Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Barium titanate and graphene oxide synergistically enhanced poly-L-lactic acid composite material and preparation method thereof

A technology of L-polylactic acid and composite materials, which is applied in the field of L-lactic acid composite materials and its preparation, can solve the problems of insufficient mechanical strength, poor hydrophilicity, and low cell activity, and achieve the effect of enhancing mechanical properties and promoting uniform dispersion

Active Publication Date: 2019-09-27
JIANGXI UNIV OF SCI & TECH +1
View PDF7 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the problems of insufficient mechanical strength, low cell activity and poor hydrophilicity in PLLA used as a bone graft material in the prior art, the purpose of the present invention is to provide a L-polylactic acid composite material synergistically reinforced by barium titanate and graphene oxide and its preparation method, the larger surface area of ​​GO in the composite material can be nano BaTiO 3 The uniform deposition on its surface provides active sites and supports, while the nano-BaTiO intercalated between the GO layers 3 It can play a supporting role, thereby promoting the BaTiO 3 The uniform dispersion of GO and GO in the PLLA matrix enhances the mechanical properties of PLLA; on the other hand, GO has excellent electrical conductivity, and as conductive particles, it can effectively increase the dielectric constant of the scaffold, thereby promoting the BaTiO 3 The deflection of the dipole in the middle enhances the piezoelectric properties of the scaffold and promotes the proliferation and differentiation of osteoblasts under the action of electrical stimulation, so that the composite scaffold has good biological activity.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Barium titanate and graphene oxide synergistically enhanced poly-L-lactic acid composite material and preparation method thereof
  • Barium titanate and graphene oxide synergistically enhanced poly-L-lactic acid composite material and preparation method thereof
  • Barium titanate and graphene oxide synergistically enhanced poly-L-lactic acid composite material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) Weigh 0.2g of GO powder with an electronic balance, with a particle size of 5-15μm, add it to a beaker containing 30mL of absolute ethanol solution, and obtain a uniform and stable GO suspension under mechanical stirring and ultrasound. .

[0035] (2) Weigh 10g of BaTiO with an electronic balance 3 Powder, with a particle size of 0.1~1μm, added to a beaker containing 50mL of anhydrous ethanol solution, under the action of mechanical stirring and ultrasound, uniform and stable BaTiO 3 suspension.

[0036] (3) Use an electronic balance to weigh 89.8g of PLLA powder with a particle size of 60μm and a melting point of 180°C. Add it to a beaker containing 250mL of absolute ethanol solution. Under mechanical stirring and ultrasound, a uniform and stable PLLA suspension; then slowly add PLLA suspension to BaTiO 3 In the mixed suspension with GO, the mixed solution is uniformly mixed by mechanical stirring and ultrasonic dispersion. The mechanical stirring time is 100min, the ro...

Embodiment 2

[0042] (1) Weigh 0.1g of GO powder with an electronic balance, with a particle size of 5-15μm, add it to a beaker containing 30mL of absolute ethanol solution, and obtain a uniform and stable GO suspension under the action of mechanical stirring and ultrasound .

[0043] (2) Weigh 10g of BaTiO with an electronic balance 3 Powder, with a particle size of 0.1~1μm, added to a beaker containing 50mL of anhydrous ethanol solution, under the action of mechanical stirring and ultrasound, uniform and stable BaTiO 3 suspension.

[0044] (3) Use an electronic balance to weigh 89.9g of PLLA powder with a particle size of 60μm and a melting point of 180°C. Add it to a beaker containing 250mL of absolute ethanol solution. Under mechanical stirring and ultrasound, a uniform and stable PLLA suspension; then slowly add PLLA suspension to BaTiO 3 Mix the mixture with GO in the suspension, and then mix the mixed solution uniformly by magnetic stirring and ultrasonic dispersion. The time of mechanica...

Embodiment 3

[0050] (1) Use an electronic balance to weigh 0.3g of GO powder with a particle size of 5-15μm, add it to a beaker containing 30mL of absolute ethanol solution, and obtain a uniform and stable GO suspension under mechanical stirring and ultrasound. .

[0051] (2) Weigh 10g of BaTiO with an electronic balance 3 Powder, with a particle size of 0.1~1μm, added to a beaker containing 50mL of anhydrous ethanol solution, under the action of mechanical stirring and ultrasound, uniform and stable BaTiO 3 suspension.

[0052] (3) Use an electronic balance to weigh 89.7g of PLLA powder with a particle size of 60μm and a melting point of 180°C. Add it to a beaker containing 250mL of absolute ethanol solution. Under mechanical stirring and ultrasound, a uniform and stable PLLA suspension; then slowly add PLLA suspension to BaTiO 3 Mix the mixture with GO in the suspension, and then mix the mixed solution uniformly by magnetic stirring and ultrasonic dispersion. The time of mechanical stirring a...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Ultimate tensile strengthaaaaaaaaaa
Piezoelectric constantaaaaaaaaaa
Particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention discloses a barium titanate and graphene oxide synergistically enhanced poly-L-lactic acid composite material. The barium titanate and graphene oxide synergistically enhanced poly-L-lactic acid composite material comprises the following components in percentages by mass: 80-90wt% of PLLA, 9.5-19.9wt% of BaTiO3 and 0.1-0.5wt% of GO. GO in the composite material can provide an active site and a carrier for adhesion deposition of nano BaTiO3 on the surface of the composite material, and the nano BaTiO3 sandwiched between GO layers can support the nano BaTiO3, so that uniform dispersion of BaTiO3 and GO in a PLLA matrix is promoted, and the mechanical property of PLLA is enhanced; and on the other hand, GO has excellent conductive performance, and as conductive particles, Go can effectively increase the dielectric constant of a stent, so that deflection of dipoles in BaTiO3 is promoted, piezoelectric performance of the stent is further enhanced, proliferation and differentiation of osteoblasts are promoted under the action of electrical stimulation, and the composite stent has good biological activity.

Description

Technical field [0001] The invention belongs to the technical field of biological materials, and in particular relates to a L-polylactic acid composite material enhanced by barium titanate and graphene oxide synergistically and a preparation method thereof. Background technique [0002] Artificial bone has received widespread attention from domestic and foreign researchers because of its ability to effectively relieve the limited amount of bone in autologous or allogeneic bone, the prone to immune response when implanted in the body, and the difficulty of personalized manufacturing. Because polymer materials have good biological properties, they are widely used in artificial implant materials. Among them, poly(L-lactic acid) (PLLA) has good biocompatibility and biodegradability, and has been approved by the US Food and Drug Administration. The Administration (FDA) approved for implant materials. However, the use of PLLA as a bone graft material has problems such as insufficient ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/50A61L27/18A61L27/02
CPCA61L27/50A61L27/18A61L27/025A61L2430/02C08L67/04
Inventor 杨友文帅词俊戚方伟彭淑平杨文静
Owner JIANGXI UNIV OF SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com