Fiber-reinforced compound hydrogel artificial blood vessel structure and molding method thereof

A technology of fiber-reinforced composite and artificial blood vessels, which is applied in the direction of human tubular structure devices, blood vessels, and pharmaceutical formulations. The effect of overall structural stability

Inactive Publication Date: 2019-04-26
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, artificial blood vessels are mostly made of synthetic materials such as nylon, polyester, and polytetrafluoroethylene. For artificial blood vessels with a diameter of more than 6mm, satisfactory results have been achieved in clinical practice; but for small-diameter blood vessels below 6mm, Due to material and structural factors, the current artificial blood vessels are prone to restenosis after transplantation, and the medium and long-term treatment effect is not good, so that the small-caliber (inner diameter <6mm) artificial blood vessels mainly used in peripheral blood vessel replacement surgery are still not available clinically. The product
[0004] In addition, the current artificial blood vessel material is a non-degradable material and does not have growth properties. It always exists as a foreign body after being transplanted into the human body. For pediatric patients who cannot meet the growth and development requirements, most patients need to be replaced according to their physical development. Bring pain and economic burden to patients

Method used

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  • Fiber-reinforced compound hydrogel artificial blood vessel structure and molding method thereof
  • Fiber-reinforced compound hydrogel artificial blood vessel structure and molding method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] In this embodiment, the equipment composition includes the following contents: take a stainless steel optical shaft with a diameter of 5mm as the mandrel, and connect it to 42 stepper motors through a coupling, and the controller of the stepper motor is a single-chip microcomputer (the single-chip microcomputer model is 89C51 ), the single-chip microcomputer can control the rotation mode of the motor, which is divided into continuous operation and single-step operation, and can realize the conversion and speed regulation of the two. The axis is installed on the y-axis motion platform of the three-axis platform. Electrospinning and electrostatic direct writing nozzles are installed on the x-z motion platform of the three-axis motion platform. The nozzle is a 10ml medical disposable syringe. The material of the nozzle is 10% wt PCL (polycaprolactone dissolved in a solvent of dichloromethane: dimethylamide = 7:3), and the supply of the nozzle is provided by a micropump thr...

Embodiment 2

[0063] The equipment composition of this embodiment is the same as that of Embodiment 1.

[0064] A method for forming a fiber-reinforced composite hydrogel artificial blood vessel structure, the specific steps are as follows:

[0065] 1) Select a mandrel with a diameter of <6mm as the central axis of the artificial blood vessel, and use electrostatic direct writing technology to electrostatically write PCL fibers with a diameter of 30um on the mandrel. The fibers are arranged in parallel along the axis of the mandrel to form electrostatic direct writing fibers. Layer 1 1; adjust the relevant parameters of electrostatic direct writing: the distance between the needle and the mandrel is 4mm, the feeding speed is 1ml / h, the moving speed of the nozzle along the mandrel is 35mm / s, and the voltage applied to the needle is 2.5kv; Directly write the fiber The length of a single fiber is 10mm, and the distance between each fiber is 15um;

[0066] 2) Utilize the electrospinning techno...

Embodiment 3

[0073] The equipment composition of this embodiment is the same as that of Embodiment 1.

[0074] A method for forming a fiber-reinforced composite hydrogel artificial blood vessel structure, such as figure 2 As shown, the specific steps are as follows:

[0075] 1) Select a mandrel with a diameter of <6mm as the central axis of the artificial blood vessel, and use electrostatic direct writing technology to electrostatically write PCL fibers with a diameter of 50um on the mandrel. The fibers are arranged in parallel along the axis of the mandrel to form electrostatic direct writing fibers. Layer 1 1; adjust the relevant parameters of electrostatic direct writing: the distance between the needle and the mandrel is 7mm, the feeding speed is 2ml / h, the moving speed of the nozzle along the mandrel is 70mm / s, and the voltage applied to the needle is 4kv; The length of the root is 150mm, and the distance between each fiber is 100um;

[0076] 2) Utilize electrospinning technology, ...

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Abstract

The invention discloses a fiber-reinforced compound hydrogel artificial blood vessel structure and a molding method thereof. The fiber-reinforced compound hydrogel artificial blood vessel structure comprises a first static direct-writing fiber layer, a first electrostatic spinning layer, a first hydrogel layer, a second static direct-writing fiber layer, a second hydrogel layer and a second electrostatic spinning layer in turn from inner to outer; the first static direct-writing fiber layer is arrayed in parallel along the axial direction of blood vessel; the second static direct-writing fiberlayer is spirally crossed along a blood vessel wall. The fiber-reinforced compound hydrogel artificial blood vessel structure disclosed by the invention has appropriate degradation rate, high biocompatibility, certain mechanical properties, appropriate elasticity and capability of guiding growth of vascular cells.

Description

technical field [0001] The invention relates to the technical field of preparation and additive manufacturing of small-diameter artificial blood vessels, and more specifically relates to a fiber-reinforced composite hydrogel artificial blood vessel structure and a forming method thereof. Background technique [0002] Cardiovascular disease has become one of the common diseases that endanger human life and health. For patients with serious conditions, blood vessel transplantation is required. The source of autologous blood vessels is severely limited, and there is a serious rejection of allogeneic blood vessels, which requires artificial blood vessels to replace autologous blood vessels. transplant treatment. [0003] At present, artificial blood vessels are mostly made of synthetic materials such as nylon, polyester, and polytetrafluoroethylene. For artificial blood vessels with a diameter of more than 6mm, satisfactory results have been achieved in clinical practice; but fo...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/20A61L27/18A61L27/16A61L27/22A61L27/50A61L27/58A61F2/06
CPCA61F2/06A61L27/16A61L27/18A61L27/20A61L27/222A61L27/50A61L27/507A61L27/58A61L2400/12C08L67/04C08L5/04C08L29/04
Inventor 刘媛媛汪羽王斌蒲华燕罗均谢少荣彭艳
Owner SHANGHAI UNIV
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