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Preparation method and application of pH-responsive hydrogel

A hydrogel and responsive technology, applied in the field of preparation of pH-responsive hydrogels, can solve the problems of premature degradation of substances, affecting utilization rate, etc., so as to alleviate intestinal damage, reduce losses, and achieve good pH responsiveness. Effect

Active Publication Date: 2019-09-03
ANHUI UNIVERSITY OF TECHNOLOGY AND SCIENCE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002]Some biologically active agents such as proteins, nucleic acids, enzymes, etc., lead to premature degradation of substances due to oral administration, thus affecting the utilization rate

Method used

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  • Preparation method and application of pH-responsive hydrogel
  • Preparation method and application of pH-responsive hydrogel
  • Preparation method and application of pH-responsive hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A preparation method of CS / SA / γ-PGApH responsive hydrogel, comprising the following steps:

[0034] (1) Dissolve 0.04g of γ-polyglutamic acid in 15mL of sodium hydroxide solution with a pH of 9.0, then add 0.36g of chitosan to mix, and stir evenly at 45°C and 800rpm to obtain a mixed solution A;

[0035] (2) Add a 3% sodium alginate solution with an equal volume to the mixed solution A, and stir evenly to obtain the mixed solution B;

[0036] (3) Add 2 mL of glacial acetic acid solution of 4% volume concentration dropwise at a rate of 50 μL / min into the mixed solution B, and stir for 1 hour to obtain a reaction solution C;

[0037] (4) Add the reaction solution C dropwise to 50mL of 2% calcium chloride solution at a rate of 3mL / min. After curing for 0.5h, wash with distilled water to obtain the pH response of CS / SA / γ-PGA type hydrogel. Its optical microscope image is figure 1 , 2 As shown, it can be seen from the figure that the CS / SA / γ-PGA pH-responsive hydrogel pr...

Embodiment 2

[0041] A preparation method of a pH-responsive hydrogel, the others are the same as in Example 1, except that in step (3), the volume of the glacial acetic acid solution is 1mL, and the obtained hydrogel microspheres have the same good properties as in Example 1 after testing. pH responsiveness.

Embodiment 3

[0043] A preparation method of a pH-responsive hydrogel, the others are the same as in Example 1, except that in step (2), the mass concentration of the sodium alginate solution is 5%, and the obtained hydrogel microspheres are the same as in Example 1 after testing Has good pH responsiveness.

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Abstract

The invention discloses a preparation method and application of a pH-responsive hydrogel. The preparation method of the pH-responsive hydrogel includes the following steps: dissolving gamma-polyglutamic acid in an alkali solution, then adding chitosan, and mixing evenly to obtain a mixed solution A; adding a sodium alginate solution with equal volume to the mixed solution into the mixed solution,and stirring evenly, to obtain a mixed solution B; dropwise adding a glacial acetic acid solution into the mixed solution B, and carrying out stirring reaction to obtain a reaction liquid C; and dropwise adding the reaction liquid C into a calcium chloride solution, carrying out curing reaction, and cleaning to obtain the pH-responsive hydrogel. The prepared hydrogel has good pH responsiveness, and the used substrate has good biocompatibility, no toxic or side effects and no irritation. The preparation process is simple and easy to implement, does not use toxic and side-effect organic solvents, catalysts or initiators, and does not need emulsifiers. Therefore, the preparation process is safe, green and pollution-free, and suitable for industrialized production.

Description

technical field [0001] The invention belongs to the technical field of biological materials, and in particular relates to a preparation method and application of a pH-responsive hydrogel. Background technique [0002] Some bioactive agents, such as proteins, nucleic acids, enzymes, etc., lead to premature degradation of substances due to oral administration, thus affecting the utilization rate. The main reason is that most of the biological activities of these biological agents or biological products will be destroyed when they pass through the extremely acidic environment of the stomach, and the active ingredients that reach the main absorption site are greatly reduced, and at the same time, the high concentration of drugs or biological products are directly released to the stomach Intestinal mucosa can be damaged. Therefore, designing an environment-responsive drug release system, constructing an intelligent carrier, and realizing targeted drug release have become researc...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/34A61K47/36
CPCA61K9/06A61K47/34A61K47/36Y02A50/30
Inventor 聂光军岳文瑾王倩洪康进刘宁
Owner ANHUI UNIVERSITY OF TECHNOLOGY AND SCIENCE