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Traditional Chinese medicine composition, external use latex, preparation method and application thereof

A composition and technology of traditional Chinese medicine, applied in the field of medicine, can solve the problems of poor promotion effect, unsatisfactory swelling elimination effect and the like, and achieve the effect of good therapeutic effect

Inactive Publication Date: 2019-03-08
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many chemical drugs for the treatment of burns and scalds, such as antibacterial chemical drugs, silver salts, etc. The main functions are antibacterial, anti-inflammatory, and analgesic, but there are some adverse reactions in common chemical drugs, and the effect of promoting skin tissue regeneration on burns and scalds Relatively poor, unsatisfactory effect on swelling after burn and scald; according to clinical feedback, traditional Chinese medicine has obvious advantages in eliminating swelling and promoting wound healing. Commonly used clinical Chinese medicine preparations include burn analgesic ointment, MEBO moist burn Ointment, Kangfuxin liquid, Comfrey burn and scald spray, etc.

Method used

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  • Traditional Chinese medicine composition, external use latex, preparation method and application thereof
  • Traditional Chinese medicine composition, external use latex, preparation method and application thereof
  • Traditional Chinese medicine composition, external use latex, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Embodiment one: the preparation of American cockroach extract

[0088] Take the dried worm body of Periplaneta americana, put it in a hot reflux extraction tank, add 80% ethanol at a ratio of 1:7 to reflux and extract at 70°C for 3 times, and combine the extracts; filter the extracts with a plate and frame After machine filtration, the filtrate is concentrated into an extract with a relative density of 1.1 by a single-effect evaporator, and distilled water with 5 to 10 times the mass of the extract is added to the extract. Carry out oil-water separation; take the centrifuged water phase and concentrate it into an extract with a relative density of 1.2 to 1.3 through a single-effect evaporator to obtain the extract of Periplaneta americana. The detected free amino acid content is 16.68%, and the total peptide content is 25.59%.

Embodiment 2

[0089] Embodiment two: the preparation of comfrey oil

[0090] Clean the comfrey, cut it into small pieces, add olive oil at the ratio of material to liquid 1:10, soak at room temperature for 24 hours, then heat in a water bath at 80°C for two hours, filter, remove the filter residue, and obtain the crude comfrey extract . Filter the crude comfrey extract through a 0.45 μm filter membrane, add borneol according to the mass ratio of borneol: filtrate 1:100, and stir evenly to obtain comfrey oil.

Embodiment 3

[0092] Weigh 0.8g of Carbomer 940, add 70ml of water, let it stand overnight to make it fully swell, add 3g of glycerol after swelling, stir evenly, and form a latex matrix. Mix 3g of comfrey oil and 1.5g of Tween 80 into a mortar, add 0.05g of methylparaben and 0.05g of propylparaben, after fully mixing and dissolving, add 4g of distilled water and stir in the same direction Colostrum is formed. Add 4g of distilled water to the colostrum and stir evenly, dilute the colostrum into an emulsion, and add the emulsion to the latex matrix. Dilute 0.75g Periplaneta americana extract with a small amount of water, add it to the latex matrix, stir evenly, add distilled water to make the matrix quality reach 100g. Add a small amount of triethanolamine to adjust the pH value of the latex, so that the pH value reaches between 6 and 7. The prepared latex has a viscosity of 16500mPa·s, good adhesion and ductility, and good centrifugal stability.

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Abstract

The invention belongs to the technical field of medicine, and discloses a composition prepared from American cockroaches extracts and lithospermum extracts, external use latex containing the composition and a preparation method thereof. The treatment effect of the latex on burn and scald treatment is compared and explained. The mass ratio of American cockroaches extracts to lithospermum extracts is 1:(1 to 15); the addition proportion of American cockroaches extracts, lithospermum oil and gel substrates in the latex is (1 to 3):(3 to 15):(100 to 120). The emulsifiers are used for emulsifying lithospermum oil and water into O / W type latex drips; the latex drips can stably exist in a gel substrate for a long time; the defect that the lithospermum oil is insoluble in hydrogel is overcome. Compared with single use of kangfuxin solution and lithospermum extracts, the combined medicine can generate the synergistic interaction effects; the treatment effect is more obvious; the clinic use is safe and reliable.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to a traditional Chinese medicine composition, its external latex and its preparation method and application, in particular to a traditional Chinese medicine composition for treating burns and a preparation method of its external latex. Background technique [0002] Burns refer to human skin or mucous membrane damage caused by heat sources or chemical substances. In severe cases, the subcutaneous tissue may be damaged. It is a common and difficult-to-treat traumatic disease in our lives. If the burn is not treated properly in time, it may cause very serious sequelae. Statistics show that about 20 million people suffer from burns of varying degrees in my country every year, which exceeds 1% of the total population of my country, and the number of hospitalized people accounts for about 5.0% of the total number of burns and scalds. At present, there are many chemical drugs for the trea...

Claims

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Application Information

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IPC IPC(8): A61K36/30A61K9/06A61K47/26A61K47/32A61P17/02A61P31/02A61K35/64A61K31/045
CPCA61K9/0014A61K9/06A61K31/045A61K35/64A61K36/30A61K47/26A61K47/32A61K2236/35A61P17/02A61P31/02A61K2300/00
Inventor 韩静王爽韩阳
Owner SHENYANG PHARMA UNIVERSITY
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