A kind of environment-friendly preparation method of the intermediate of cefuroxime acid

A technology for cefuroxime acid and intermediates, which is applied in the field of environmental protection preparation of intermediates, can solve problems such as large environmental impact, unsatisfactory yield and quality, and achieves reduction of solvent residues, reduction of the amount of chloride salts and phosphates, Responsive effect
CN109988183BActive Publication Date: 2020-12-08GUANGDONG LIGUO PHARMACY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
GUANGDONG LIGUO PHARMACY
Publication Date
2020-12-08

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Abstract

The invention relates to an environmentally-friendly preparation method of an intermediate of cefuroxime acid. The method comprises the following steps: preparing an SMIA acyl chloride solution by utilizing triphosgene, preparing a D-7-ACA solution, and performing a condensation reaction on the SMIA acyl chloride solution and D-7-ACA solution to obtain DCC. The environmentally-friendly preparationmethod of the intermediate of the cefuroxime acid provided by the invention greatly reduces the amount of a chloride salt and a phosphate salt, and does not use high-boiling-point class-2 solvent dimethylacetamide (DMAC) difficult to recover and soluble in water, thereby greatly reducing environmental pressure, greatly reducing production costs, and steadily improving the product quality; the reaction for preparing the acyl chloride from the triphosgene is thorough, and the prepared acyl chloride has high purity, so that the prepared intermediate DCC also has higher purity; and the high-boiling-point class-2 solvent DMAC is not used; therefore the produced cefuroxime acid has a lower residual solvent, a residual solvent of bulk drug cefuroxime sodium and cefuroxime axetil produced by theintermediate of the cefuroxime acid is greatly reduced, the quality of the final product is better improved, and the yield is increased.
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Description

technical field

[0001] The invention relates to the technical field of medicines, in particular to an environment-friendly preparation method of an intermediate of cefuroxime acid. Background technique

[0002] Cefuroxime is a cephalosporin antibiotic developed by the British Glaxo Company and belongs to the second-generation cephalosporin. It inhibits cell division and growth by binding to penicillin-binding proteins (PBPs) on the bacterial cell membrane, and finally lyses and kills the bacteria. Cefuroxime has a broad-spectrum antibacterial effect and a wide range of applications. It can be used for respiratory infections caused by sensitive bacteria, ear, nose, throat infections, urinary tract infections, skin and soft tissue infections, bone and joint infections, gonorrhea, including sepsis and Meningeal and other infections.

[0003] Although the current production process of cefuroxime in my country has been close to the level of the original research unit after near...

Claims

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