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Zinc alloy vascular stent material having ultra-high-flexible coating layer with drug sustained-release function

A flexible coating, vascular stent technology, applied in the direction of coating, metal material coating technology, medical science, etc., can solve the problems of insufficient flexibility, hard coating cracking, failure and so on

Inactive Publication Date: 2019-08-30
SOUTHWEST UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although such coatings can improve the biomedical properties of the substrate, they have the disadvantage of insufficient flexibility
However, after the vascular stent is delivered to the designated site, it needs to be deformed and opened by the balloon to unblock the blocked blood vessel, which often leads to cracking or even failure of the hard coating.

Method used

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  • Zinc alloy vascular stent material having ultra-high-flexible coating layer with drug sustained-release function
  • Zinc alloy vascular stent material having ultra-high-flexible coating layer with drug sustained-release function
  • Zinc alloy vascular stent material having ultra-high-flexible coating layer with drug sustained-release function

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Experimental program
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Effect test

Embodiment 1

[0029] (1) Provide a Zn-(2~4 at%) Li alloy as a matrix.

[0030] (2) After the surface of the substrate is polished, cleaned and dried, it is placed in a PECVD equipment, and 5% O is mixed in Ar 2 Form Ar / O 2 The plasma surface activation pretreatment was carried out in the atmosphere, and the parameters were set as follows: voltage 10W, chamber pressure 0.5mbar, total gas flow 10sccm, and treatment time 60s.

[0031] (3) After the surface activation pretreatment of the base material is completed, 3-aminopropyltriethoxysilane (APTES) is sprayed into the reaction chamber to atomize the monomer, and it is polymerized and deposited in Ar plasma with high-density amino functional groups APTES coating, where the parameters are set as: voltage 20W, chamber pressure 1.0mbar, total air flow 20sccm, processing time 30s; such as figure 1 The XPS C1s high-resolution spectrum of the APTES coating with a high density of amino functional groups deposited on the surface of the zinc alloy b...

Embodiment 2

[0036] (1) Provide a Zn-(2~4 at%) Li alloy as a matrix.

[0037] (2) After polishing, cleaning, and drying the surface of the substrate, place it in PECVD equipment, mix 5% O2 in Ar to form Ar / O2 atmosphere, and perform plasma surface activation pretreatment. The parameters are set as: voltage 10W, chamber pressure 0.5 mbar, the total air flow is 10sccm, and the processing time is 60s.

[0038] (3) After the surface activation pretreatment of the base material is completed, (3-aminopropyl)triethoxysilane (APTES) is sprayed into the reaction chamber to atomize the monomer, and the polymerization deposition in Ar plasma has a high density APTES coating with amino functional groups, where the parameters are set as: voltage 20W, chamber pressure 1.0mbar, total gas flow 20sccm, treatment time 30s.

[0039] (4) Dissolve PLGA in dichloromethane to prepare the PLGA solution required for this experiment. The concentration of PLGA in dichloromethane is 10 mg / mL. Then fully mix 0.1%wt ...

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Abstract

The present invention discloses a zinc alloy vascular stent material having an ultra-high-flexible coating layer with a drug sustained-release function, and a preparation method thereof. The vascularstent material comprises a zinc alloy matrix, an amino-rich functional group polymerization coating layer and a drug-loaded polylactic acid-glycolic acid copolymer PLGA coating layer. The vascular stent material is made of zinc alloy as the matrix, has the ultra-high-flexible coating layer with the drug sustained-release function, and is prepared by a plasma enhanced chemical vapor deposition (PECVD) technology and a spin-applying and membranecoating technology. The preparation method comprises the following steps: the PECVD method is used to polymerize and deposit an amino-rich functional group 3-aminopropyltriethoxysilane APTES coating layer on a surface of the Zn-(2-4 at%) Li matrix material; at the same time, dichloromethane is added into a target medicine, biochemical active factors and PLGA, and the materials are mixed evenly, then the spin-applying technology is used to apply and coat the mixture on the surface of the zinc alloy matrix deposited with the APTES, and drying and sterilizing are conducted to obtain the vascular stent material.

Description

technical field [0001] The invention relates to a zinc alloy vascular stent material with a drug slow-release function and an ultra-high flexible coating, in particular to a zinc alloy as a substrate, the surface of which is covered with high-density amino functional groups polymerized and deposited by PECVD technology. The APTES coating and the drug / biochemical active factor / PLGA drug slow-release layer grafted on it by spin-coating technology have beneficial effects such as spontaneous degradation, promoting vascular endothelialization, and preventing restenosis, and belong to the field of cardiovascular implant materials. Background technique [0002] Cardiovascular and cerebrovascular diseases such as coronary heart disease, myocardial infarction, and cerebral infarction caused by atherosclerosis are hot issues that urgently need to be solved in clinical medicine. Based on the concept of endovascular interventional therapy, medical workers have proposed a method of impla...

Claims

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Application Information

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IPC IPC(8): A61L31/14A61L31/02A61L31/10A61L31/16C23C16/50
CPCA61L31/022A61L31/10A61L31/14A61L31/148A61L31/16A61L2300/102A61L2300/41A61L2300/414A61L2300/416A61L2300/42A61L2300/43A61L2300/45A61L2300/602C23C16/50C08L67/04C08L89/00C08L83/08
Inventor 饶席胡豪侣杨济涵张永平
Owner SOUTHWEST UNIVERSITY
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