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Multi-stage biomimetic mineralized collagen-based skull repair implant and preparation method thereof

A technology of biomimetic mineralization and mineralization of collagen, applied in bone implants, prostheses, skulls, etc., to enhance the ability of osseointegration, promote osteogenesis, and enhance osteoconductivity

Active Publication Date: 2019-08-09
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a multi-level biomimetic mineralized collagen-based skull repair implant and its preparation method for the existing skull repair materials that are difficult to meet the requirements of the repair site for biomechanical properties and biological activity at the same time , the mechanical properties are guaranteed through the internal press-formed frame structure, while the biological activity is guaranteed through the porous layer

Method used

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  • Multi-stage biomimetic mineralized collagen-based skull repair implant and preparation method thereof
  • Multi-stage biomimetic mineralized collagen-based skull repair implant and preparation method thereof
  • Multi-stage biomimetic mineralized collagen-based skull repair implant and preparation method thereof

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preparation example Construction

[0052] The specific preparation method of the above-mentioned multi-level biomimetic mineralized collagen-based skull repair implant will be described below. Correspondingly, the present invention also provides a preparation method of such a multi-level biomimetic mineralized collagen-based skull repair implant, the process of which is as follows image 3 shown, including the following steps:

[0053] Step S1, preparation of bionic dense bone, specifically includes:

[0054] Step S1-1, heating the medical polymer material with a viscosity average molecular weight of 50000-200000 to a molten state, the heating temperature is 60-180°C (eg 60, 80, 100, 120, 140, 160 or 180°C). The medical polymer material is one of polycaprolactone (polycaprolactone, PCL), polylactic acid (polylactic acid, PLA) and its copolymer (PCL-PLA).

[0055] Step S1-2, weighing the corresponding mass of mineralized collagen powder, the mass ratio of the mineralized collagen powder to the medical polymer ...

Embodiment 1

[0074] Step S1, preparation of bionic dense bone, specifically includes:

[0075] Step S1-1, placing 5 g of polycaprolactone (PCL) with a viscosity-average molecular weight of 100,000 on a constant-temperature heating plate for heating, and setting the heating temperature to 100° C. to transform the polycaprolactone into a molten state;

[0076] Step S1-2, weighing 5g of mineralized collagen powder, and adding it to the molten polycaprolactone obtained in step S1-1, and fully mixing the two substances by mechanical stirring to form a uniform phase;

[0077] Step S1-3, uniformly transfer the mixture obtained in step S1-2 into a "well"-shaped mold, place the mold on a heating plate to maintain the temperature to maintain the operability of the mixture, and adjust the fit of the mixture and the mold by external force degree, so that it finally reaches the shape of the mold, and then remove the system from the heating plate, let it cool to room temperature, and obtain a "well"-sha...

Embodiment 2～18

[0095] Except for the contents of Table 1 below, it was performed in the same manner as in Example 1.

[0096]

[0097]

[0098] "Mass ratio A" in the table is the mass ratio of mineralized collagen and medical polymer materials in bionic compact bone; "mass ratio B" is the mass ratio of mineralized collagen and medical polymer materials in bionic porous bone; PLA-PCL is Polylactic acid-caprolactone block polymer. Among them, the test results show that the ratio of mineralized collagen and medical polymer materials in Examples 9 and 10 directly affects the efficiency and effect of mineralized collagen repair, and an excessive ratio of mineralized collagen will make the overall mechanical properties of the scaffold material Significant decline, not enough to support the strength of skull repair, while the degradation time is greatly shortened, which does not match the regeneration rate, and the material is excessively degraded before the regeneration is completed, which c...

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Abstract

The invention provides a multi-stage biomimetic mineralized collagen-based skull repair implant and a preparation method thereof. The implant comprises biomimetic compact bone for forming a frame structure and biomimetic porous bone for wrapping the frame structure, wherein the biomimetic compact bone is prepared by heating, mixing, cooling and shaping mineralized collagen and a medical high-molecular material in a mass ratio of (2:1)-(1:4); the biomimetic porous bone is prepared by freeze-drying a mixed suspension prepared from mineralized collagen and a medical high-molecular material in a mass ratio of (2:1)-(1:4), the biomimetic porous bone is provided with micron-sized communicating pores, the pore diameter distribution is 5-500 micrometers, and the porosity is 60-90%. The biomimeticcompact bone is combined with the biomimetic porous bone to prepare the multi-stage biomimetic mineralized collagen-based skull repair implant, wherein the biomimetic compact bone of the frame structure is high in mechanical strength and is used for providing mechanical support; the biomimetic porous bone is provided with the micron-sized communicating pores, quick ingrowth of new bone can be induced, and stage-by-stage bionic design from nanometer to micrometer is integrally achieved.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a multi-stage biomimetic mineralized collagen-based skull repair implant and a preparation method thereof. Background technique [0002] Skull defects are relatively common clinically, and their causes may be congenital defects such as cranial insufficiency, deformity, or craniofacial surgery caused by trauma or tumors. It usually leads to complex complications: skull defect syndrome, infection, hydrocephalus, hemiplegia, etc., and more likely to cause serious mental illness. [0003] Cranioplasty is usually used clinically to treat skull defects. The so-called cranioplasty is the use of surgical methods to fill the defect with biomaterials to support and protect the internal tissues. There are many types of biomaterials used. Considering the particularity of the skull shape requirements, natural bone materials such as autologous bone or allogeneic bone are insufficient...

Claims

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Application Information

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IPC IPC(8): A61F2/28A61L27/18A61L27/24A61L27/50A61L27/56A61L27/58
CPCA61F2/2875A61F2002/2835A61F2002/3093A61L27/18A61L27/24A61L27/50A61L27/56A61L27/58A61L2430/02C08L67/04
Inventor 王硕杨永栋王秀梅仇志烨宋天喜崔福斋
Owner TSINGHUA UNIV
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