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Body temperature stimulating shape memory hydrogel for hemangioma embolization, preparation method and applications thereof

A hydrogel and hemangioma technology, applied in medical science, surgery, etc., can solve the problems of low filling rate of metal spring coils, and achieve the effect of simple preparation method, low filling rate and easy recanalization, and excellent shape memory function

Active Publication Date: 2019-06-25
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] High recanalization rate is one of the serious problems to be solved in the treatment of aneurysms by transcatheter aneurysm embolization, which is the result of the low filling rate caused by the extremely high rigidity of commercial metal coils

Method used

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  • Body temperature stimulating shape memory hydrogel for hemangioma embolization, preparation method and applications thereof
  • Body temperature stimulating shape memory hydrogel for hemangioma embolization, preparation method and applications thereof
  • Body temperature stimulating shape memory hydrogel for hemangioma embolization, preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Step 1: Weigh 0.5g of acrylamide and 0.1875g of polyethylene glycol dimethacrylate with an analytical balance, put them in a 10ml centrifuge tube, and then use a pipette to measure 5.063ml of DMSO to dissolve them completely. Add 1ml of acrylonitrile, then add 0.0075g of BPO, mix again, blow nitrogen for 10min to remove oxygen.

[0035] Step 2: After adding 1 μL of DMA and mixing, immediately draw the solution in the centrifuge tube into the capillary with a 10ml syringe, seal both ends with a hemostat, place it in a 25°C incubator for 24 hours, and then take it out.

[0036] Step 3, then tear the tetrafluoroethylene capillary, carefully take out the gel sample, wind it on a steel rod with a length of 10 cm and a diameter of 1 mm, and fix it into a spring shape by soaking in phosphate buffered saline (PBS) at 25 °C . During the above soaking process, the PBS needs to be replaced every 12 hours for a total of 7 days to replace the organic solvent and remove residual mon...

Embodiment 2

[0039] Step 1: Weigh 0.5g of acrylamide and 0.2g of polyethylene glycol dimethacrylate with an analytical balance, put them in a 10ml centrifuge tube, and then use a pipette to measure 5.0ml of DMSO to dissolve them completely. Add 1.5ml of acrylonitrile, then add 0.0075g of BPO, mix again, blow nitrogen for 12min to remove oxygen.

[0040] Step 2: After adding 0.6 μL of DMA and mixing, immediately draw the solution in the centrifuge tube into the capillary with a 10ml syringe, seal both ends with a hemostat, place it in a 22°C incubator for 26 hours, and then take it out.

[0041] Step 3, then tear the tetrafluoroethylene capillary, carefully take out the gel sample, wind it on a steel rod with a length of 12 cm and a diameter of 1.2 mm, and fix it as a spring by soaking in phosphate buffered saline (PBS) at 25 °C shape. During the above soaking process, the PBS needs to be replaced every 10 hours for a total of 10 days to replace the organic solvent and remove residual mono...

Embodiment 3

[0044] Step 1, use an analytical balance to weigh 0.5g of acrylamide and 0.15g of polyethylene glycol dimethacrylate, put them in a 10ml centrifuge tube, and then use a pipette to measure 5.1ml of DMSO to dissolve them completely. Add 0.5ml of acrylonitrile, then add 0.0075g of BPO, mix again, blow nitrogen for 8min to remove oxygen.

[0045] Step 2: After adding 1.2 μL of DMA and mixing, immediately draw the solution in the centrifuge tube into the capillary with a 10ml syringe, seal both ends with a hemostat, place it in a 26°C incubator for 22 hours, and then take it out.

[0046] Step 3, then tear the tetrafluoroethylene capillary, carefully take out the gel sample, wind it on a steel rod with a length of 8 cm and a diameter of 0.8 mm, and fix it as a spring by soaking in phosphate buffered saline (PBS) at 25 °C shape. During the above soaking process, the PBS needs to be replaced every 9 hours for a total of 5 days to replace the organic solvent and remove residual monom...

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Abstract

The invention provides a body temperature stimulating shape memory hydrogel for hemangioma embolization, a preparation method and applications thereof. The preparation method comprises: carrying out cross-linking polymerization on acrylonitrile, acrylamide and polyethylene glycol dimethacrylate in dimethyl sulfoxide under the initiation of free radical, soaking the obtained organogel in a 25 DEG Cphosphate buffer solution, respectively soaking in a barium chloride aqueous solution and a sodium sulfate aqueous solution, depositing the barium sulfate into the gel network, and re-soaking in PBSto remove impurities so as to obtain the body temperature stimulating shape memory hydrogel spring ring for hemangioma embolization. According to the present invention, the preparation method is simple, wherein the hydrogel-based embolization spring ring is firstly prepared so as to improve the defects of low filling rate and easy re-smoothing of the commercial metal spring ring; the body temperature is the stimulation source of the shape memory effect so as to achieve the bio-friendly advantage; the modulus of the hydrogel at a normal temperature is high so as to be pushed directly; and through the in situ deposition of barium sulfate, the gel can be subjected to X-ray developing, and retains the shape memory effect.

Description

technical field [0001] The present invention relates to the technical field of shape-memory hydrogel, and more specifically relates to a high-modulus, high-intensity body temperature-stimulated shape-memory hydrogel coil that can be used for hemangioma embolization and can be developed by X-rays, and a preparation method thereof. Embolization of porcine arteries shows that the hydrogel coil has a good embolization effect. Background technique [0002] High recanalization rate is one of the serious problems to be solved in the treatment of aneurysms by transcatheter aneurysm embolization, which is the result of low filling rate caused by the extremely high rigidity of commercial metal coils. The temperature-sensitive shape-memory hydrogel coil can be fixed into a rigid straight shape in PBS at 20 °C, and delivered into the artery through a catheter under the cooling of 20 °C normal saline, after encountering warm blood Quickly softens and transforms into a spring shape. Aft...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08K3/30C08F220/56C08F222/20C08F220/48A61L31/04A61L31/02A61L31/14A61L31/18
Inventor 刘文广徐子扬刘博张银宇
Owner TIANJIN UNIV
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