One-step synthesis of spherical hollow mesoporous bismuth sulfide/silica nanomaterials

A technology of hollow mesoporous and nanomaterials, applied in the direction of silica, silicon oxide, nanotechnology, etc., can solve the problems of restricting in-depth research and clinical transformation, difficult large-scale production, complex preparation process, etc., to achieve the compensation of grain structure Difficult to regulate, easy to synthesize, and expand the scope of application

Active Publication Date: 2022-02-08
SHANXI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, the construction of hollow mesoporous silica nanoparticles mostly adopts a step-by-step synthesis method, the preparation process is complicated, there are many variable factors, and it is not easy to scale production, which greatly limits its in-depth research and clinical transformation.

Method used

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  • One-step synthesis of spherical hollow mesoporous bismuth sulfide/silica nanomaterials
  • One-step synthesis of spherical hollow mesoporous bismuth sulfide/silica nanomaterials
  • One-step synthesis of spherical hollow mesoporous bismuth sulfide/silica nanomaterials

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Take 138.6mL of nitric acid with a concentration of 65% and 806mL of deionized water, add them into a beaker and mix them thoroughly, move the mixed solution to a volumetric flask, and prepare a nitric acid solution with a concentration of 2moL / L for later use;

[0030] Take 83.33g of sodium hydroxide and 1L of deionized water, add them into a beaker and mix them thoroughly, transfer the mixed solution to a volumetric flask, and prepare a sodium hydroxide solution with a concentration of 2moL / L for later use;

[0031] Take 120mL of deionized water, 3.750g of bovine serum albumin, and 1.05g of cetyltrimethylammonium bromide, add them together into a beaker, stir at 30°C for 10min, and form a transparent solution; take 0.36g of bismuth nitrate pentahydrate and dissolve it in 15mL2moL / L of nitric acid solution, add it to the mixed solution, put it in an ultrasonic disperser for dissolution and dispersion, the frequency is 59KHz, and the dispersion time is 10min; use the pr...

Embodiment 2

[0040] Take 138.6mL of nitric acid with a concentration of 65% and 806mL of deionized water, add them into a beaker and mix them thoroughly, move the mixed solution to a volumetric flask, and prepare a nitric acid solution with a concentration of 2moL / L for later use;

[0041] Take 83.33g of sodium hydroxide and 1L of deionized water, add them into a beaker and mix them thoroughly, transfer the mixed liquid to a volumetric flask, and prepare a sodium hydroxide solution with a concentration of 2moL / L for later use;

[0042] Take 75mL of deionized water, 2.250g of bovine serum albumin, and 0.45g of cetyltrimethylammonium bromide, add them together into a beaker, stir at 30°C for 5min, and form a transparent solution; take 0.18g of bismuth nitrate pentahydrate and dissolve it in 12mL2moL / L of nitric acid solution, add it to the mixed solution, place it in an ultrasonic disperser for dissolution and dispersion, the frequency is 59KHz, and the dispersion time is 10min; use the pre-...

Embodiment 3

[0046] Take 138.6mL of nitric acid with a concentration of 65% and 806mL of deionized water, add them into a beaker and mix them thoroughly, move the mixed solution to a volumetric flask, and prepare a nitric acid solution with a concentration of 2moL / L for later use;

[0047] Take 83.33g of sodium hydroxide and 1L of deionized water, add them into a beaker and mix them thoroughly, transfer the mixed solution to a volumetric flask, and prepare a sodium hydroxide solution with a concentration of 2moL / L for later use;

[0048] Take 150mL of deionized water, 6.000g of bovine serum albumin, and 1.80g of cetyltrimethylammonium bromide, add them together into a beaker, stir at 30°C for 15min, and form a transparent solution; take 1.44g of bismuth nitrate pentahydrate and dissolve it in 18mL2moL / L of nitric acid solution, add it to the mixed solution, place it in an ultrasonic disperser for dissolution and dispersion, the frequency is 59KHz, and the dispersion time is 10min; use the ...

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Abstract

The invention relates to the technical field of preparation of hollow nano-biological materials, and more specifically relates to a one-step synthesis method of spherical hollow mesoporous bismuth sulfide / silicon dioxide nano-materials. Using orthosilicate, surfactant, albumin, inorganic bismuth source, dilute nitric acid, sodium hydroxide, ammonium nitrate, and absolute ethanol as raw materials, through constant temperature crystallization, template removal, and centrifugation, hollow mesoporous Bi 2 S 3 / SiO 2 nanomaterials to greatly increase the Bi 2 S 3 / SiO 2 The purity of nanomaterials, the expansion of Bi 2 S 3 / SiO 2 Applications of nanomaterials. This process is a rapid and controllable synthesis of hollow mesoporous Bi 2 S 3 / SiO 2 The process of nanomaterials can realize the synthesis of hollow mesoporous Bi by changing the addition amount of surfactant, tetraethyl silicate and albumin 2 S 3 / SiO 2 The controllable adjustment of the particle size of the microsphere and the thickness of the hollow layer of the nanomaterial. Hollow mesoporous Bi prepared by the inventive method 2 S 3 / SiO 2 The properties of the nanometer material are as follows: the particle diameter is 80-150nm, the thickness of the hollow outer layer is 10-20nm, and the product purity reaches 99.9%.

Description

technical field [0001] The invention relates to the technical field of preparation of hollow nano-biological materials, and more specifically relates to a one-step synthesis method of spherical hollow mesoporous bismuth sulfide / silicon dioxide nano-materials. Background technique [0002] Cancer is currently one of the major diseases that precision medicine mainly tackles. Molecular imaging technology is used to conduct early diagnosis and boundary precision of tumors, and construct personalized treatment, in order to achieve efficient and precise diagnosis and treatment of cancer with low side effects. With the rise of nanotechnology, using the characteristics of nanomaterials to expand the application field of molecular imaging technology and realize the application of nanomaterials in disease treatment is not only of great significance to molecular imaging technology, but also provides a new era for the development of new cancer treatment methods. [0003] At present, a v...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01G29/00C01B33/12B82Y40/00B82Y30/00
CPCC01G29/00C01B33/12B82Y40/00B82Y30/00C01P2004/34C01P2002/72C01P2004/04C01P2006/17C01P2002/85C01P2006/80
Inventor 郑子良张瑞平贾卓赵振祥谢鲜梅
Owner SHANXI MEDICAL UNIV
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