Preparation method of gelatin methacrylamide core-shell microsphere based on microfluidics technique

A technology of gelatin methacrylamide and microfluidic technology, which is applied in the direction of microsphere preparation, microcapsule preparation, chemical instruments and methods, etc., can solve the problems of cumbersome methods, achieve good size controllability, uniform size, and system Uniform and stable effect

Active Publication Date: 2019-05-28
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
View PDF8 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the construction of the core-shell structure mostly adopts the sleeve device, which is prepared by multi-steps, that is, the small droplets formed in the upstream are swallowed by the large droplets in the downstream, and after the core-shell structure is formed, the shell is solidified to form the core-shell microspheres. The method is more cumbersome

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of gelatin methacrylamide core-shell microsphere based on microfluidics technique
  • Preparation method of gelatin methacrylamide core-shell microsphere based on microfluidics technique
  • Preparation method of gelatin methacrylamide core-shell microsphere based on microfluidics technique

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A kind of microfluidic chip of the present invention, such as figure 1 As shown, it is mainly composed of continuous phase inlet 1, shell fluid inlet 2, core fluid inlet 3, microsphere outlet 4, continuous phase channel 5, shell fluid channel 6, core fluid channel 7, laminar flow channel 8 and main channel 9;

[0025] The continuous phase inlet 1 is connected with the main channel 8 through the continuous phase channel 5, and the shell fluid inlet 2 and the core fluid inlet 3 are respectively connected with the laminar flow channel 8 and the main channel 9 through the shell fluid channel 6 and the core fluid channel 7;

[0026] In the microfluidic chip, the height and width of the continuous phase channel 5 are 310 μm and 270 μm respectively, the height and width of the shell fluid channel 6 are 150 μm and 150 μm respectively, the height and width of the core fluid channel 7 are 150 μm and 130 μm respectively, and the laminar flow channel The height and width of 8 are 1...

Embodiment 2

[0036] The present invention is a method for preparing gelatin methacrylamide core-shell microspheres based on microfluidic technology. The microfluidic chip is mainly composed of continuous phase inlet 1, shell fluid inlet 2, core fluid inlet 3, microsphere outlet 4, Composed of continuous phase channel 5, shell fluid channel 6, core fluid channel 7, laminar flow channel 8 and main channel 9;

[0037] The continuous phase inlet 1 is connected to the main channel 8 through the continuous phase channel 5, and the shell fluid inlet 2 and the core fluid inlet 3 are respectively connected to the laminar flow channel 8 and the main channel 9 through the shell fluid channel 6 and the core fluid channel 7;

[0038] In the microfluidic chip, the height and width of the continuous phase channel 5 are 310 μm and 270 μm respectively, the height and width of the shell fluid channel 6 are 150 μm and 150 μm respectively, the height and width of the core fluid channel 7 are 150 μm and 130 μm ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
heightaaaaaaaaaa
diameteraaaaaaaaaa
thicknessaaaaaaaaaa
Login to view more

Abstract

The invention discloses a preparation method of a gelatin methacrylamide core-shell microsphere based on a microfluidics technique. A microfluidics chip mainly consists of a continuous phase inlet, ashell fluid inlet, a shell fluid inlet, a microsphere outlet, a continuous phase channel, a shell fluid channel, a shell fluid channel, a laminar flow channel and a main channel. The preparation method of the core-shell microsphere using the chip mainly comprises the following steps of synthesizing of a gelatin methacrylamide material, and preparation of the gelatin methacrylamide core-shell microsphere. The preparation method provided by the invention has the advantages that the laminar flow property and oil-water interface tension of the two-phase water solution are utilized, the core-shellliquid droplets are formed on the microfluidics chip in one step, the cured gelatin methacrylamide shell is formed by photo-chemical crosslinking, and the core is the water solution; the technique canbe applied to the biology application, such as construction of in-vivo microtissue models,angiogenesis, and transplanting of tissue blocks.

Description

technical field [0001] The invention relates to the field of material chemistry and microfluidic technology, in particular to a method for preparing gelatin methacrylamide core-shell microspheres based on microfluidic technology. Background technique [0002] Microfluidic technology, also known as lab-on-a-chip, is a science and technology whose main feature is the manipulation of fluids in the micron-scale space. Microfluidic droplet technology is an important branch of it. It is a technology that uses the principle of fluid incompatibility to form droplets and then manipulates them for subsequent sorting, splitting, capturing, and fusion. Microfluidic droplet technology has the advantages of uniform size, high throughput; small volume, fast heat and mass transfer; monodisperse, no cross-contamination; time-space resolution, conducive to multi-step, multi-reagent synthesis; scale integration, flexible use, etc. , this technology has been widely used in microparticle synthe...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00B01J13/20B01J13/14C08G81/02C08F289/00C08F220/08A61L27/56A61L27/22A61L27/50A61L27/52
Inventor 秦建华王慧魏文博
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap