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Preparation method of titanium alloy material with good biocompatibility and antibacterial function coating

A biocompatibility, titanium alloy technology, applied in the direction of coating, metal material coating process, tissue regeneration, etc., can solve the problems of low deposition efficiency, lattice displacement, infection, etc., to achieve good biocompatibility, coating The effect of uniform layer and good crystallization performance

Inactive Publication Date: 2019-08-13
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, various methods of coating preparation have some disadvantages: for example: the coating prepared by plasma spraying method (publication number CN106540319A), because plasma spraying is a linear process and applied to the surface of a complex substrate, it is easy to cause uneven coating
The coating prepared by ion beam assisted deposition (publication number CN105903091A) not only has slow coating preparation speed and low deposition efficiency, but also collides between sputtered ions and HA, causing lattice displacement of HA crystals and defects such as vacancies, making HA The coating is amorphous
For orthopedic implants, problems such as postoperative infection and local inflammation may occur in the human body, leading to "second surgery" and causing physical and psychological harm to patients

Method used

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  • Preparation method of titanium alloy material with good biocompatibility and antibacterial function coating
  • Preparation method of titanium alloy material with good biocompatibility and antibacterial function coating
  • Preparation method of titanium alloy material with good biocompatibility and antibacterial function coating

Examples

Experimental program
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Effect test

Embodiment 1

[0029] Dissolve 7.88g of calcium nitrate tetrahydrate and 2.64g of diammonium hydrogen phosphate in 30ml and 20ml of deionized water, respectively. The sanded material was first soaked in absolute ethanol for 10 min, then soaked in 2% hydrochloric acid for 1.5 h, then ultrasonically cleaned in deionized water, and finally dried at 100 °C. Under the condition of stirring, put the titanium alloy material and the calcium source solution in 1 into a closed reaction kettle. Add the phosphorus source solution into the reaction kettle, and adjust the pH of the solution to 10, and then react in an oven at 180°C for 24 hours. After the reaction is completed, the material is taken out and ultrasonically cleaned in deionized water, and then the material is placed in a 5 g / L levofloxacin-ethanol solution for 1 h, washed in phosphate buffered saline solution for 10 min in a shaker, and then dried in an air-dried oven at 80°C for 40 minutes to remove residual solvent and obtain good bioco...

Embodiment 2

[0042]Dissolve 78.8 g of calcium nitrate tetrahydrate and 24.5 g of diammonium hydrogen phosphate in 300 ml and 200 ml of deionized water, respectively. Sandpaper-polished materials were first soaked in absolute ethanol for 15 min, then soaked in 1% hydrochloric acid for 2 h, finally put in deionized water for cleaning and ultrasonication, and finally dried at 120 °C. Under the condition of stirring, put the titanium alloy material and the calcium source solution in 1 into the reaction kettle. Add the phosphorus source solution into the reaction kettle, adjust the pH of the solution to 11, and then react in an oven at 190°C for 30 h. After the reaction is completed, the material is taken out and ultrasonically cleaned in deionized water, and then the material is placed in a 5 g / L levofloxacin-ethanol solution for 1 h, washed with phosphate buffer in a shaker for 10 min, and then dried in an air-dried oven at 80°C for 40 min to remove residual solvents and obtain a good antib...

Embodiment 3

[0045] Dissolve 100g of calcium nitrate tetrahydrate and 34.95g of diammonium hydrogen phosphate in 500ml of deionized water respectively. Sandpaper-polished materials were first soaked in absolute ethanol for 5 min, then soaked in 1% hydrochloric acid for 1 h, finally put in deionized water for cleaning and ultrasonication, and finally dried at 85 °C. Under the condition of stirring, put the titanium alloy material and the calcium source solution in 1 into the reaction kettle. Add the phosphorus source solution into the reaction kettle, and adjust the pH of the solution to 9, and then react in an oven at 160°C for 18 h. After the reaction is completed, the material is taken out and ultrasonically cleaned in deionized water, and then the material is placed in a 5 g / L levofloxacin-ethanol solution for 1 h, washed with phosphate buffer in a shaker for 10 min, and then dried in an air-dried oven at 80°C for 40 min to remove residual solvents and obtain a good antibacterial and ...

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Abstract

The invention discloses a preparation method of a titanium alloy material with good biocompatibility and an antibacterial function coating. The method comprises the steps that firstly, surface treatment is conducted, then the titanium alloy material after surface treatment and a calcium source solution are placed in a closed reaction container, and through a hydrothermal reaction, a hydroxyapatitecoating is formed on the surface of the titanium alloy material; a levofloxacin-ethyl alcohol antibiotics solution is used for bacterium inhibition treatment; washing and drying are conducted for obtaining the titanium alloy material with the good biocompatibility and the antibacterial function coating. The hydroxyapatite coating is good in biocompatibility and has a bacterium inhibition functionafter being treated through levofloxacin-ethyl alcohol, hydroxyapatite is firmly bonded to titanium alloy, no residual internal stress exists on the bonding face, the coating is uniform, high in purity, good in crystallization performance and easy to operate, and the prepared titanium alloy material with the function coating can be used as an orthopedic instrument implanted into an animal body.

Description

technical field [0001] The technical field of preparation of biomedical materials of the present invention relates to a preparation method of a titanium alloy material with a functional coating on the surface. Background technique [0002] Titanium alloys have the advantages of high temperature resistance, corrosion resistance, non-toxicity, and good biocompatibility, and are widely used in medical materials. Titanium (and its titanium alloys) have good mechanical strength and impact resistance, and can be used as implant materials for artificial joints. However, the inherent inertness of titanium alloys does not allow cell growth and lacks stimulation to bone tissue, so it is not easy to form chemical bonds with bone tissue. In this regard, we can apply biological coatings on the surface of titanium alloys to improve the osteoconductivity of titanium alloys. [0003] Hydroxyapatite (HA) has good adsorption properties, biocompatibility, bioactivity, osteoconductivity and t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/32A61L27/06A61L27/54C23C26/00
CPCA61L27/06A61L27/32A61L27/54A61L2300/232A61L2300/406A61L2420/02A61L2420/06A61L2430/02C23C26/00
Inventor 朱沛志蒋家威韩贵
Owner YANGZHOU UNIV
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