A heat-insulating coating material for medical catheters and its preparation method and application

Abstract

The invention relates to the field of medical materials and discloses a heat-insulating coating material for medical catheters and a preparation method and application of the heat-insulating coating material. The heat-insulating coating material contains biopolymers and hollow silica nanospheres and is prepared with the method including: adding the hollow silica nanospheres to an aqueous solutionof biopolymers with the mass volume fraction of 6%-7% by stirring; meanwhile, adding a plasticizer of 1%-2% volume relative to a silk fibroin solution. When the heat-insulating coating material is applied to the endovascular intervention-like medical catheters, and a heat insulating coating formed by the heat-insulating coating material can effectively slow down the heat exchange rate between perfusion fluid and blood in the catheters, reduce the temperature difference between inlet and outlet perfusion liquid of the catheters and improve the effectiveness and accuracy of local targeted therapy.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a heat-insulating coating material for medical catheters, a preparation method and application thereof. Background technique [0002] In recent years, with the development of endovascular interventional biomedical materials, vascular recanalization therapy represented by mechanical thrombectomy can effectively reduce the volume of cerebral infarction and improve the long-term prognosis of patients with acute ischemic stroke. Mild hypothermia therapy is currently the most promising neuroprotective method, and it is also the only clinically proven effective treatment method for global ischemic brain injury after cardiopulmonary resuscitation. Clinical studies have confirmed that mild hypothermia therapy based on vascular recanalization has obvious cerebral protective effects on patients with acute ischemic stroke. [0003] There are many ways of mild hypothermia therapy, among whi...

AI Technical Summary

Problems solved by technology

The main problems restricting the clinical transformation of this technology are as follows: (a) All catheters currently used in clinical practice do not consider heat insulation design, and there is inevitably a heat exchange process between the perfusate, catheter and blood, which makes the temperature of the low-temperature perfusate rise significantly. High, low temperature efficiency is greatly reduced, (b) at the same time, when the perfusate is delivered to the affected site, it will mix with the autologous blood in the surrounding blood vessels, further increasing its temperature and reducing the therapeutic effect; clinically try to use lower temperature perfusate , increase the perfusion speed to shorten the residence time of the perfusate in the catheter to alleviate its temperature rise, (c) but the former is prone to adverse reactions such as excessive drop in autologous blood temperature due to heat transfer, and (d) the latter is likely to cause Problems such as rupture of blood vessels at the perfusion site

At present, there are few reports on the research on biomedical thermal insulation coatings for intravascular intervention at home and abroad. Traditional thermal insulation coatings are usually SiC, SiO 2 、Al 2 o 3 and other inorganic ceramic materials and resin-based materials such as phenolic resin and epoxy resin. However, this type of coating not only has a complicated preparation process, high temperature treatment, thick coating, poor toughness, low flexural strength, and poor biocompatibility, it is not suitable for Surface insulation coating for preparation of biomedical interventional catheters

Images