Soluble powder of crystalline valnemulin hydrochloride and application thereof

Abstract

The invention discloses soluble powder of crystalline valnemulin hydrochloride and application thereof. The soluble powder consists of valnemulin hydrochloride hydrate crystal, a flavoring agent and auxiliary materials. The soluble powder made of the crystalline valnemulin hydrochloride does not induce dampness, has good thermal stability and low production cost, has no pungent smell, does not need to be coated, has better water solubility, and is beneficial to take by drinking water for livestock and poultry groups. Meanwhile, the soluble powder medicine has good palatability, improves the compliance of livestock and poultry medicines, increases the water drinking amount and the feed intake of animals, ensures the medicine dosage of livestock and poultry, and further improves the curativeeffect of valnemulin hydrochloride in prevention and treatment of mycoplasma infection and sensitive bacterial infection diseases of livestock and poultry.

Description

Technical field [0001] The invention belongs to the technical field of veterinary medicine, and specifically relates to a soluble powder of crystalline vornemulin hydrochloride and its application. Background technique [0002] Valnemulin Hydrochloride (Valnemulin Hydrochloride), also known as Valnemulin Hydrochloride, is a new generation of pleuromutilin semi-synthetic antibiotic, which belongs to the same diterpene class with tiamulin. Vonemulin hydrochloride was first developed by Sandoz in 1984. It has the advantages of a wider antibacterial spectrum and lower toxicity. It is resistant to mycoplasma and a variety of Gram-positive bacteria, such as streptococcus, Staphylococcus aureus, Actinobacillus, etc. All have good antibacterial activity, the in vitro antibacterial effect is 10-100 times that of Tysecin, and the bioavailability is close to 100%. [0003] In 1999, Vonisiline hydrochloride was approved by the European Community for the prevention or treatment of swine dysent...

AI Technical Summary

Problems solved by technology

However, the premix is ​​only limited to mixing material administration, which limits the clinical administration of warnemulin hydrochloride, and the production cost of coating is relatively high and the process is complicated

Chinese patent CN 102416004 A discloses a self-emulsifying oral nanoemulsion preparation of venomulin hydrochloride for veterinary use and its preparation method. Although it overcomes the shortcomings of the premix, it is inconvenient to transport, store and use, and needs to be added to the components Various oils, preservatives, active agents, antioxidants, for farms, the industrial cost is high

Chinese patent CN 105534912 A discloses a highly stable soluble powder of warnemulin hydrochloride, although the stability has been improved by adding a stabilizer, but if it is to be industrialized, the production cost of adding additives is too high ; At the same time, the soluble powder is easy to fly and has a serious pungent odor during the production process, which is extremely inconvenient for production and administration, while the amorphous powder has strong hygroscopicity and is easy to agglomerate for long-term storage

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