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Bone repair material and preparation method thereof

A technology for bone repair and mixture, applied in the field of materials, can solve the problems of space improvement and limited application of mechanical properties and biological properties, and achieve the effects of excellent mechanical properties and biological properties, promotion of bone healing, and better biological activity.

Inactive Publication Date: 2019-07-05
川北医学院附属医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in previous studies, we found that although nHA / PA66 has excellent biocompatibility and biological activity, there is still room for improvement in its mechanical and biological properties, and this defect also limits its further clinical application. application

Method used

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  • Bone repair material and preparation method thereof
  • Bone repair material and preparation method thereof
  • Bone repair material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) The selected nano-hydroxyapatite (nano-hydroxyapatite, nHA) and zirconia (yttria-stabilized tetragonal zirconia, YTZ) are both nano-scale, the particle size of nHA is 80-100nm, and the particle size of YTZ is 70-100nm; Polyamide 66 (polyamide 66, PA66), the molecular weight of PA66 is 30000, and the relative viscosity is 3.2.

[0032] (2) First, the nHA and YTZ powders were placed in a planetary ball mill at a mass ratio of 3:2 for grinding and mixing for 8 hours. Put the mixture into an alumina crucible, compact it, and place it in a numerically controlled electric furnace for high-temperature sintering. The heating steps and time parameters are: room temperature-600°C, 300 minutes; 600°C-850°C, 100 minutes; 850°C-1500°C; The temperature was maintained at 1500°C for 4 hours. After the sintering procedure was completed, the temperature was naturally lowered to 100°C before the furnace was turned on.

[0033] (3) The sintered mixture was pulverized, and the nHA / YTZ ...

experiment example 1

[0036] Mechanical property test:

[0037] Mechanical properties test According to the ISO527-2-2012 standard, the mechanical properties of bone repair materials were tested. The steps are as follows: compressive strength test, sample size: 10×10×4mm, pressurization speed: 5mm / min, compression height ratio: 50%; flexural strength test, sample size: 10×4×80mm, bending span: 60mm , Compression speed: 5mm / min, bending degree: 15mm; tensile strength, elongation at break and elastic modulus test, sample size: 10×4×100mm, gauge length: 60mm, tensile speed: 5mm / min , see Table 1 for details.

[0038] Table 1. Mechanical strength test

[0039]

[0040] It can be seen from Table 1 that compared with the existing nHA / PA66, the bone repair material prepared in Example 1 of the present invention can meet the requirements in terms of compressive strength, tensile strength, flexural strength, and elongation at break. .

experiment example 2

[0042] Fourier transform infrared spectroscopy analysis of bone repair materials, figure 1 The bone repair material infrared spectrogram that is prepared for embodiment 1; figure 1 It can be seen that the test is a test of the functional group composition of the material, indicating that the bone repair material nHA / PA66 / YTZ prepared by the method of the present invention has a stable chemical structure and no change in functional groups.

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Abstract

The invention provides a bone repair material and a preparation method thereof. The method comprises the following steps: (1) mixing nano hydroxyapatite and zirconia powder according to a certain proportion for grinding; (2) pressing a grinding mixture obtained in the step (1) into a blank and then carrying out high-temperature sintering, wherein the heating step and the time parameter are as follows: the blank is heated at the room temperature of 600 DEG C for 300 minutes; the blank is heated at the temperature of 600-850 DEG C for 100 minutes; the blank is heated at the temperature of 850-1500 DEG C; and the blank is maintained for 4 hours at the temperature of 1500 DEG C; (3) after the sintering process is finished, naturally cooling, cooling to the temperature of 100 DEG C, crushing the sintered mixture, and premixing with polyamide 66; and (4) carrying out injection molding the premixed mixture. The prepared bone repair material has excellent mechanical property and biological performance. Compared with a degradable material, the bone repair material prepared by the method has the advantages that the defects of uncontrollable degradation rate, possible cytotoxicity of degradation products or influence on osteoblast activity due to change of local pH value and the like are avoided, and meanwhile, the bone repair material has better biomechanical property.

Description

technical field [0001] The invention relates to the field of material technology, in particular to a bone repair material and a preparation method thereof. Background technique [0002] Bone defect refers to the lack of bone due to trauma, infection, surgical debridement of osteomyelitis, tumor resection, or other congenital diseases, which destroys the continuity and integrity of the bone and forms a large gap. With the increase of construction, traffic accidents and population aging, the number of patients with bone defects is increasing, which has an important impact on the quality of life of patients and the investment in social health services, especially for bone defects in load-bearing parts and large bone defects. Treatment has always been a difficult problem to be solved in orthopedics. The definition of a large bone defect is that when the length of the bone defect is equal to or greater than 1.5 times the diameter of the long bone, it is called a critical bone de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/10A61L27/18A61L27/50A61L27/54
CPCA61L27/10A61L27/12A61L27/18A61L27/50A61L27/54A61L2300/112A61L2300/216A61L2300/412A61L2430/02C08L77/00
Inventor 李毓灵蒋电明蒋科张静赵维康
Owner 川北医学院附属医院
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