Unlock instant, AI-driven research and patent intelligence for your innovation.

Freeze-dried powder with whitening activity and preparation method and application thereof

A freeze-dried powder and active technology, applied in the field of freeze-dried powder with whitening activity and its preparation, can solve the problems of increased stimulation source, easy discoloration, limited use concentration, etc. Highly active effect

Active Publication Date: 2022-03-08
珠海美逸生物科技有限公司
View PDF8 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

1. Antioxidant whitening active substances mainly include vitamin C, vitamin E and their derivatives. The disadvantage is that they are easily oxidized and inactivated and have a certain degree of irritation. They are easy to change color when added to the product, thus limiting their use; 2. 1. Substances that inhibit tyrosinase activity mainly include tranexamic acid, arbutin, kojic acid, and small molecule active peptides, which also have problems such as irritation and discoloration; 3. Substances that accelerate the metabolism of the stratum corneum to achieve whitening effects mainly include Fruit acid, salicylic acid, etc., but the concentration of these substances is strictly limited, and people with sensitive skin should use them with caution
[0004] At present, the main dosage forms of whitening cosmetics are concentrated in products such as essence water, cream and facial mask. The formula ingredients of these products are relatively complex, and many whitening active substances are less stable after dissolution. In addition, some preservatives will also increase irritation. source, thereby affecting the effect of the final product

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Freeze-dried powder with whitening activity and preparation method and application thereof
  • Freeze-dried powder with whitening activity and preparation method and application thereof
  • Freeze-dried powder with whitening activity and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The preparation of embodiment 1 experimental group sample

[0043] 1. Preparation of whitening lyophilized powder

[0044] The formula of each component of the whitening freeze-dried powder is shown in Table 1. Weigh deionized water, tranexamic acid, nicotinamide, mannitol, and ascorbyl glucoside according to the weight ratio. Bottles are filled, and then placed in a vacuum dryer. The vacuum freeze-drying parameters are as follows: first place at -45°C, pre-freeze for 2h; gradient temperature method for one drying, -20°C, 3h; -5°C, 5h; then Carry out secondary drying, quickly raise the temperature to 30°C for 3h, then quickly enter the ultimate vacuum state, and keep at 30°C for 4h.

[0045] Table 1. Formula table of whitening freeze-dried powder

[0046]

[0047] 2. Preparation of whitening freeze-dried powder vehicle

[0048] The formula of the whitening freeze-dried powder solvent is shown in Table 2. After the solvent is prepared, it will be filled in 2.5 mL a...

Embodiment 2

[0052] The preparation of embodiment 2 control group sample

[0053] 1. Preparation of Whitening Essence

[0054] The whitening essence formula is shown in Table 3. According to the increasing dosage of tranexamic acid, niacinamide, and ascorbyl glucoside, three gradient samples were made, and deionized water, glycerin, and sodium hyaluronate were dispersed at 85°C according to the weight ratio. After cooling down to room temperature evenly, add tranexamic acid, nicotinamide, ascorbyl glucoside, propylene glycol, bis(hydroxymethyl)imidazolidinyl urea, and iodopropynyl butyl carbamate and stir to dissolve completely.

[0055] Table 3. Preparation of whitening essence

[0056]

[0057] 2. Preparation of Whitening and Moisturizing Cream

[0058] The formula of whitening and moisturizing cream is shown in Table 4. According to the increase of the dosage of tranexamic acid, niacinamide, and ascorbyl glucoside, three gradient samples were made, and deionized water, glycerin, hy...

Embodiment 3

[0062] The stability test comparison of embodiment 3 experimental group and control group

[0063] 1. The results of formula screening and evaluation of the experimental group are shown in Table 5. Selecting a suitable filler ratio makes the preparation easy to freeze-dry and maintain a good appearance and mechanical strength.

[0064] Table 5. Formula screening table of experimental group

[0065]

[0066] It can be seen from Table 5 that formula 4 has the best molding effect and the best mechanical strength after selecting the ratio of formula 4 based on various technical indicators. Therefore, formula 4 was selected as the experimental group of whitening freeze-dried powder.

[0067] 2. Stability test comparison such as Table 6 and figure 1 . The ratio of the active whitening ingredients in formula A of the whitening essence and moisturizing cream of the control group was designed according to the ratio of the active whitening ingredients acting on the test body after ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a freeze-dried powder with whitening activity, its preparation method and application. The freeze-dried powder is composed of tranexamic acid, nicotinamide, mannitol sugar and ascorbyl glucoside, which can effectively dilute melanin, and can brighten and whiten the skin after long-term use. It does not add chemical preservatives, does not stimulate the skin, and is stable and does not change color. , The product is highly active, safe and effective. The invention also provides the preparation method of the freeze-dried powder, which can effectively shorten the freeze-drying time, save energy and protect the environment, reduce the production cost, and obtain a freeze-dried powder with good forming effect, firm appearance, fast redissolving speed and good solution clarity. dry powder product. Simultaneously, described freeze-dried powder also can be directly added in the cosmetics of other liquid formulations, such as essence liquid, moisturizing water for dissolving and using, also can be mixed with solvent after adding in the cosmetics of solid dosage forms, such as moisturizing cream and stir evenly for use, In order to enhance the effect, it provides a new development idea for the development of whitening products.

Description

technical field [0001] The invention belongs to the field of cosmetics, in particular to a freeze-dried powder with whitening activity and its preparation method and application. Background technique [0002] With the development of the economy and the improvement of people's living standards, people pay more and more attention to the whitening of the skin, especially Asian women pay more attention to the whitening of the skin, and require the research of more natural, safer and milder whitening agents, which also makes Whitening products are developing rapidly. [0003] According to the whitening mechanism, the current whitening active substances are mainly divided into three categories. 1. Antioxidant whitening active substances mainly include vitamin C, vitamin E and their derivatives. The disadvantage is that they are easily oxidized and inactivated and have a certain degree of irritation. They are easy to change color when added to the product, thus limiting their use;...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/67A61K8/44A61K8/34A61K8/02A61Q19/00A61Q19/02
CPCA61K8/676A61K8/675A61K8/44A61K8/345A61K8/022A61Q19/00A61Q19/02A61K2800/84
Inventor 蔡敬贤熊盛陈红英陈伟邓小英王丹丹
Owner 珠海美逸生物科技有限公司