A kind of preparation method of porous chitosan microspheres

A technology of porous chitosan and chitosan, which is applied in the field of preparation of porous chitosan microspheres, can solve the problems of limited adsorption effect, complex preparation process, poor particle dispersion, etc., and avoid long elution time and processing procedures Simple, low-cost effect

Active Publication Date: 2021-06-01
WUHAN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the common preparation methods of chitosan microspheres include chemical cross-linking method, spray drying method, ion exchange method, complex coacervation method, electrostatic spray method and emulsification cross-linking method, etc.; , limited adsorption effect, etc.

Method used

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  • A kind of preparation method of porous chitosan microspheres
  • A kind of preparation method of porous chitosan microspheres
  • A kind of preparation method of porous chitosan microspheres

Examples

Experimental program
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Effect test

Embodiment 1

[0038] A preparation method of chitosan microspheres, comprising the following steps:

[0039] 1) Preparation of chitosan solution: chitosan (Mw 120000g·mol -1 ) was dissolved in acetic acid aqueous solution (2vol%), and the mass fraction of the preparation was 2% chitosan solution, sonicated at room temperature until completely dissolved, left standing to remove air bubbles, and a uniform and transparent chitosan solution was obtained;

[0040] 2) Preparation of emulsified dispersant: Mix 50 mL of liquid paraffin and 1 mL of Span-80, stir evenly to obtain emulsified dispersant;

[0041] 3) Preparation of nanoparticle solution: Dissolve 3g of anhydrous calcium chloride in 20ml of deionized water, then add 1.5g of PEG-600, and disperse evenly by ultrasonic to obtain a clear and transparent nanoparticle solution;

[0042] 4) Preparation of porous chitosan microspheres: at room temperature, add the emulsified dispersant obtained in step 2) into a 250ml round-bottomed flask and p...

Embodiment 2

[0046] A preparation method of chitosan microspheres, comprising the following steps:

[0047] 1) Preparation of chitosan solution: chitosan (Mw 150000g·mol -1 ) was dissolved in acetic acid aqueous solution (2vol%), and the mass fraction of the preparation was 2% chitosan solution, sonicated at room temperature until completely dissolved, left standing to remove air bubbles, and a uniform and transparent chitosan solution was obtained;

[0048] 2) Preparation of emulsified dispersant: mix 50 mL of liquid paraffin and 1.5 mL of Span-80, and stir evenly to obtain an emulsified dispersant;

[0049] 3) Preparation of nanoparticle solution: Dissolve 4g of anhydrous calcium chloride in 20ml of deionized water, then add 2g of PEG-600, and disperse evenly by ultrasonic to obtain a clear and transparent nanoparticle solution;

[0050] 4) Preparation of porous chitosan microspheres: at room temperature, add the emulsified dispersant obtained in step 2) into a 250ml round-bottomed flask ...

Embodiment 3

[0052] A preparation method of chitosan microspheres, comprising the following steps:

[0053] 1) Preparation of chitosan solution: chitosan (Mw 100000g·mol -1 ) was dissolved in acetic acid aqueous solution (2vol%), and the mass fraction of the preparation was 2% chitosan solution, sonicated at room temperature until completely dissolved, left standing to remove air bubbles, and a uniform and transparent chitosan solution was obtained;

[0054] 2) Preparation of emulsifying dispersant: mix 50 mL of liquid paraffin and 0.5 mL of Span-80, and stir evenly to obtain an emulsifying dispersant;

[0055] 3) Preparation of nanoparticle solution: Dissolve 2g of anhydrous calcium chloride in 20ml of deionized water, then add 1g of PEG-600, and disperse evenly by ultrasonic to obtain a clear and transparent nanoparticle solution;

[0056] 4) Preparation of porous chitosan microspheres: at room temperature, add the emulsified dispersant obtained in step 2) into a 250ml round-bottomed fl...

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Abstract

The invention discloses a method for preparing porous chitosan microspheres. First, chitosan acetic acid solution and nanoparticle solution are added into an emulsified dispersant, and calcium ions are fully dispersed around chitosan molecules by mechanical stirring; then Adding a cross-linking agent and adjusting the pH value, calcium hydroxide particles are formed synchronously during the process of chitosan cross-linking into spheres, and in this process, calcium hydroxide generates nano-scale particles under the template effect of PEG. It is attached to the chitosan microsphere and occupies a certain position; after the cross-linking reaction, the microsphere product is soaked in hydrochloric acid to remove the calcium hydroxide particles, and then the porous chitosan microsphere is obtained. The chitosan microsphere synthesized by the invention has a large specific surface area and good dispersibility, which is beneficial to promote the adsorption modification performance of the chitosan microsphere, and the preparation method involved is simple, the reaction conditions are mild, and the requirements for equipment are low, and the subsequent treatment process Simple; low cost, suitable for popularization and application.

Description

technical field [0001] The invention belongs to the field of polymer materials and relates to a preparation method of porous chitosan microspheres. Background technique [0002] The chemical name of chitosan (Chitosan) is poly(1,4)-2-amino-2-deoxy-β-D glucan, which is the product of de-N-acetylation of chitin and can be obtained in large quantities in nature. One of the natural polymers. There are active hydroxyl and amino groups in the chitosan macromolecule, which has the characteristics of strong chemical reaction ability, good biocompatibility, microbial degradation and non-toxic degradation products. Chitosan is one of the few charged natural products with many unique physical and chemical properties and biological functions. Chitosan microspheres have made major breakthroughs and are widely used in different fields such as drug carriers, food processing, water quality treatment, bioengineering and micro-separators. Chitosan microspheres with different particle sizes ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J9/26C08J3/24B01J13/14B01J20/26B01J20/28B01J20/30C08L5/08
CPCB01J13/14B01J20/046B01J20/24B01J20/267B01J20/28021C08J3/24C08J9/26C08J2201/0442C08J2305/08
Inventor 余军霞唐嘉齐池汝安陈佳东徐源来周芳
Owner WUHAN INSTITUTE OF TECHNOLOGY
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