Unlock instant, AI-driven research and patent intelligence for your innovation.

Medical instrument composition and method for preparing same

A technology of composition and medical device, which is applied in the field of medical device composition and its preparation, can solve the problems that slow and controlled release preparations cannot achieve stable and uniform release, and achieve the effects of wide application range, simple preparation method and strong operability

Active Publication Date: 2019-06-14
HEBEI UNIVERSITY
View PDF4 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] One of the objectives of the present invention is to provide a medical device composition to solve the problem that the existing sustained and controlled release preparations cannot achieve stable and uniform release for several days after administration

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medical instrument composition and method for preparing same
  • Medical instrument composition and method for preparing same
  • Medical instrument composition and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Dissolve huperzine A in methanol to form a 250mg / ml solution. Use a 1ml syringe to transfer an appropriate amount of the mixture into a PVC cylinder mold and place it until the solvent evaporates. Avoid air bubbles during the operation. The cylinder mold has an outer diameter of 4.5 mm, height 3mm, each mold contains huperzine A powder 3mg.

[0053] Disperse the photocurable resin and PEG400 into the ethanol solution according to the mass ratio of 10:3, mix for 10 minutes, and then drop into the mold, so that each mold contains 24mg of photocurable resin and 7.2mg of PEG400, and irradiate with a photocuring machine after the solvent is volatilized The resin layer was cured for 30 seconds.

[0054] The sample was placed in a shaker by direct release method for in vitro release test. In vitro release test measurement process: put the prepared medical device composition into a 100ml glass bottle, add 10ml of distilled water as the release medium, the temperature is 37°C, ...

Embodiment 2

[0056] Dissolve huperzine A in methanol to form a 250mg / ml solution. Use a 1ml syringe to transfer an appropriate amount of the mixture into a PVC cylinder mold and place it until the solvent evaporates. Avoid air bubbles during the operation. The cylinder mold has an outer diameter of 4.5 mm, height 3mm, each mold contains huperzine A powder 3mg.

[0057] Disperse the photocurable resin and PVP K30 into the ethanol solution according to the mass ratio of 10:3, mix for 10 minutes, and then drop into the mold, so that each mold contains 24mg of photocurable resin and 7.2mg of PVP K30. The machine irradiated the resin layer for 30 seconds to cure.

[0058] The sample was placed in a shaker by direct release method for in vitro release test. The determination process of the in vitro release test is the same as in Example 1.

Embodiment 3

[0060] Dissolve huperzine A in methanol to form a 250mg / ml solution. Use a 1ml syringe to transfer an appropriate amount of the mixture into a PVC cylinder mold and place it until the solvent evaporates. Avoid air bubbles during the operation. The cylinder mold has an outer diameter of 4.5 mm, height 3mm, each mold contains huperzine A powder 3mg.

[0061] Disperse the photocurable resin and Poloxamer 188 into the ethanol solution according to the mass ratio of 10:3, mix for 10 minutes, and then drop into the mold, so that each mold contains 24mg of photocurable resin and 7.2mg of Poloxamer 188. The machine irradiated the resin layer for 30 seconds to cure. The sample was placed in a shaker by direct release method for in vitro release test.

[0062] The sample was placed in a shaker by direct release method for in vitro release test. The determination process of the in vitro release test is the same as in Example 1.

[0063] Embodiment 1~3 in vitro release experiment gaine...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
surface areaaaaaaaaaaa
depthaaaaaaaaaa
Login to View More

Abstract

The invention provides a medical instrument composition and a method for preparing the same. The medical instrument composition comprises a die, a medicine layer and a photocurable resin controlled-release layer. The medicine layer and the photocurable resin controlled-release layer are disposed in the die, the photocurable resin controlled-release layer is disposed on the outer side of the medicine layer, and the medicine layer comprises an active medicine or a mixture of an active medicine and auxiliaries. The photocurable resin controlled-release layer comprises a mixture of a light-cured resin and a pore-forming agent. The ratio of the mass of the light-cured resin to the mass of the pore-forming agent is 0.5:1-100:1. The method for preparing the medical instrument composition is simple, high in operability, convenient to use and low in cost, the raw materials used are safe and non-toxic, and the types of medicines in the medicine layer can be selected freely, the speed of medicinerelease can be adjusted flexibly by adjusting parameters such as the thickness of the photocurable resin controlled-release layer and the content of the pore-forming agent, which is favorable for achieving smooth and slow release of the medicine to achieve the therapeutic and / or health-care goals, and the application range is wide.

Description

technical field [0001] The invention relates to a composition, in particular to a medical device composition and a preparation method thereof. Background technique [0002] Compared with common formulations, the oral sustained-release drug delivery system has reduced the frequency of administration and can significantly increase patient compliance. Therefore, it has exerted great therapeutic advantages in the past few decades. In recent years, sustained-release pharmaceutical preparations have the characteristics of fewer administration times, less fluctuations in peak and valley blood drug concentrations, mild gastrointestinal irritation, long curative effect, and safety, which have attracted more and more clinical attention. With the wide application of materials and the in-depth study of drug delivery systems, the sustained and controlled release pharmaceutical preparations are increasing day by day, and the development and design of sustained and controlled release prepa...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/10A61K47/32A61K31/4748A61K31/18
Inventor 胡连栋
Owner HEBEI UNIVERSITY