Hydrogel, preparation method and applications thereof
A hydrogel and collagen technology, applied in medical science, prosthesis, etc., can solve the problems of reduced printability and application range, low colloid mechanical strength and toughness, slow curing speed, etc., to achieve adjustable biodegradation speed, The effect of adjustable mechanical strength and fast curing speed
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[0025] A kind of preparation method of hydrogel, it comprises: carrying out Michael addition reaction with maleic anhydride modified chitosan and thiolated collagen; The general formula of maleic anhydride modified chitosan is: The general formula of thiolated collagen is:
[0026] Among them, R 1 Remove the residues of amino groups for chitosan macromolecules; R 2 is a hydrogen atom, an alkyl group or an alkylene group; R 3 Is hydroxyl, hydroxyl derivatives, amino or amino derivatives; R 4 Removal of amino and carboxyl residues for collagen macromolecules; R 5 is an alkylene or substituted alkylene.
[0027] Chitosan, also known as chitosan, is the product of deacetylation of chitin and is a widely used natural polysaccharide. Chitosan is the only alkaline polysaccharide in nature. The free amino nitrogen atom on its molecular chain has a pair of unshared electron pairs, which can combine with a hydrogen proton, so that chitosan becomes a positively charged polyelec...
Embodiment 1
[0085] The preparation method of the hydrogel provided in this embodiment comprises:
[0086] (1) Accurately weigh 1.5 g of chitosan and dissolve it in acetic acid with a mass fraction of 0.01%. After being substantially uniformly dissolved under the action of a magnetic stirrer, place it in an ultrasonic oscillator for 30 minutes of sonication. Accurately weigh 1.8 g of maleic anhydride, add 5 ml of acetone to dissolve it completely. Add the dissolved maleic anhydride to the chitosan acetic acid solution at a constant speed, and stir for about 20 minutes under a magnetic stirrer to make it fully mixed. Transfer the uniformly mixed liquid into a 150ml round-bottomed flask, place it in a heat-collecting magnetic stirrer, set the temperature at 40°C, and heat at a constant temperature for 2 hours. Dialysis was performed for three days after the reaction stopped, and the dialysate was changed every 5 hours. Freeze-drying for three days yielded the MCS product.
[0087] Chemic...
Embodiment 2
[0094] The preparation method of the hydrogel provided in this embodiment comprises:
[0095] (1) Accurately weigh 1.5 g of chitosan and dissolve it in acetic acid with a mass fraction of 30%. After being substantially uniformly dissolved under the action of a magnetic stirrer, place it in an ultrasonic oscillator for 35 minutes of sonication. Accurately weigh 4.5 g of maleic anhydride, add 15 ml of acetone to dissolve it completely. Add the dissolved maleic anhydride to the chitosan acetic acid solution at a constant speed, and stir for 30 minutes under a magnetic stirrer to make it fully mixed. Transfer the uniformly mixed liquid into a 150ml round-bottomed flask, place it in a heat-collecting magnetic stirrer, set the temperature at 90°C, and heat it at a constant temperature for 10 hours. Dialysis was performed for two days after the reaction stopped, and the dialysate was changed every 4 hours. Freeze drying for two days yielded the MCS product.
[0096] Chemical reac...
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