Composition for eliminating skin stains as well as preparation method and application thereof

A composition and a technology for pigmentation, which are applied in the field of compositions for removing pigmentation on the skin, can solve the problems of excessive loss of skin moisture, damage to the stratum corneum of the skin, easy aging, etc. easy effect

Inactive Publication Date: 2019-03-01
周君梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the use of fruit acid for skin rejuvenation and freckle removal requires extremely high requirements. First, strict aseptic control is required; secondly, due to the use of high-concentration ...

Method used

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  • Composition for eliminating skin stains as well as preparation method and application thereof
  • Composition for eliminating skin stains as well as preparation method and application thereof
  • Composition for eliminating skin stains as well as preparation method and application thereof

Examples

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Effect test

preparation example Construction

[0038] A preparation method for a composition for removing skin pigmentation, comprising the following steps:

[0039] (1) Dried Chuanqiong, rose, lemon and white peony root in the sun, powdered them, added water at a solid-to-liquid ratio of 1:20, soaked for 10 hours, heated and refluxed to extract for 3-5 hours, filtered, and retained the filtrate; added water of equal quality to the filter residue , after heating to reflux for 2 hours, filter, discard the filter residue, combine the two filtrates, and concentrate to obtain a concentrated solution A with a specific gravity between 1.0-1.5;

[0040] (2) Add 6′-acetylated arbutin and vitamin E to the mixer, add deionized water, stir at 200r / min for 15min, continue to add egg white and pearl powder, stir at the same speed and disperse evenly, then add concentrated solution A, emulsify agent and antioxidant, heated to 60° C. and stirred for 2 hours, then cooled to room temperature, filled, sealed and stored to obtain a compositi...

Embodiment 16

[0042] Example 1 Preparation of 6′-acetylated arbutin

[0043] Raw material composition: arbutin, tetrahydrofuran, CSL lipase, vinyl acetate, all analytically pure, purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.;

[0044] Follow the steps below:

[0045] Add 0.73mmol arbutin, 30mmol vinyl acetate, and 100mg CSL lipase into a reactor filled with 20mL tetrahydrofuran, heat to 60°C with 400W microwave, and stir at 100r / min to react. The water activity of the reaction is 0.41, and the reaction time is 2.5 h, terminate the reaction, filter the enzyme with a 0.22 μm microporous membrane filter, and evaporate the solvent to dryness to get final product, the yield is 92.5%, and the HPLC figure of reaction monitoring is as attached figure 1 and 2 shown.

[0046] figure 1 For the HPLC chart of the substrate when the arbutin non-aqueous phase acetylation reaction is 0h, the retention time of the arbutin substrate is approximately 6.869min, and the peak area is about...

Embodiment 2

[0058] Example 2 Preparation of 6'-acetylated arbutin

[0059] Raw material composition: arbutin, thionyl chloride, Novozym 435 lipase, vinyl propionate, all analytically pure, purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.;

[0060] Follow the steps below:

[0061] Add 0.73mmol arbutin, 30mmol vinyl propionate, and 100mg Novozym 435 lipase into a reactor containing 20mL thionyl chloride, heat to 60°C with 400W microwave, and stir at 100r / min to react. The water activity of the reaction is 0.41, the reaction time was 2.5 hours, the reaction was terminated, the enzyme was filtered through a 0.22 μm microporous membrane, and the solvent was spun to dryness, and the yield was 83.1%.

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Abstract

The invention discloses a composition for eliminating skin stains. The composition is prepared from the following raw materials in parts by weight: 30-50 parts of 6'-acetylated arbutin, 20-30 parts oflemon, 20-25 parts of rose, 10-20 parts of egg white, 10-30 parts of rhizoma chuanxiong, 15-30 parts of radix paeoniae alba, 20-40 parts of pearl powder, 10-20 parts of vitamin E, 1-5 parts of an emulsifier, 1-5 parts of an antioxidant and 200-300 parts of deionized water. According to the composition disclosed by the invention, the acetylated arbutin not only has a good effect of inhibiting thesynthesis of melanin, but also can avoid the activity loss of the arbutin caused by oxidation. Therefore, the oxidation resistance of the acetyl modified arbutin is obviously enhanced, the shelf lifeis longer, and the stability is better in the physiological environment of cells.

Description

technical field [0001] The invention relates to the technical field of light chemical industry, in particular to a composition for removing skin spots. Background technique [0002] Skin color is primarily determined by the amount and type of melanin, a brown pigment present in the skin. The less the amount of melanin, the whiter the skin, and the more the melanin, the darker the skin. In addition, hyperpigmentation of the skin is also caused by the overexpression or accumulation of melanin in the skin. Therefore, the pathways involved in melanin production have been the target of many inhibitors used to reduce the level of melanin production. One of the main enzymes involved in the melanin pathway is tyrosinase. Melanin synthesis is a hormone-controlled process involving melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH) peptides produced from the precursor proopiomelanocortin. DNA damage caused by UVB irradiation can stimulate this process. Ac...

Claims

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Application Information

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IPC IPC(8): A61K8/98A61K8/9789A61K8/67A61K8/60A61Q19/00A61Q19/02
CPCA61K8/602A61K8/678A61K8/982A61K8/987A61K2800/782A61K2800/81A61Q19/00A61Q19/02A61K8/9789
Inventor 周君梅
Owner 周君梅
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