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Nano fiber membrane of dual-loading nucleus/shell structure and preparation method of nano fiber membrane

A nanofiber membrane, dual-loading technology, applied in fiber processing, fiber chemical characteristics, rayon manufacturing, etc., can solve the problems of low effective dose and low absorption rate, and achieve increased persistence, low cytotoxicity, and excellent biological phase. Capacitive and Biodegradable Effects

Active Publication Date: 2019-09-03
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the oral absorption rate of simvastatin is low, and the effective dose reaching the local periodontal tissue is small. The preparation of sustained-release drug can effectively improve the bioavailability of the drug in local tissues.

Method used

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  • Nano fiber membrane of dual-loading nucleus/shell structure and preparation method of nano fiber membrane
  • Nano fiber membrane of dual-loading nucleus/shell structure and preparation method of nano fiber membrane
  • Nano fiber membrane of dual-loading nucleus/shell structure and preparation method of nano fiber membrane

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Effect test

Embodiment 1

[0042] The preferred embodiment of the present invention provides a dual-loaded core / shell structured nanofiber membrane. The specific preparation method is as follows:

[0043] Weigh chitosan (CS) and polyoxyethylene (PEO) with a mass ratio of 8:2, where PEO is used as a fiber-forming aid, and weigh the nano-hydroxyapatite with a mass of 1 / 9 of the total mass of CS and PEO Stone (nHA), stir with trifluoroacetic acid as a solvent until it is completely dissolved, configure it into a shell spinning solution with a solute weight to solvent volume ratio of 4g:100mL; then weigh a polycaprolactone with a mass ratio of 9:1 ( PCL) and simvastatin, stirred with trifluoroethanol as a solvent until completely dissolved, and configured into a nuclear layer spinning solution with a solute weight to solvent volume ratio of 13g:100mL;

[0044] Inject the shell spinning solution into the outer 5mL syringe, and the core spinning solution into the inner 5mL syringe. Use a coaxial spinning nozzle (t...

Embodiment 2

[0046] The preferred embodiment of the present invention provides a dual-loaded core / shell structured nanofiber membrane. The specific preparation method is as follows:

[0047] Weigh chitosan (CS) and polyoxyethylene (PEO) with a mass ratio of 8:2, where PEO is used as a fiber-forming aid, and weigh the nano-hydroxyapatite with a mass of 1 / 9 of the total mass of CS and PEO Stone (nHA), stir with trifluoroacetic acid as a solvent until it is completely dissolved, configure it into a shell spinning solution with a solute weight to solvent volume ratio of 4g:100mL; then weigh a polycaprolactone with a mass ratio of 9:1 ( PCL) and simvastatin, mixed with dichloromethane as a solvent until completely dissolved, and configured into a nuclear layer spinning solution with a solute weight to solvent volume ratio of 13g:100mL;

[0048] Inject the shell spinning solution into the outer 5mL syringe, and the core spinning solution into the inner 5mL syringe. Use a coaxial spinning nozzle (the ...

Embodiment 3

[0050] The preferred embodiment of the present invention provides a dual-loaded core / shell structured nanofiber membrane. The specific preparation method is as follows:

[0051] Weigh chitosan (CS) and polyoxyethylene (PEO) with a mass ratio of 7:3, where PEO is used as a fiber-forming aid, and weigh the nano-hydroxyapatite with a mass of 1 / 9 of the total mass of CS and PEO Stone (nHA), stir with trifluoroacetic acid as a solvent until it is completely dissolved, configure it into a shell spinning solution with a solute weight to solvent volume ratio of 4g:100mL; then weigh a polycaprolactone with a mass ratio of 9:1 ( PCL) and simvastatin, stirred with trifluoroethanol as a solvent until completely dissolved, and configured into a nuclear layer spinning solution with a solute weight to solvent volume ratio of 13g:100mL;

[0052] Inject the shell spinning solution into the outer 5mL syringe, and the core spinning solution into the inner 5mL syringe. Use a coaxial spinning nozzle (t...

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Abstract

The invention discloses a nano fiber membrane of a dual-loading nucleus / shell structure and a preparation method of the nano fiber membrane. According to the nano fiber membrane, a polymer with good mechanical properties is used as a nucleus layer material, a polymer with good biocompatibility and a composite material of the polymer and calcium phosphate salt are used as a shell layer material, through a coaxial electrostatic spinning method, the nano fiber membrane of the nucleus / shell structure is prepared, simvastatin is added to a nucleus layer, and the simvastatin-loading nano fiber membrane of the nucleus / shell structure is prepared. The prepared nano fiber membrane of the dual-loading nucleus / shell structure is used as a guided tissue regeneration membrane and has the advantages that the medicine loading amount is controllable, slow release of medicine can be controlled, and osteogenesis and blood vessel generation are promoted.

Description

Technical field [0001] The invention belongs to the technical field of nanofiber membranes, and specifically relates to a dual-loaded core / shell structured nanofiber membrane and a preparation method thereof. Background technique [0002] Periodontal disease is a common oral disease. Periodontitis is the most common type of periodontal disease. It is also an important reason for the destruction of periodontal tissues and tooth loss. At present, guided tissue regeneration in the treatment of periodontitis has been widely used because of its low cost and good effect. Guided tissue regeneration membrane is the key to the success of periodontal guided tissue regeneration. Guided tissue regeneration membranes are divided into degradable membranes and non-degradable membranes. The degradable membranes are degradable in the body and avoid the secondary surgery to the patient. It is painful and economical and has huge potential for clinical application. The excellent guided tissue rege...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/4382D04H1/728D01D5/00A61L27/12A61L27/18A61L27/20A61L27/54A61L27/58D01F1/10D01F8/14D01F8/16D01F8/18
CPCA61L27/12A61L27/18A61L27/20A61L27/54A61L27/58A61L2300/206A61L2300/216A61L2300/412A61L2300/414A61L2300/604D01D5/003D01D5/0061D01D5/0092D01F1/10D01F8/14D01F8/16D01F8/18D04H1/4382D04H1/728C08L5/08C08L67/04C08L71/02
Inventor 李玉宝邓丹李吉东黄金会左奕邹琴张利
Owner SICHUAN UNIV
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