Tooth desensitizer penetrating into closed canaliculi dentales and preventing biomembrane from formation
A desensitizing agent and biofilm technology, applied in dental preparations, tooth protection coatings, dentistry, etc., can solve the problem that desensitizing agents cannot deeply seal small holes in teeth, and achieve excellent anti-pollution ability, good controllability, The effect of stable storage
Active Publication Date: 2019-03-29
MEIYOU XI AN BIOTECHNOLOGY CO LTD
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Problems solved by technology
[0004] The technical problem to be solved by the present invention is to overcome the shortcomings of traditional desensitizers that cannot deeply seal the small pores of the teeth, and provide a tooth desensitizer that can deeply seal the tooth tubules and maintain the curative effect for a long time. In addition, the desensitizer has anti-pollution ability , can prevent the formation of biofilm on dentin
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment 1
[0026] 40 mg of pegylated lysozyme, 10 mg of tris(2-carboxyethyl) phosphine hydrochloride, 10 mg of calcium chloride and 60 mg of sodium bicarbonate were uniformly mixed to obtain a tooth desensitizing agent.
Embodiment 2
[0028] 50 mg of pegylated lysozyme, 15 mg of tris(2-carboxyethyl) phosphine hydrochloride, 15 mg of calcium chloride and 70 mg of sodium carbonate were uniformly mixed to obtain a tooth desensitizing agent.
Embodiment 3
[0030] 60 mg of pegylated lysozyme, 20 mg of tris(2-carboxyethyl) phosphine hydrochloride, 10 mg of calcium chloride and 80 mg of sodium carbonate were uniformly mixed to obtain a tooth desensitizing agent.
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The invention discloses a tooth desensitizer penetrating into closed canaliculi dentales and preventing biomembrane from formation. The tooth desensitizer comprises pegylation protein (lysozyme, bovine serum albumin, insulin and alpha-lactalbumin), tris(2-carboxyethyl)phosphine hydrochloride, calcium chloride and a pH regulation agent. The tooth desensitizer disclosed by the invention can penetrate to be coated in small holes of teeth by methods of soaking, film coating and the like; and under saliva environment, remineralization of inner parts of the canaliculi dentales can be induced, so that the tooth desensitizer can penetrate into closed small holes. In addition, after forming the coating, the desensitizer has excellent anti-pollution capacity, can prevent biomembranes from formationon dentin, and can prevent diseases of odontophlegmon and the like from generation. The desensitizer disclosed by the invention is non-toxic and non-irritating, and has great prospects in clinical application.
Description
technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to a desensitizer for treating tooth sensitivity by using a protein coating to induce dentin remineralization. Background technique [0002] According to statistics, 15% to 57% of adults suffer from dentin hypersensitivity. The cause of dentin hypersensitivity is due to the exposure of the small pores on the dentin, and external stimuli such as cold and heat, pressure, acid, etc. can stimulate the pulp through the small pores. Sealing the pores of the teeth is the main way to reduce or cure dentin hypersensitivity. At present, commercial desensitizers such as Jiguaning, Duole Fluor, and Jinrun Dentin Protective Film can only form a layer of coating on the surface of the dentin to cover the surface of the small pores. However, this method can only be effective for a short time. Under the action of mechanical forces such as brushing and chewing, the coating will be ...
Claims
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IPC IPC(8): A61K6/00A61K6/027A61K6/02
CPCA61K6/80A61K6/831A61K6/69A61K6/20A61K6/60A61K6/70
Inventor 杨鹏李琛
Owner MEIYOU XI AN BIOTECHNOLOGY CO LTD
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