Preparation method of drug-loaded zinc oxide and silicon dioxide composite nanoparticles
A technology of zinc oxide nano and silicon dioxide, which is applied in the field of medicine, can solve the problems of not reaching the target effect, achieve the effect of delaying the release, slowing down the release of drugs, and overcoming the effect of easy shedding and precipitation
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[0032] Example 1
[0033] Take 10g of zinc chloride in a 500mL beaker, add a small amount of distilled water to dissolve, then add 300mL of glycerol, titrate with 2mol / L sodium hydroxide solution to pH=11, and heat at 130°C for 30min. After centrifugation, a zinc oxide nanoparticle precipitate is obtained. Weigh 2 g of the above-mentioned zinc oxide nanoparticles into a three-necked flask, dissolve 2g of curcumin in 20 mL of dimethyl sulfoxide, and then add it to the three-necked flask. The reaction was magnetically stirred at 90°C for 2 hours, centrifuged, washed with 95% ethanol and then centrifuged, and the supernatant was discarded to obtain the curcumin zinc oxide nanoparticle precipitate. The precipitate was ultrasonically dispersed in 20 mL of 50% ethanol-water mixed solution, 1g of ethyl orthosilicate was added, the solution was adjusted to pH=11 with ammonia water, and the reaction was carried out at room temperature for 1 hour. After centrifugation, it was washed twice...
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[0034] Example 2
[0035] Take 10g of zinc chloride in a 500mL beaker, add a small amount of distilled water to dissolve, then add 300mL of glycerol, titrate with 2mol / L sodium hydroxide solution to pH=10, and heat at 120°C for 30min. After centrifugation, a zinc oxide nanoparticle precipitate is obtained. Weigh 2 g of the above-mentioned zinc oxide nanoparticles into a three-necked flask, dissolve 2g of hydroxycamptothecin in 20 mL of dimethyl sulfoxide and add it to the three-necked flask. The reaction was magnetically stirred at 60°C for 1 hour, centrifuged, washed with 95% ethanol and then centrifuged, and the supernatant was discarded to obtain the hydroxycamptothecin zinc oxide nanoparticle precipitate. The precipitate was ultrasonically dispersed in 20 mL of a 50% ethanol-water mixed solution, 0.8 g of ethyl orthosilicate was added, the solution was adjusted to pH = 11 with ammonia water, and the reaction was carried out at room temperature for 1 hour. After centrifugatio...
Example Embodiment
[0036] Example 3
[0037] Take 15g of zinc chloride in a 500mL beaker, add a small amount of distilled water to dissolve, then add 300mL of glycerol, titrate with 2mol / L sodium hydroxide solution to pH=11, and heat at 120°C for 40min. After centrifugation, a zinc oxide nanoparticle precipitate is obtained. Weigh 1g of the above-mentioned zinc oxide nanoparticles into a three-necked flask, dissolve 1g of paclitaxel in 20mL of dimethyl sulfoxide, and then add it to the three-necked flask. The reaction was magnetically stirred at 60°C for 1 hour, centrifuged, washed with 95% ethanol and then centrifuged, and the supernatant was discarded to obtain paclitaxel zinc oxide nanoparticles precipitate. The precipitate was ultrasonically dispersed in 10 mL of a 50% ethanol-water mixed solution, 0.6 g of ethyl orthosilicate was added, the solution was adjusted to pH = 11 with ammonia water, and the reaction was carried out at room temperature for 1 hour. After centrifugation, it was washed ...
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