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A kind of core-shell type nano-gold composite material and its preparation method and application

A composite material and nano-gold technology, which is applied in the field of core-shell nano-gold composite materials and preparation, can solve problems such as poor stability and poor biocompatibility, and achieve the effects of large loading, simple preparation method and wide application range.

Active Publication Date: 2021-10-26
TAIYUAN UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In order to solve the deficiencies in the prior art, the invention discloses a core-shell nano-gold composite material and its preparation method and application. The material improves the photothermal performance of gold nanorods and solves the problem of poor biocompatibility , poor stability, and the gold nanorod carrier has fluorescence characteristics, which has good application potential in photothermal therapy and bioimaging

Method used

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  • A kind of core-shell type nano-gold composite material and its preparation method and application
  • A kind of core-shell type nano-gold composite material and its preparation method and application
  • A kind of core-shell type nano-gold composite material and its preparation method and application

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preparation example Construction

[0046] A preparation method of a core-shell type nano-gold composite material, comprising the steps of:

[0047] 1) Preparation of gold nanorod solution (AuNRs) by seed-free method:

[0048]Dissolve CTAB in ultrapure water, add chloroauric acid solution, silver nitrate solution, ascorbic acid solution, and sodium borohydride solution in sequence, then stir for 10-30s in a water bath at 30-40 degrees, and let it stand for 4-8 hours. Centrifuge at a speed of more than 10,000 rpm, remove the supernatant to obtain the lower colloidal solution, wash with deionized water, remove excess CTAB solution, and remove the lower colloidal solution to obtain the gold nanorod solution;

[0049] The molar ratio of each reaction component is CTAB: chloroauric acid: silver nitrate: ascorbic acid: sodium borohydride=80000:40-50:100-150:500-600:1-2.

[0050] Preferably, the molar ratio of each reaction component is CTAB: chloroauric acid: silver nitrate: ascorbic acid: sodium borohydride = 80000:...

Embodiment 1

[0076] 1) Preparation of gold nanorod solution (AuNRs) by seed-free method:

[0077] Synthesize gold nanorods by seedless method, first weigh 1.8218g CTAB powder and dissolve it in 50ml ultrapure water, and dissolve it by ultrasonic;

[0078] Take the dissolved CTAB 10ml 0.1M and put it into the Erlenmeyer flask, add 208ul 0.024M chloroauric acid solution, 100ul 0.01M silver nitrate solution, 60ul 0.1M ascorbic acid solution successively under stirring in a 37 degree water bath. Then add 16ul 1mM sodium borohydride solution and stir for 25s. After the solution was allowed to stand for 6 hours, it was centrifuged with ultrapure water to remove excess CTAB to obtain a gold nanorod solution.

[0079] The sodium borohydride solution is prepared from ice water.

[0080] 2) Preparation of gold nanorods wrapped in mesoporous silica,

[0081] After the prepared gold nanorods were sonicated for 15 minutes, 10ml was added to the Erlenmeyer flask, stirred in a 30-degree water bath, an...

Embodiment 2

[0101] 1) Preparation of gold nanorod solution

[0102] Using the seedless method to synthesize gold nanorods, first weigh 1.8218g CTAB powder and dissolve it in 50ml ultrapure water, and dissolve it by ultrasonic; take the dissolved CTAB 10ml 0.1M and add it to the Erlenmeyer flask, then add 208ul 0.024 M of chloroauric acid solution, 100ul of 0.01M silver nitrate solution, 60ul of 0.1M ascorbic acid solution. Then add 16ul 1mM sodium borohydride solution (prepared with ice water), and stir for 25s. After the solution was allowed to stand for 6 hours, it was centrifuged with ultrapure water to remove excess CTAB to obtain a gold nanorod solution.

[0103] 2) Preparation of gold nanorods wrapped in mesoporous silica, after ultrasonication of the prepared gold nanorods for 15 minutes, take 10ml into the Erlenmeyer flask, stir in a 30-degree water bath and add 100ul 0.1M NaOH to react for 30min, then add in three times 40ul TEOS (20% methanol), with an interval of 30min each t...

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Abstract

The invention provides a core-shell nano-gold composite material and its preparation method and application. The preparation method comprises the following steps: mixing CTAB, chloroauric acid solution, silver nitrate solution, ascorbic acid solution and sodium borohydride solution to obtain gold nano Rod solution; After ultrasonicating the gold nanorod solution, add TEOS methanol solution dropwise and react to make a mesoporous silica gold nanorod solution; add APTES methanol solution for amination reaction to obtain aminated mesoporous silica A silicon-gold nanorod solution; adding the gold nanocluster solution into the aminated mesoporous silicon dioxide gold nanorod solution for reaction to obtain a core-shell nano-gold composite material. The material improves the photothermal performance of gold nanorods, and makes the gold nanorod carrier have fluorescence characteristics, and has good application potential in photothermal therapy and biological imaging. The preparation method solves the problems of poor biocompatibility and poor stability of the gold nanorod.

Description

technical field [0001] The invention discloses a core-shell nano-gold composite material, a preparation method and an application thereof, and belongs to the technical field of nanometer materials and special materials. Background technique [0002] Gold nanorods have attracted extensive attention due to their unique physicochemical properties and their potential biophotonics applications, such as photothermal therapy, biosensing, molecular imaging, etc. Like spherical gold nanoparticles, gold nanorods themselves have specific surface plasmon resonance properties. By controlling their aspect ratio, longitudinal surface plasmon resonance properties from the visible to the near-infrared range can be obtained. In addition, the LP of gold nanorods is tunable in the near-infrared region. When irradiated by a near-infrared light source, the gold nanorods will quickly become a highly concentrated local heat source due to the plasmon resonance characteristics, and the heat generat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F9/24B82Y40/00B82Y30/00B22F1/02B22F1/00A61K49/00A61K47/02A61K41/00A61P35/00
CPCB22F9/24B82Y40/00B82Y30/00A61K49/0019A61K47/02A61K41/0052A61P35/00B22F1/145B22F1/16
Inventor 段倩倩杨敏桑胜波张强张博叶王晓圆
Owner TAIYUAN UNIV OF TECH
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