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A kind of hemostatic needle, its preparation method and application

A needle and therapy technology, applied in the field of hemostatic needles, can solve the problems of lack of hemostatic methods and bleeding, and achieve the effects of strong design, good biocompatibility, and fast onset of action.

Active Publication Date: 2021-02-05
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is still a lack of effective hemostatic methods that can solve the bleeding problems caused by blood vessel and organ puncture

Method used

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  • A kind of hemostatic needle, its preparation method and application
  • A kind of hemostatic needle, its preparation method and application
  • A kind of hemostatic needle, its preparation method and application

Examples

Experimental program
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Effect test

preparation example Construction

[0033] The present invention proposes a method for preparing the hemostatic needle. The cross-linked polymer solution prepared by mixing the polymer matrix, the cross-linking agent and the solvent is coated on the peripheral surface of the needle, and the hemostatic coating with the hemostatic coating is obtained after removing the solvent. needle; wherein, the polymer matrix and the cross-linking agent are cross-linked through metal coordination, covalent bonds or non-covalent bonds to obtain the cross-linked polymer hemostatic coating, and non-covalent bond cross-linking such as Van der Waals forces, electrostatic interactions, and hydrogen bonds. In the preparation process of the hemostatic needle of the present invention, it is necessary to strictly control the concentration and ratio of the polymer matrix and the cross-linking agent, so that the two can be cross-linked with an appropriate degree of cross-linking, and then the polymer hemostatic coating will swell with wate...

Embodiment 1

[0045] A hemostatic needle is prepared according to the following method: first, according to the molar ratio of sodium alginate and calcium chloride of 1:1, a cross-linked polymer aqueous solution with a mass fraction of 5% is prepared, and then 40 μL of cross-linked polymer is coated on the syringe needle The solution was dried at room temperature to remove the solvent water to obtain a hemostatic needle with a cross-linked polymer coating thickness of 30 μm.

[0046] figure 1 Schematic diagram of the hemostatic needle prepared for this example, which includes a syringe needle, the peripheral surface of the needle is coated with a layer of hemostatic coating, the thickness of the hemostatic coating is 30 μm, the length of the hemostatic coating is 2 cm, and the hemostatic coating is close to the needle tip The distance from one end of the needle to the tip is 0, and the diameter of the needle is 710 μm.

[0047] figure 2 It is a schematic diagram of the preparation proces...

Embodiment 2

[0060] A kind of hemostatic needle is prepared according to the following method: first, according to chitosan and sodium glycerophosphate molar ratio 1:3 configuration mass fraction is the cross-linked polymer aqueous solution of 15%, and then the cross-linked polymer of 80 μ L is coated on syringe needle solution, drying to remove the solvent water to obtain a hemostatic needle with a cross-linked polymer coating thickness of 178 μm, the length of the hemostatic coating is 5.5 cm, and the distance between the end of the hemostatic coating and the needle tip is 2 cm, and the The diameter is 1.26 mm.

[0061] Effect verification:

[0062] 1 Simulated hemostatic effect in vitro

[0063] The hemostatic needle was prepared by using the method in Example 2, and the hemostatic effect was simulated in vitro by puncturing the skin of nude mice. Take the skin of the nude mouse and fix it to the lower end of the syringe, add a certain volume of normal saline to the syringe, use a bla...

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Abstract

The invention belongs to the field of biomedical polymer materials, and particularly relates to a hemostasis needle and a preparing method and application thereof. The hemostasis needle comprises a syringe needle and a hemostasis coating for coating the surface of the periphery of the syringe needle, wherein the hemostasis coating is a non-toxic cross-linked polymer which can swell and shed off from the surface of the periphery of the syringe needle when meeting a solvent. The hemostasis needle prepared by means of the method is utilized for puncturing the blood vessels and the visceral organs, after the hemostasis needle is pulled out, the coating is left at the puncturing position to block a puncturing hole, and thus synchronous hemostasis is achieved. The preparing method of the hemostasis needle is easy to operate and low in cost, takes effect quickly, and can be widely applied to the fields such as drug administration, blood sampling, sampling and interventional therapy on patients with normal or abnormal clinical blood coagulation functions. The hemostasis needle is adjustable in size, easy to produce on a large scale, capable of effectively solving the problem that unnecessary hemorrhage is caused when the patients with normal or abnormal clinical blood coagulation functions are subjected to blood vessel and visceral organ puncturing, and free of obvious untoward effects.

Description

technical field [0001] The invention belongs to the field of biomedical polymer materials, and more specifically relates to a hemostatic needle, its preparation method and application. Background technique [0002] Clinically, venipuncture blood collection or fluid therapy, organ puncture and biopsy are common detection and diagnosis methods. Often, venipuncture or visceral puncture causes unavoidable bleeding. Although most bleeding will not cause pathophysiological changes in patients, it will cause psychological panic and fear in patients. In addition, for patients with coagulation disorders, such as hemophilia and patients on anticoagulant therapy, the puncture process may cause severe bleeding. [0003] At present, after puncture of blood vessels and organs, patients can use bandages, pressure bandages, finger pressure, tourniquets, etc. to stop bleeding. Among them, finger pressure hemostasis is commonly used in blood vessel puncture, which requires the help of exte...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/00A61B17/12A61B17/34
CPCA61B17/12A61B17/12181A61B17/34A61B2017/12004
Inventor 张连斌任敬丽朱锦涛尹兴杰张春苏华
Owner HUAZHONG UNIV OF SCI & TECH
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