate in Fully stir in deionized water, after dissolving, mix the above two aqueous solutions according to the volume ratio of 1:0.8 and stir evenly, pour the obtained mixed solution into a mold, and wait for it to gel at 37°C to obtain lacrimal embolism In situ injectable temperature-sensitive response hydroxypropyl chitosan hydrogel, and observe its gelation time through the phenomenon in Example 1. The specific implementation method is: transfer a group of parallel samples with the same formula into vials , placed in a constant temperature water bath at 37°C, timed with a stopwatch, tilting or inverting one of the test tubes every 10s, and observing the flow behavior of the sol, if the sol no longer flows after one of the test tubes is inverted, record this time as gel The phase...

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Abstract

The invention discloses an in-situ injectable temperature-sensitive response hydroxypropyl chitosan composite hydrogel for lacrimal duct embolism, a preparation method and application thereof, and belongs to the technical field of medical products. The composite hydrogel of the present invention is a liquid sol at room temperature and has fluidity, and the sol can be placed into the lacrimal duct of the human eye by punctum injection. Utilizing the gel phase transition characteristic of the sol that is sensitive to body temperature, the in-situ gel embolization of the sol in the lacrimal duct is realized, and a small amount of tear fluid secreted by the affected eye is retained in the orbit, so as to achieve the purpose of keeping the ocular surface moist for a long time. Using the body temperature responsiveness of hydroxypropyl chitosan and sodium glycerophosphate complex, and adding alginate and calcium chloride to adjust its mechanical properties, sol-gel phase transition time, mechanical strength, etc., the operation is simple, The reaction conditions are mild, the cost is low, the biocompatibility is good, the trauma is small, and the lacrimal duct of any shape and size can be filled, and it has a good relief effect on patients with dry eye.

Description

technical field [0001] The invention belongs to the technical field of medical products, and relates to an in-situ injectable temperature-sensitive responsive hydroxypropyl chitosan composite hydrogel for lacrimal duct embolism, a preparation method and application thereof. Background technique [0002] Dry eye disease is an ocular disease caused by a variety of causes such as congenital lacrimal gland hypoplasia, trachoma, and corneal sclerosis, resulting in decreased tear film stability and abnormal tear quality or quantity. The etiology is more complex, related to the body's immunity, hormones and various growth factors, and generally requires long-term treatment. The essence of the disease is the reduction of the number and density of goblet cells in the tear film, which causes changes in the quality or quantity of tear secretion. The clinical symptoms are mainly dry eyes, itching, etc. The long-term accumulation of symptoms will cause deep lesions in the patient's corn...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/02A61L24/08A61L24/00
CPCA61L24/0031A61L24/02A61L24/08A61L2400/06C08L5/08C08L5/04
Inventor 薛伟明魏荣许宁侠温惠云黄赛朋杨华潘士印
Owner 陕西靓双瞳医疗科技发展有限公司
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