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Preparation method of drug-loaded zinc oxide and silicon dioxide composite nanoparticles

A technology of zinc oxide nano and silicon dioxide, which is applied in the field of medicine, can solve the problems of not reaching the target effect, achieve the effect of delaying the release, slowing down the release of drugs, and overcoming the effect of easy shedding and precipitation

Inactive Publication Date: 2019-03-26
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the release is too fast, the drug will be completely released before reaching the target organ tissue, and the targeted effect will not be achieved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Take 10g of zinc chloride in a 500mL beaker, add a small amount of distilled water to dissolve, add 300mL of glycerol, titrate to pH = 11 with 2mol / L sodium hydroxide solution, and heat at 130°C for 30min. Zinc oxide nanoparticle precipitate was obtained after centrifugation. Weigh 2g of the above-mentioned zinc oxide nanoparticles into a three-necked bottle, dissolve 2g of curcumin in 20mL of dimethyl sulfoxide, and then add it into the three-necked bottle. Magnetically stirred at 90° C. for 2 hours, centrifuged, washed with 95% ethanol and then centrifuged, and the supernatant was discarded to obtain a precipitate of curcumin zinc oxide nanoparticles. Ultrasonic disperse the precipitate in 20mL 50% ethanol water mixed solution, add 1g tetraethyl orthosilicate, adjust the solution to pH = 11 with ammonia water, react at room temperature for 1h, wash twice with 50% ethanol aqueous solution after centrifugation , get sediment. The precipitate is drug-loaded zinc oxide ...

Embodiment 2

[0035] Take 10g of zinc chloride in a 500mL beaker, add a small amount of distilled water to dissolve, add 300mL of glycerol, titrate to pH=10 with 2mol / L sodium hydroxide solution, and heat at 120°C for 30min. Zinc oxide nanoparticle precipitate was obtained after centrifugation. Weigh 2 g of the above-mentioned zinc oxide nanoparticles into a three-neck flask, dissolve 2 g of hydroxycamptothecin in 20 mL of dimethyl sulfoxide, and then add it into the three-neck flask. 60°C magnetic stirring for 1 hour, centrifugation, washing with 95% ethanol and centrifugation again, discarding the supernatant to obtain hydroxycamptothecin zinc oxide nanoparticle precipitate. Ultrasonic disperse the precipitate in 20mL 50% ethanol water mixed solution, add 0.8g tetraethyl orthosilicate, adjust the solution to pH=11 with ammonia water, react at room temperature for 1h, wash with 50% ethanol water solution for 2 hours after centrifugation Second, get sediment. The precipitate is drug-loade...

Embodiment 3

[0037] Take 15g of zinc chloride in a 500mL beaker, add a small amount of distilled water to dissolve, add 300mL of glycerol, titrate to pH = 11 with 2mol / L sodium hydroxide solution, and heat at 120°C for 40min. Zinc oxide nanoparticle precipitate was obtained after centrifugation. Weigh 1 g of the above-mentioned zinc oxide nanoparticles into a three-necked flask, dissolve 1 g of paclitaxel in 20 mL of dimethyl sulfoxide, and then add it into the three-necked flask. React with magnetic stirring at 60° C. for 1 h, centrifuge, wash with 95% ethanol and centrifuge again, discard the supernatant, and obtain paclitaxel zinc oxide nanoparticle precipitate. Ultrasonic disperse the precipitate in 10 mL of 50% ethanol water mixed solution, add 0.6 g tetraethyl orthosilicate, adjust the solution to pH = 11 with ammonia water, react at room temperature for 1 h, wash with 50% ethanol water solution for 2 h after centrifugation Second, get sediment. The precipitate is drug-loaded zinc ...

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Abstract

The invention belongs to the technical field of medicine and relates to a preparation method of drug-loaded zinc oxide and silicon dioxide composite nanoparticles. According to the preparation method,zinc oxide nanoparticles serve as a core, then the surface of the core is encapsulated in a drug through physical adsorption, a hydrogen bond or a coordination bond, and in order to prevent the drugfrom falling off or precipitating from the surface of zinc oxide and improve the stability of the drug, the surface of the drug is coated with a layer of silicon dioxide, and thus the drug-loaded zincoxide and silicon dioxide composite nanoparticles are prepared. Through the preparation method, entrapment of compounds such as hydroxycamptothecin, camptothecin, taxol, curcumin, azithromycin and acyclovir can be achieved, wherein the compounds can form the hydrogen bond with the zinc oxide. The maximum entrapment amount can reach 50% of a carrier. The surfaces of the drug-loaded zinc oxide nanoparticles are further encapsulated in the silicon dioxide to encapsulate the drug in the silicon dioxide, thus the drug encapsulation rate can be well increased, and drug releasing of delayed.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a preparation method of drug-loaded zinc oxide silicon dioxide composite nanoparticles. Background technique [0002] Due to its small particle size, large specific surface area, and obvious surface and interface effects, nano-zinc oxide exhibits unique physical and chemical properties in the fields of chemistry, optics, biology, and electricity. In recent years, drug carriers based on nano-zinc oxide have been studied by many people. It has developed from simple drug delivery to the stage of intelligent drug controlled release. The intelligent drug carrier based on nano-zinc oxide can respond to the corresponding external stimulus to control the drug release behavior. The development of smart drug carriers that can control drug release behavior through external stimuli has attracted much attention. However, when zinc oxide is used as a drug carrier, the drug is loaded on the su...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/02A61K47/04A61K47/52A61K31/12A61K31/4745A61K31/337A61P35/00
CPCA61K9/5115A61K31/12A61K31/337A61K31/4745A61K47/52A61P35/00
Inventor 孙文靓孙言杨星钢
Owner SHENYANG PHARMA UNIVERSITY
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