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A tooth desensitizer for deep sealing of dental tubules and prevention of biofilm formation

A desensitizing agent and biofilm technology, applied in dental preparations, tooth protection coatings, dentistry, etc., can solve the problem that desensitizing agents cannot deeply seal small holes in teeth, and achieve excellent anti-pollution ability, good controllability, Effect of preventing bacterial adhesion

Active Publication Date: 2021-05-18
MEIYOU XI AN BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to overcome the shortcomings of traditional desensitizers that cannot deeply seal the small pores of the teeth, and provide a tooth desensitizer that can deeply seal the tooth tubules and maintain the curative effect for a long time. In addition, the desensitizer has anti-pollution ability , can prevent the formation of biofilm on dentin

Method used

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  • A tooth desensitizer for deep sealing of dental tubules and prevention of biofilm formation
  • A tooth desensitizer for deep sealing of dental tubules and prevention of biofilm formation
  • A tooth desensitizer for deep sealing of dental tubules and prevention of biofilm formation

Examples

Experimental program
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Effect test

Embodiment 1

[0026] 40 mg of pegylated lysozyme, 10 mg of tris(2-carboxyethyl) phosphine hydrochloride, 10 mg of calcium chloride and 60 mg of sodium bicarbonate were uniformly mixed to obtain a tooth desensitizing agent.

Embodiment 2

[0028] 50 mg of pegylated lysozyme, 15 mg of tris(2-carboxyethyl) phosphine hydrochloride, 15 mg of calcium chloride and 70 mg of sodium carbonate were uniformly mixed to obtain a tooth desensitizing agent.

Embodiment 3

[0030] 60 mg of pegylated lysozyme, 20 mg of tris(2-carboxyethyl) phosphine hydrochloride, 10 mg of calcium chloride and 80 mg of sodium carbonate were uniformly mixed to obtain a tooth desensitizing agent.

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Abstract

The invention discloses a tooth desensitizing agent for deeply sealing tooth tubules and preventing biofilm formation, which comprises pegylated protein (lysozyme, bovine serum albumin, insulin, α-lactalbumin), tris(2 -Carboxyethyl)phosphine hydrochloride, calcium chloride, pH adjuster. The tooth desensitizing agent of the present invention can be deeply coated inside the small pores of the teeth by soaking, coating and other methods; in the saliva environment, it can induce remineralization inside the small tubes of the teeth, thereby deeply sealing the small pores. In addition, after forming a coating, the desensitizing agent of the present invention has excellent anti-pollution ability, can prevent the formation of biofilm on dentin, and prevent the generation of diseases such as pulpitis. The desensitizing agent of the invention is non-toxic and non-irritating, and has wide prospects in clinical application.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to a desensitizer for treating tooth sensitivity by using a protein coating to induce dentin remineralization. Background technique [0002] According to statistics, 15% to 57% of adults suffer from dentin hypersensitivity. The cause of dentin hypersensitivity is due to the exposure of the small pores on the dentin, and external stimuli such as cold and heat, pressure, acid, etc. can stimulate the pulp through the small pores. Sealing the pores of the teeth is the main way to reduce or cure dentin hypersensitivity. At present, commercial desensitizers such as Jiguaning, Duole Fluor, and Jinrun Dentin Protective Film can only form a layer of coating on the surface of the dentin to cover the surface of the small pores. However, this method can only be effective for a short time. Under the action of mechanical forces such as brushing and chewing, the coating will be ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K6/80A61K6/831A61K6/20A61K6/69
CPCA61K6/80A61K6/831A61K6/69A61K6/20A61K6/60A61K6/70
Inventor 杨鹏李琛
Owner MEIYOU XI AN BIOTECHNOLOGY CO LTD
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