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Implant comprising a calcium salt-containing composite powder having microstructred particles

A technology for composite powders and implants, used in calcium/strontium/barium compounds, drug combinations, household appliances, etc., can solve the problems of component surface quality and surface finish, component density is not completely satisfactory, and achieve good handleability. high quality, high body compatibility

Active Publication Date: 2019-04-26
卡尔莱布宁医疗技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While sintering of ground composite particles is feasible, the surface quality and surface finish of the resulting components and component density are not entirely satisfactory

Method used

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  • Implant comprising a calcium salt-containing composite powder having microstructred particles
  • Implant comprising a calcium salt-containing composite powder having microstructred particles
  • Implant comprising a calcium salt-containing composite powder having microstructred particles

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0343] a CO 2 Gas mixture with 20% CO 2 and 80% N2 were introduced into 4 l of calcium bicarbonate suspension with a concentration of 75 g / l CaO at an initial temperature of 10°C. The gas flow rate is 300 l / h. The reaction mixture was stirred at 350 rpm and the heat of reaction was removed during the reaction. When the conductivity drops suddenly (the drop rate is greater than 0,5mS / cm / min and the drop value within 30 seconds is greater than 0,25mS / cm), refer to CaO (as a theoretical reference amount) to add 0.7% amino tri (methylene phosphine acid) was added to the suspension. When the reaction mixture is quantitatively carbonated into spherical calcium carbonate particles, the reaction to produce spherical calcium carbonate particles is complete. Wherein, the pH value of the reaction mixture at this moment is between 7 and 9. In the above case, the reaction was completed after approximately 2 hours and the pH of the reaction mixture was 7 at the end of the reaction.

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example 2

[0346] 500ml of completely decalcified water is placed in a 1000ml beaker, while stirring, add 125g according to the spherical calcium carbonate particles of example 1 gained, and continue to stir the gained mixture for 5 minutes, slowly add 37.5g of 10% sodium metaphosphate ( NaPO 3 )n solution, and continued to stir the resulting mixture for 10 minutes, slowly added 75,0 g of 10% concentration of phosphoric acid, and continued to stir the resulting mixture for 20 hours. The precipitate was separated and dried overnight in a drying oven at a temperature of 130°C. The resulting spherical calcium carbonate particles likewise had an average particle diameter of 12 μm.

[0347] The REM image of spherical calcium carbonate particles as figure 2 shown. A thin layer of phosphate can be discerned on the surface of the spherical calcium carbonate particles.

example 3

[0349] A composite powder of spherical calcium carbonate particles and a polylactide (PLLA) can be prepared using equipment NHS-1 by referring to the method described in JP 62083029A. The composite powder was cooled with cold water at 12°C. A polylactide particle 1 was used as a master batch and the calcium carbonate particle in Example 1 was used as a child particle (filler).

[0350] 39,5g of polylactide pellets with 26.3g of CaCO 3 The powders were mixed and filled at a rotational speed of 6400 U / min. The rotor speed of the device was set at 6400U / min (80m / s) and the added material was processed for 10 minutes. The NHS-1 grinding chamber reaches a maximum temperature of 35°C. A total of 7 runs were repeated with the same amount of material and machine settings. A total of 449 g of composite powder was obtained. The resulting composite powder was manually dry sieved through a 250um sieve. Sieve residue (size >250 μm) accounted for 0.4%.

[0351] The resulting composit...

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Abstract

The invention relates to an implant comprising a composite powder having micro-structured particles, obtained by a method in which large particles are joined to small particles, wherein the large particles have an average particle diameter in the range from 10 [mu]m to 10 mm, the large particles comprise at least one polymer, the small particles are arranged on the surface of the large particles and / or distributed non-homogenously within the large particles, the small particles comprise a calcium salt, the small particles have an average particle size in the range from 0.01 [mu]m to 1.0 mm, wherein the particles of the composite powder have an average particle size (d50) in the range from 10 [mu]m to less than 200 [mu]m, and the fine-grain proportion of the composite powder is less than 50% by volume. The subject of the invention is therefore further implants obtained by selective laser sintering of a composition comprising a composite powder, in particular as an implant for applications in the area of neuro-surgery, oral, jaw, face, neck and ear surgery, and in hand, foot, thorax, rib, and shoulder surgery.

Description

technical field [0001] The invention relates to an implant with a calcium salt-containing composite powder obtained by selective laser sintering and used in particular in neurosurgery, oral surgery, maxillofacial surgery, facial surgery, throat surgery, Nasal surgery and ear surgery, as well as areas such as hand and foot surgery, thoracic surgery, rib surgery and shoulder surgery. [0002] The present invention does not relate to the preparation of raw materials for said implants, nor does it relate to surgical procedures other than the production of implants, especially for the nerves, mouth, jaw, face, larynx, nose and ears, as well as for hands, feet, ribs and shoulders. Implants prepared for surgery, other than the application of the purpose. Background technique [0003] Calcium carbonate, CaCO 3 , is a calcium salt of carbonate that is currently used in many areas of daily life. Especially it can be used as an additive or modifier in paper, pigment, synthetic mater...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44C01F11/18C08J3/12C08J3/20C09C1/00C09C1/02C08L67/04C08L67/02A61K6/838A61K6/884A61K6/891
CPCA61L27/446C01F11/183C09C1/0081C09C1/021A61P1/02A61P19/08A61P25/00A61L27/40A61L27/44C01F11/18C08L67/02C08L67/04C09C1/00C09C1/02C08J3/12B33Y10/00B33Y70/00B33Y80/00A61L27/443A61L27/46B29K2067/046B29K2075/00B29K2077/00B29K2103/04C01P2004/03C01P2004/32C01P2004/61C01P2004/62C01P2004/64C01P2004/80C09C1/024C09D11/037C09D11/102C09D11/104
Inventor 弗兰克·赖瑙尔西格蒙德·鲁格马里扬·瓦卡克
Owner 卡尔莱布宁医疗技术有限公司
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