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Heparinoid gel microsphere and preparation method thereof and purpose thereof

A gel microsphere, heparin-like technology, applied in the directions of gel preparation, chemical instruments and methods, colloid chemistry, etc., can solve the problems of hypocalcemia, complicated operation, systemic coagulation effects, etc., to improve dimensional stability, Conducive to industrialization and rich in resources

Active Publication Date: 2019-02-15
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although high-flow hemodialysis without anticoagulation greatly reduces the risk of bleeding, the treatment time and adequacy cannot be guaranteed, and blood coagulation in the tube may also cause blood loss in patients; local citrate anticoagulation can ensure anticoagulation during extracorporeal circulation less effect on systemic blood coagulation
However, the citrate-Ca2+ complex will still enter the human body, as a by-product of heparin-free treatment, it needs to be metabolized by the liver, which may lead to citrate poisoning and hypocalcemia in patients with abnormal liver function
In addition, the RCA method is complicated to operate and needs to monitor blood gas and blood calcium at the same time, which also limits its application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] 8 parts of polyethersulfone and 92 parts of N,N-dimethylacetamide were completely dissolved under stirring at 60 degrees Celsius to obtain a polyethersulfone solution. Quantitatively weigh 18 parts of acrylic acid, 12 parts of 2-acrylamide-2-methylpropanesulfonic acid, 1 part of N,N'-methylenebisacrylamide, 0.5 parts of ammonium persulfate, 0.5 parts of sodium lauryl sulfate Dissolve in 68 parts of deionized water, and ultrasonically dissolve at room temperature for 1 hour to obtain a coagulation bath of the reaction liquid. The prepared polyethersulfone solution was put into a standard 10 ml syringe, the needle was connected to a voltage of 7000 volts, the height of the needle was 10 cm from the coagulation bath of the heparinoid reaction solution, and the injection speed was 1.5 mm per minute. Under this condition, the polyethersulfone solution is dropped into the coagulation bath of the heparinoid reaction solution to obtain polyethersulfone microspheres with the hep...

Embodiment 2

[0054] 16 parts of polyethersulfone and 84 parts of N,N-dimethylacetamide were completely dissolved under stirring at 60 degrees Celsius to obtain a polyethersulfone solution. Quantitatively weigh 18 parts of acrylic acid, 12 parts of 2-acrylamide-2-methylpropanesulfonic acid, 1 part of N,N'-methylenebisacrylamide, 0.5 parts of ammonium persulfate, 0.5 parts of sodium lauryl sulfate Dissolve in 68 parts of deionized water, and ultrasonically dissolve at room temperature for 1 hour to obtain a coagulation bath of the reaction liquid. The prepared polyethersulfone solution was put into a standard 10 ml syringe, the needle was connected to a voltage of 7000 volts, the height of the needle was 10 cm from the coagulation bath of the heparinoid reaction solution, and the injection speed was 1.5 mm per minute. Under this condition, the polyethersulfone solution is dropped into the coagulation bath of the heparinoid reaction solution to obtain polyethersulfone microspheres with the he...

Embodiment 3

[0058] 8 parts of polyethersulfone and 92 parts of N,N-dimethylacetamide were completely dissolved under stirring at 60 degrees Celsius to obtain a polyethersulfone solution. Quantitatively weigh 18 parts of acrylic acid, 12 parts of 2-acrylamide-2-methylpropanesulfonic acid, 1 part of N,N'-methylenebisacrylamide, 0.5 parts of ammonium persulfate, 0.5 parts of sodium lauryl sulfate Dissolve in 68 parts of deionized water, and ultrasonically dissolve at room temperature for 1 hour to obtain a coagulation bath of the reaction liquid. The prepared polyethersulfone solution was put into a standard 10 ml syringe, the needle was connected to a voltage of 10,000 volts, the height of the needle was 10 cm from the coagulation bath of the heparinoid reaction solution, and the injection speed was 1.5 mm per minute. Under this condition, the polyethersulfone solution is dropped into the coagulation bath of the heparinoid reaction solution to obtain polyethersulfone microspheres with the h...

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Abstract

The invention discloses a heparinoid gel microsphere. The heparinoid gel microsphere is prepared through coagulating bath reaction between a polymer solution and a heparinoid reaction fluid; and the heparinoid gel microsphere has a functional group similar to anticoagulant heparin. The heparinoid gel microsphere disclosed by the invention has the advantages that the anticoagulation property is excellent, the dimension is stable, and breakage cannot be caused by a reason of swelling or a pressure in the blood treatment process. The invention further provides a preparation method of the heparinoid gel microsphere; and the preparation method of the heparinoid gel microsphere is simple and suitable for industrialization. The invention further discloses a purpose of the heparinoid gel microsphere and can be used for the field of blood purification.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to a heparin-like gel microsphere and a preparation method and application thereof. Background technique [0002] At present, the global prevalence of chronic kidney disease has exceeded 10%, and many of these patients will develop kidney failure and uremia. Due to the high cost of treatment and the lack of transplantable organs, the treatment of kidney transplantation is difficult to be effectively promoted. Therefore, blood purification therapy, as a renal replacement therapy, is the main treatment for patients with kidney disease. For a long time, anticoagulation and blood purification go hand in hand. During blood purification, extracorporeal blood circulation pathways often require some form of anticoagulation to reduce thrombus formation. The thrombus formed during blood purification may fall off and enter the body with the blood flow, causing more serious ...

Claims

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Application Information

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IPC IPC(8): B01J13/00C08F283/00C08F220/06C08F220/58C08F222/38
CPCB01J13/0065C08F283/00C08F220/585
Inventor 赵伟锋纪海锋赵长生宋昕李育沛苏白海张小华张珏
Owner SICHUAN UNIV
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