Continuous production method of high-purity lactose

A production method and high-purity technology, applied in the field of continuous production of high-purity lactose, can solve the problems of lactose application limitations, adverse reactions, etc., and achieve the effect of simple and feasible production method, low cost and high yield

Pending Publication Date: 2019-02-01
广州市乐提食品科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the special source, the lactose produced by the traditional purification process, due to the presence of many impurities, can easily cause a series of adverse reactions such as urticaria, cough, fever, shock, etc. when administered by injection, which makes the original excellent performance The use of lactose in new drug delivery systems (especially injectable products) is extremely limited

Method used

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  • Continuous production method of high-purity lactose

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A kind of continuous production method of high-purity lactose provided by the present embodiment comprises the following steps:

[0025] (1) Mix crude lactose and purified water at a weight ratio of 1:8, stir and heat to 35°C to make a lactose solution, and then mix the lactose solution with the adsorbent (attapulgite-rice bran cellulose composite adsorption microspheres) according to 3.5 : the weight ratio of 100 is mixed, heated and boiled for 45min to obtain a mixed solution;

[0026] (2) Cool the mixture of crude lactose and adsorbent prepared in step (1) to 35°C and press filter to obtain a pure lactose solution, and then pass through the ultrafiltration device in sequence (the set pressure difference is 0.2MPa) , nanofiltration device (setting differential pressure is 0.7MPa) filtration, obtains the filter residue that intercepts;

[0027] (3) Mix the filter residue and purified water prepared in step (2) according to the weight ratio of 1:1.2, stir and heat to 8...

Embodiment 2

[0031] A kind of continuous production method of high-purity lactose provided by the present embodiment comprises the following steps:

[0032] (1) Mix crude lactose and purified water in a weight ratio of 1:5, stir and heat to 30°C to make a lactose solution, and then mix the lactose solution with the adsorbent (attapulgite-rice bran cellulose composite adsorption microspheres) according to 1 : the weight ratio of 100 is mixed, heated and boiled for 30min to obtain a mixed solution;

[0033] (2) Cool the mixture of crude lactose and adsorbent prepared in step (1) to 30°C and press filter to obtain a pure lactose solution, and then pass through the ultrafiltration device in sequence (the set pressure difference is 0.1MPa) , nanofiltration device (setting differential pressure is 0.6MPa) filtration, obtains the filter residue that intercepts;

[0034] (3) Mix the filter residue and purified water prepared in step (2) according to the weight ratio of 1:1, stir and heat to 80°C ...

Embodiment 3

[0038] A kind of continuous production method of high-purity lactose provided by the present embodiment comprises the following steps:

[0039] (1) After mixing crude lactose and purified water at a weight ratio of 1:10, stir and heat to 45°C to make a lactose solution, and then mix the lactose solution with the adsorbent (attapulgite-rice bran cellulose composite adsorption microspheres) according to 1 : mixed in a weight ratio of 100, heated and boiled for 30 to 60 minutes to obtain a mixed solution;

[0040] (2) Cool the mixture of crude lactose and adsorbent prepared in step (1) to 30°C and press filter to obtain a pure lactose solution, and then pass through the ultrafiltration device in sequence (the set pressure difference is 0.1MPa) , nanofiltration device (setting differential pressure is 0.6MPa) filtration, obtains the filter residue that intercepts;

[0041] (3) Mix the filter residue and purified water prepared in step (2) according to the weight ratio of 1:1.5, s...

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PUM

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Abstract

The invention discloses a continuous production method of high-purity lactose. The continuous production method comprises: (1) mixing a lactose crude product and purified water to prepare a lactose solution, and mixing an adsorbent and the lactose solution to obtain a mixed solution; (2) carrying out pressure filtration on the mixed solution to obtain a pure lactose solution, and sequentially filtering by an ultra-filtration device and a nano-filtration device to obtain a trapped filter residue; (3) mixing the obtained filter residue and purified water to prepare a lactose solution, mixing theobtained lactose solution and ethanol, and carrying out cooling crystallization to obtain a lactose solution with crystal precipitation; (4) carrying out centrifugal separation to obtain a lactose crystal; and (5) carrying out vacuum drying to obtain high-purity lactose. According to the present invention, by using adsorption, ultra-filtration, nano-filtration and alcohol water re-crystallization, the protein clearance rate is above 99.99%, and the removal rate of fructose, glucose and amino acid is over 99%; and the production method has characteristics of simpleness, feasibility, high lactose yield, low cost, environmental protection and safety, and is suitable for industrial production.

Description

technical field [0001] The invention relates to the technical field of lactose production technology, in particular to a continuous production method of high-purity lactose. Background technique [0002] Lactose is a reducing sugar with a molecular weight of about 300, which exists in milk, whey and other dairy products and dairy industry wastewater in the form of non-electrolyte. Lactose is one of the main nutrients for children's growth and development. It is very important for the intellectual development of adolescents, especially for newborn babies. It is often used in the manufacture of baby food, candy, and artificial milk. The lactose content in bovine milk is 4.6-4.7%, and the lactose content in human milk is 6-8%. Lactose is 1 / 5 as sweet as sucrose. In the food industry, lactose is used as baby food and condensed milk varieties. In the pharmaceutical industry, it is used as a flavoring agent, excipient, diluent, filler, dry powder inhalation carrier, stabilizer,...

Claims

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Application Information

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IPC IPC(8): C07H3/04C07H1/06C13K5/00
CPCC07H3/04C07H1/06C13K5/00
Inventor 黎惠仪
Owner 广州市乐提食品科技发展有限公司
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