Preparation method of self-healing hydrogel

A hydrogel and self-healing technology is applied in the field of preparation of self-healing hydrogels and achieves the effects of easy control of conditions, simple operation and mild reaction conditions

Inactive Publication Date: 2019-07-26
FUJIAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, up to now, there are no reports at home and abroad on polyacrylic acid-based hydrogels with high adhesion, high toughness, high stretch and self-healing properties.

Method used

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  • Preparation method of self-healing hydrogel
  • Preparation method of self-healing hydrogel
  • Preparation method of self-healing hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Dissolve 0.01g of dopamine in NaOH aqueous solution with pH=14, and pre-polymerize with stirring at room temperature for 10 minutes; then, add 0.25g of ammonium persulfate, 0.003g of N,N'-methylenebisacrylamide and 2.5g of acrylic acid monomer, fully After dissolving, add 20 μL of N,N,N',N'-tetramethylethylenediamine, stir evenly, and react in a water bath at 80°C for 1 hour to completely polymerize the acrylic acid monomer and dopamine, thereby obtaining , toughness and self-healing hydrogels.

[0028] After determination, the self-healing hydrogel adhered glass sheet (adhesion area 3.5mm 2 ) can withstand objects with a mass of more than 1658g. The self-healing hydrogel can be bent in any direction without breaking, and quickly restores to its original shape after the bending force is released. Its tensile elongation exceeds 4.

Embodiment 2

[0030] Dissolve 0.09g of dopamine in KOH aqueous solution with pH = 10, pre-polymerize with stirring at room temperature for 10min, then add 0.3g of ammonium persulfate, 0.015g of N,N'-methylenebisacrylamide and 7g of acrylic acid monomer to make After fully dissolving, add 800μL N,N,N',N'-tetramethylethylenediamine, stir evenly, and react in a 90°C water bath for 0.5h, so that the acrylic acid monomer and dopamine are completely polymerized, so as to obtain Hydrogels with stretch, toughness and self-healing properties.

Embodiment 3

[0032] Dissolve 0.001 g of dopamine in Na at pH = 8 2 CO 3 In the aqueous solution, stir and pre-polymerize at room temperature for 50 minutes, then add 0.09g ammonium persulfate, 0.005g N,N'-methylenebisacrylamide and 1.5g acrylic acid monomer to fully dissolve, then add 15μL N,N, N',N'-Tetramethylethylenediamine, stirred evenly, and reacted in a water bath at 20°C for 80 hours to complete the polymerization of acrylic acid monomer and dopamine, so as to obtain water with adhesion, stretching, toughness and self-healing properties gel.

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Abstract

The invention relates to a preparation method of a self-healing hydrogel and belongs to the technical field of biomedical high-molecular materials. The preparation method comprises adding dopamine into an alkaline solution so that dopamine self-polymerizes to form a dopamine prepolymer; adding N,N'-methylene bisacrylamide, ammonium persulfate, acrylic acid and N,N,N',N'-tetramethylethylenediamineso that the hydrogel is formed through polymerization of their free radicals. Compared with the prior art, the self-healing hydrogel prepared herein has the advantages that operation is simple, conditions are easy to control, the self-healing hydrogel is available for industrial production, the reaction conditions are mild, and the cost is low. Hydrogels with different adhesive features and tensile properties can be prepared according to actual needs.

Description

technical field [0001] The invention relates to a preparation method of self-healing hydrogel, which belongs to the technical field of biomedical polymer materials. Background technique [0002] Adhesive hydrogels with high water absorption and close resemblance to human tissue are important biomaterials, which have broad application prospects in various fields such as skin repair, wound dressing, wound suturing, and wearable devices. Adhesive hydrogels have superior wound coverage and tissue regeneration properties compared to sutures currently used in surgery, a time-consuming, skilled wound management method that can cause inflammation response, which in turn induces wound infection leading to scarring or wound swelling. Therefore, it is very important to develop tissue adhesives with simple operation, safety and reliability. [0003] Polyacrylic acid is a polymer with strong hydrophilicity. It is widely used in the preparation of biomedical materials such as hydrogels ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08F283/00C08F222/38C08F220/06C08G73/06C08L51/08
CPCC08F283/00C08G73/0672C08J3/075C08J2351/08C08F222/385C08F220/06
Inventor 陈钦慧陈佳文刘海清郭莹戎宇鑫刘清泉王锦明
Owner FUJIAN NORMAL UNIV
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