Preparation and application of graphene-ferrocene functionalized cyclodextrin chiral compound material

A composite material and graphene technology, which is applied in the preparation of β-cyclodextrin-based chiral composite materials and the preparation of cyclodextrin chiral composite materials, can solve problems such as low specific surface area and limitations

Inactive Publication Date: 2019-01-22
NORTHWEST NORMAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Graphene is a two-dimensional carbon nanomaterial with a honeycomb structure, which has been widely used in the field of electrochemical sensors. Compared with three-dimensional graphene, two-dimensional graphene has a lower specific surface area, so the application of two-dimensional graphene in restricted in a way

Method used

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  • Preparation and application of graphene-ferrocene functionalized cyclodextrin chiral compound material
  • Preparation and application of graphene-ferrocene functionalized cyclodextrin chiral compound material
  • Preparation and application of graphene-ferrocene functionalized cyclodextrin chiral compound material

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Embodiment 1

[0033] Embodiment 1, the preparation of chiral recognition material

[0034] (1) Preparation of graphene oxide (GO): Put expandable graphite into a crucible, place it in a muffle furnace, and heat it at 900-901°C for 30-50s to obtain expanded graphite. Put 1 g of expanded graphite into 500-501 mL of DMF, ultrasonicate for 24-25 h, wash and filter repeatedly with ethanol and water, and dry in vacuum at 60 °C to obtain exfoliated graphene. Put 1g of exfoliated graphite powder in a mixed solution of 90mL of concentrated sulfuric acid and 30mL of concentrated phosphoric acid, cool the temperature to about 0°C, then slowly add 10g of potassium permanganate, and control the reaction temperature below 5°C to prevent explosion. After the potassium permanganate was completely dissolved, the temperature was raised to 50°C and kept stirring at this temperature for 12h. After the reaction, the system was cooled to room temperature, and 200mL of ice water and 5mL of 30% hydrogen peroxide ...

Embodiment 2

[0037] Example 2. Construction of rGO-Fc-CD / GCE and chiral recognition of tryptophan isomers

[0038] Construction of chiral electrochemical sensor rGO-Fc-CD / GCE: uniformly disperse rGO-Fc-CD in water to form a new 1mg / mL dispersion, then take 8~9μL of 1mg / mL rGO-Fc-CD to disperse The droplets were coated on the surface of glassy carbon electrode (GCE) and dried to construct rGO-Fc-CD / GCE.

[0039] Chiral recognition of phenylalanine isomers: Immerse rGO-Fc-CD / GCE in 20mL 5mM / L of L-phenylalanine (L-Phe) and D-phenylalanine (D-Phe) isomers In vivo, differential pulse voltammetry was used for identification: the scanning potential was -0.2~0.6V, the pulse amplitude was 50mV, and the pulse width was 0.1s. Due to the interaction of L-phenylalanine and D-phenylalanine with rGO-Fc-CD / GCE, the peak current value of D-phenylalanine is larger, and the peak current value of L-phenylalanine is smaller, so that it can Recognition of phenylalanine isomers, recognition efficiency: I D ...

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Abstract

The invention discloses preparation and application of a graphene-ferrocene functionalized cyclodextrin chiral compound material. Firstly, graphene oxide (GO) is exfoliated by using ferrocene (Fc) through pi-pi action to reduce an aggregation effect of the GO and to increase interlayer spacing of the GO, so that functionalized GO-Fc is obtained; then under an alkaline condition, the GO-Fc and beta-cyclodextrin (beta-CD) are subjected to one-pot reaction to prepare the chiral compound material rGO-Fc-CD. A surface of a glassy carbon electrode (GCE) is modified with the chiral compound materialrGO-Fc-CD to form an electrochemical chiral sensing interface (rGO-Fc-CD / GCE), and the electrochemical chiral sensing interface (rGO-Fc-CD / GCE) has excellent conductivity. The chiral recognition material modified electrode rGO-Fc-CD / GCE is placed in a phenylalanine isomer solution, differential pulse voltammetry is used for scanning, and due to the fact that when L-phenylalanine and D-phenylalanine interact with the rGO-Fc-CD / GCE, peak current magnitude is different, a phenylalanine isomer can be identified fast and sensitively.

Description

technical field [0001] The present invention relates to the preparation of a β-cyclodextrin-based chiral composite material, in particular to the preparation of a graphene-ferrocene functionalized cyclodextrin chiral composite material; the present invention also relates to the chiral composite material The application in chiral recognition of phenylalanine enantiomers belongs to the technical field of composite materials and the field of electrochemical chiral recognition. Background technique [0002] Chirality is a ubiquitous phenomenon in living organisms, and the main metabolic process of living organisms is attached to stereochemistry. L-phenylalanine is a physiologically active aromatic amino acid, which is an essential amino acid for the basic biological components of the human body and most animals. The lack of L-phenylalanine will affect the synthesis of tyrosine in the body, resulting in a decrease in the level of thyroxine, thereby affecting its metabolic activi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L5/16C08K9/04C08K3/04C08B37/16G01N27/30G01N27/327
CPCC08B37/0012C08K9/04C08K3/042G01N27/308G01N27/3277C08L5/16
Inventor 莫尊理牛小慧杨星帅超刘振宇赵盼欧阳美璇郭瑞斌刘妮娟
Owner NORTHWEST NORMAL UNIVERSITY
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