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Pit-hole composite micro-nano structure polysaccharide microspheres and preparation method thereof

A technology of micro-nano structure and polysaccharides, which is applied in the preparation of microspheres, microcapsule preparations, pharmaceutical formulations, etc., can solve the problems of large particle size distribution, single structure, and difficult to control microscopic morphology, and achieve high porosity, The effect of uniform particle size distribution and good physical and chemical properties

Active Publication Date: 2021-04-02
WENZHOU INST OF BIOMATERIALS & ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In short, the microspheres prepared by the above methods have the problems of single structure, difficult control of microscopic morphology, and excessive particle size distribution.

Method used

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  • Pit-hole composite micro-nano structure polysaccharide microspheres and preparation method thereof
  • Pit-hole composite micro-nano structure polysaccharide microspheres and preparation method thereof
  • Pit-hole composite micro-nano structure polysaccharide microspheres and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044]The preparation method of the pit-hole composite microena structure, including the following steps:

[0045](1) The proportion of mass ratio is 1: 2: 2, the degree of substitution: ≥ 80%, the carboxymethylge glycans having a viscosity of 10 MPa.s, the weight average molecular weight of 100,000 hyal sodium sodium and viscosity is 100 MPa.s Sodium alginate is dissolved in ultrapure water, and the aqueous solution of mass concentration is 2%;

[0046](2) Mix the mass ratio of 1: 1, and Tween 85 and Tween-80 mixed emulsifier, add liquid paraffin, so that the mass fraction of the emulsifier is 0.4%, 40 ° C, stirred, dissolved, to contain emulsifiers The oil phase; the polysaccharide solution is added dropwise to the emulsifier in the oil phase, and the mixture is stirred, the stirring time is 4 h, resulting in a uniform emulsion; the emulsifier-containing oil phase and the mass ratio of the polyglycan solution 10: 1;

[0047](3) Put CaCl2Soluble in ultrapure water, a crosslinking agent havi...

Embodiment 2

[0053]The preparation method of the pit-hole composite microena structure, including the following steps:

[0054](1) The viscosity of 1: 1: 1 is 4500 MPa.s sketchloride, the weight average molecular weight of 100,000 carboxymethyl glucosaccharides, and the weight average molecular weight is 50,000 hyal sodium sodium. In the water, a polyglycan solution having a mass concentration is 10%;

[0055](2) Add the emulsifier plate 80 to soybean oil, so that the mass fraction of the emulsifier is 5%, stirred at 80 ° C, stirred, and the oil phase containing the emulsifier; then a polyglycan solution is added dropwise. In the oil phase containing the emulsifier, 800 rpm was stirred and emulsified, and the stirring time was 1 h, resulting in a homogeneous emulsion; the molecule of the emulsifier and the mass ratio of the polyglycan solution was 3: 1;

[0056](3) Put ZnCl2The dissolved water is dissolved in a crosslinking agent having a mass concentration of 30%, and a mixed agent aqueous solution is a...

Embodiment 3

[0062]The preparation method of the pit-hole composite microena structure, including the following steps:

[0063](1) Carboxymelogolmetan having a mass ratio of 2: 1: 1 having a weight average molecular weight of 80,000, the weight average molecular weight is 400,000 hyal sodium sodium, viscosity 150 MPa.s alginate is dissolved in ultrapure water, Multican aqueous solutions with a mass concentration of 6%;

[0064](2) Mix the emulsifier in the amount of 4: 1 of 4: 1, the emulsifier is added to the liquid paraffin and n-hexane, so that the mass fraction of the emulsifier is 1%, at 50 EtOAc EtOAc EtOAc mids 0, 600 rpm, stirred, 600 rpm is stirred, and the stirring time is 2 h at room temperature, the stirring time is 2 h, resulting in an emulsifier; The mass ratio of the oil phase and the aqueous solution of the polysaccharide is 5: 1;

[0065](3) Put CUCL2The dissolved water is dissolved in a crosslinking agent having a mass concentration of 25%, a mixed agent aqueous solution, a uniform emul...

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Abstract

The invention discloses a pit-hole composite micro-nano-structure polysaccharide microsphere and a preparation method. The preparation method comprises the following steps: (1) preparing a polysaccharide water solution; (2) adding an emulsifying agent into an oil phase so as to prepare the oil phase containing the emulsifying agent, dropwise adding the polysaccharide water solution into the oil phase containing the emulsifying agent, and stirring for emulsification, so as to obtain a uniform emulsion; (3) dissolving a polyvalent metal cross-linking agent into ultrapure water to prepare a cross-linking agent water solution, dropwise adding the cross-linking agent water solution into the uniform emulsion; and (4) adding n-hexane or petroleum ether into liquid obtained in the step (3), standing until the solution is layered, pouring out an upper oil phase layer, remaining a water phase, cleaning the water phase, and carrying out freeze-drying, so as to obtain the pit-hole composite micro-nano-structure polysaccharide microsphere. The surface of the microsphere is provided with nano-scale pits, and nano-scale fine holes are formed in the surfaces of the pits; the microsphere is uniformin particle size distribution, high in porosity and water absorption rate and strong in adsorbability; and the microsphere has good biocompatibility, and hemostasis can be effectively finished within20s-50s.

Description

Technical field[0001]The present invention relates to a pit-pore composite micro-tube structure polysaccharide microspheres and preparation methods, which belong to the technical field of polymer material preparation.Background technique[0002]Natural polymer polysaccharide has the advantages of rich resources, high biocompatibility, good biocompatibility, biodegradable, high molecular polysaccharide microspheres with porous structure in hemostasis, pharmaceutical, tissue engineering bracket, protein purification, metal ion adsorption separation There is a lot of applications in the fields.[0003]Patent Application No. 201610011690.X reported a method for preparing a nuclear shell structure composite porous microsphere, which uses sodium alginate, chitosan, cellulose, gelatin, and the like, with chitosan porous microspheres. , Cellulose porous microspheres, polylactic acid porous microspheres, gelatin porous microspheres, etc. are kernels, through the duct, well-dispersible, no agglom...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L5/08C08L5/04C08L1/28C08L5/02C08L91/06C08L91/00C08K3/16B01J13/14C08J3/24A61L24/08A61L24/00
CPCA61L24/001A61L24/0036A61L24/0042A61L24/08A61L2400/04B01J13/14C08J3/246C08K2003/162C08K2003/168C08L1/286C08L5/02C08L5/04C08L5/08C08L91/06C08K3/16C08L91/00
Inventor 石长灿席光辉冯亚凯陈浩刘雯杨啸
Owner WENZHOU INST OF BIOMATERIALS & ENG
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