Condensed ring aromatic hydrocarbon based amide embedded type liquid chromatography stationary phase synthesis method

Abstract

The invention relates to a novel condensed ring aromatic hydrocarbon based amide embedded type liquid chromatography stationary phase synthesis method. According to the condensed ring aromatic hydrocarbon based amide embedded type liquid chromatography stationary phase synthesis method, condensed ring aromatic hydrocarbon based carboxylic acids and isocyanate silane reagents are taken as raw materials, amide type silane reagents are synthesized, simple purification is adopted, modification onto stationary phase matrix surfaces is realized so as to synthesize a condensed ring aromatic hydrocarbon based amide embedded type liquid chromatography stationary phase. The properties such as bonding density, aromatic and hydrophobic compound separation effect, charge transfer capacity, and isomer selectivity are tested, it is shown that better aromatic compound selectivity and shape selectivity are achieved.

Description

technical field [0001] The method of the invention relates to a new way to synthesize a condensed ring aromatic hydrocarbon base amide embedded liquid chromatography stationary phase. Background technique [0002] The stationary phase of high performance liquid chromatography is generally prepared by condensing different chlorosilanes or alkoxysilanes with silanols on the surface of silica gel to form siloxanes, and the bonding units are connected to silica gel with covalent chemical bonds. The properties of organic bonded phases, such as bonded body size, bonded phase density, thickness, configuration, mobility, and arrangement, have a major impact on the interaction between analyte and stationary phase. Among the various chemically bonded stationary phases, the alkyl bonded stationary phase, especially the C18 bonded silica gel, is the most successful reversed-phase stationary phase so far, and is well-known in the chromatographic field. [0003] Despite the excellent chr...

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Problems solved by technology

[0010] In summary, it can be seen that C. H. Lochmuller et al. have too many synthesis steps, and the process is complex and cumbersome; Feng Yuqi et al. used two methods that are three-step synthesis of pyrenyl-modified chromatographic stationary phases, and the synthesis steps are also relatively cumbersome.

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