A kind of preparation method of porous chitosan microspheres

A technology of porous chitosan and chitosan, which is applied in the field of preparation of porous chitosan microspheres, can solve the problems of limited adsorption effect, complex preparation process, poor particle dispersion, etc., and avoid long elution time and processing procedures Simple, low-cost effect
CN109293976BActive Publication Date: 2021-06-01WUHAN INSTITUTE OF TECHNOLOGY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
WUHAN INSTITUTE OF TECHNOLOGY
Publication Date
2021-06-01

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Abstract

The invention discloses a method for preparing porous chitosan microspheres. First, chitosan acetic acid solution and nanoparticle solution are added into an emulsified dispersant, and calcium ions are fully dispersed around chitosan molecules by mechanical stirring; then Adding a cross-linking agent and adjusting the pH value, calcium hydroxide particles are formed synchronously during the process of chitosan cross-linking into spheres, and in this process, calcium hydroxide generates nano-scale particles under the template effect of PEG. It is attached to the chitosan microsphere and occupies a certain position; after the cross-linking reaction, the microsphere product is soaked in hydrochloric acid to remove the calcium hydroxide particles, and then the porous chitosan microsphere is obtained. The chitosan microsphere synthesized by the invention has a large specific surface area and good dispersibility, which is beneficial to promote the adsorption modification performance of the chitosan microsphere, and the preparation method involved is simple, the reaction conditions are mild, and the requirements for equipment are low, and the subsequent treatment process Simple; low cost, suitable for popularization and application.
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Description

technical field

[0001] The invention belongs to the field of polymer materials and relates to a preparation method of porous chitosan microspheres. Background technique

[0002] The chemical name of chitosan (Chitosan) is poly(1,4)-2-amino-2-deoxy-β-D glucan, which is the product of de-N-acetylation of chitin and can be obtained in large quantities in nature. One of the natural polymers. There are active hydroxyl and amino groups in the chitosan macromolecule, which has the characteristics of strong chemical reaction ability, good biocompatibility, microbial degradation and non-toxic degradation products. Chitosan is one of the few charged natural products with many unique physical and chemical properties and biological functions. Chitosan microspheres have made major breakthroughs and are widely used in different fields such as drug carriers, food processing, water quality treatment, bioengineering and micro-separators. Chitosan microspheres with different particle sizes ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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