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Preparation method and application of medical magnesium-based metal coating with stress-corrosion-resisting and self-repairing functions

A magnesium-based metal, self-healing technology, applied in coating, medical science, surgery, etc., can solve the problem of effectively inhibiting anodic dissolution stress corrosion cracking mechanism, coating components containing toxic or carcinogenic substances, hydrogen-induced stress corrosion cracking Problems such as limited restraint ability

Active Publication Date: 2019-04-26
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, most of the existing self-healing coatings are used as a physical shielding layer, which cannot effectively inhibit the anodic dissolution-type stress corrosion cracking mechanism for a long time, and the ability to inhibit hydrogen-induced stress corrosion cracking caused by a small amount of hydrogen generated by corrosion reactions is also very limited.
Moreover, most self-healing coatings are used in the field of engineering structural materials, and their coating components may contain toxic or carcinogenic substances, which are no longer suitable as biomedical modified coatings

Method used

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  • Preparation method and application of medical magnesium-based metal coating with stress-corrosion-resisting and self-repairing functions
  • Preparation method and application of medical magnesium-based metal coating with stress-corrosion-resisting and self-repairing functions
  • Preparation method and application of medical magnesium-based metal coating with stress-corrosion-resisting and self-repairing functions

Examples

Experimental program
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Effect test

Embodiment 1

[0090] The commercially available extruded WE43 magnesium alloy is selected as the base material, and the process of preparing an anti-stress corrosion self-repairing coating on the surface of the magnesium alloy is as follows:

[0091] (1) Pretreatment: Grind the magnesium alloy with 400#, 800#, 1200#, 1500# and 2000# sandpaper (that is, mechanically polish and polish silicon carbide water sandpaper), rinse with deionized water, and then put in acetone Ultrasonic cleaning in medium for 10 minutes, then rinse with deionized water, pickle with a mixed solution of 200 mg / mL acetic acid and 60 mg / mL sodium nitrate at a final concentration of 0.5 minutes, then ultrasonically clean with deionized water for 10 minutes, deionized water Rinse, dry in a vacuum oven at 60°C, and set aside.

[0092] (2) Hydroxylation treatment: Soak the magnesium alloy obtained in step (1) in 50° C. sodium hydroxide solution of 5mol / L for 2 hours, carry out hydroxylation treatment, obtain a large amount ...

Embodiment 2

[0099] The commercially available ZK40 magnesium alloy is selected as the base material, and the process of preparing an anti-stress corrosion self-repairing coating on the surface of the magnesium alloy is as follows:

[0100] (1) Pretreatment: Grind the magnesium alloy with 400#, 800#, 1200#, 1500# and 2000# sandpaper (that is, mechanically polish and polish silicon carbide water sandpaper), rinse with deionized water, and then put in acetone Ultrasonic cleaning in medium for 10 minutes, then rinse with deionized water, pickle with a mixed solution of 200mg / mL acetic acid and 60mg / mL sodium nitrate for 0.5 minutes, then ultrasonically clean with deionized water for 10 minutes, rinse with deionized water, vacuum Dry in a drying oven at 60°C for use.

[0101] (2) Hydroxylation treatment: Soak the magnesium alloy obtained in step (1) in 3mol / L 80°C sodium hydroxide solution for 1.5 hours, carry out hydroxylation treatment, obtain a large amount of basic hydroxyl groups on the s...

Embodiment 3

[0107] The commercially available AZ31 magnesium alloy is selected as the substrate, and the process of preparing an anti-stress corrosion self-repairing coating on the surface of the magnesium alloy is as follows:

[0108] (1) Pretreatment: Grind the magnesium alloy with 400#, 800#, 1200#, 1500# and 2000# sandpaper (that is, mechanically polish and polish silicon carbide water sandpaper), rinse with deionized water, and then put in acetone Ultrasonic cleaning in medium for 10 minutes, then rinse with deionized water, pickle with a mixed solution of 200 mg / mL acetic acid and 60 mg / mL sodium nitrate at a final concentration of 0.5 minutes, then ultrasonically clean with deionized water for 10 minutes, deionized water Rinse, dry in a vacuum oven at 60°C, and set aside.

[0109] (2) Hydroxylation treatment: Soak the magnesium alloy obtained in step (1) in 3mol / L 80°C sodium hydroxide solution for 1.5 hours, carry out hydroxylation treatment, obtain a large amount of basic hydroxy...

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Abstract

The invention discloses a preparation method and application of a medical magnesium-based metal coating with stress-corrosion-resisting and self-repairing functions. The method comprises the followingsteps: taking medical magnesium-based metal as a matrix; firstly, pre-treating to remove machining residues and surface attached matters; then putting into a sodium hydroxide solution and carrying out hydroxylation treatment; then coating the surface of the matrix with a corrosion inhibitor; and carrying out heat treatment and curing to form the coating with the stress-corrosion-resisting and self-repairing functions, wherein the corrosion inhibitor is prepared from three components including a silane coupling agent, phytic acid and graphene oxide. A preparation technology of the coating involved in the invention is simple in method and easy to operate; the obtained coating has good bonding strength and good biocompatibility and has a self-repairing capability in a physiological environment; the corrosion-resisting performance of a magnesium alloy can be improved and the stress corrosion sensitivity can be inhibited; and therefore, the prepared magnesium-based metal with the protection coating as a medical implantable device material can be applied in the clinical aspect.

Description

technical field [0001] The invention belongs to the field of implantable medical devices, in particular to a preparation method and application of a medical magnesium-based metal anti-stress corrosion self-repairing functional coating. Background technique [0002] Traditional biomedical metal materials have been widely used because of their excellent corrosion resistance and stable mechanical properties, such as stainless steel, titanium alloy and cobalt-chromium alloy. However, these traditional inert metal devices remain in the body for a long time, which may cause problems such as chronic inflammation, late stent thrombosis, and the need to take anticoagulant drugs for a long time; at the same time, for temporary fixation or support implant materials in the body, they need to be treated twice after tissue healing. Surgical removal will bring secondary injury and medical burden to the patient. Biomedical degradable magnesium alloys have become a hotspot in research and d...

Claims

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Application Information

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IPC IPC(8): A61L31/02A61L31/14A61L31/08A61L31/16C23F11/10
CPCA61L31/022A61L31/08A61L31/084A61L31/14A61L31/16A61L2300/216A61L2300/416A61L2300/42A61L2300/422A61L2420/06C23F11/10
Inventor 陈连喜王小健李卫
Owner JINAN UNIVERSITY
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