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Injection filling microsphere preparation and preparation method thereof

A microsphere agent and microsphere technology, applied in the fields of medical cosmetology and biomedicine, can solve the problems of long-term foreign body reaction, short maintenance time and aseptic inflammation of permanent injection fillers, and achieve the promotion of soft tissue regeneration, uniform shape, The effect of preventing degradation

Active Publication Date: 2019-10-15
王月玲 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are many kinds of injectable beauty products on the market, but there are still many deficiencies in the existing products. For example, most of the degradable injectable fillers only play the role of physical filling, the maintenance time is short, and repeated injections are required; permanent injectable fillers exist Long-term foreign body reaction can easily lead to aseptic inflammation and cannot be removed

Method used

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  • Injection filling microsphere preparation and preparation method thereof
  • Injection filling microsphere preparation and preparation method thereof
  • Injection filling microsphere preparation and preparation method thereof

Examples

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Effect test

Embodiment 1

[0056] The preparation of embodiment 1 microspheres and gel

[0057] To 20L mass concentration of 0.2% polyvinyl alcohol 1788 (low viscosity type) aqueous solution, add 6L mass concentration of 2% polylactide (intrinsic viscosity is 0.4dl / g) dichloromethane solution, stir for 3 hours, The stirring speed is 350rpm, and the mixture in the reactor is released. Suction filtration, vacuum drying, ready for filling.

[0058] Add 30 g of mannitol and 30 g of hydroxymethyl methylcellulose sodium into 1 L of water for injection, stir at 30° C. at a stirring speed of 350 rpm, and form a gel after fully dissolving.

Embodiment 2

[0059] The preparation of embodiment 2 microspheres and gel

[0060] To 10L mass concentration of 0.5% polyvinyl alcohol 1788 (low viscosity type) aqueous solution, add mass concentration of 10L5% polylactide (intrinsic viscosity is 1.0dl / g) chloroform solution, stir for 8 hours, stirring speed 500rpm , release the mixture in the reactor. Suction filtration, vacuum drying, ready for filling.

[0061] Add 50 g of glucose and 30 g of hydroxypropyl methylcellulose sodium into 1 L of water for injection, stir at 20° C. at a stirring speed of 350 rpm, and form a gel after fully dissolving.

Embodiment 3

[0062] The preparation of embodiment 3 microspheres and gel

[0063] To 20L mass concentration is 1.0% polyvinyl alcohol 1788 (low viscosity type) aqueous solution, add 15L mass concentration as 10% polylactide (intrinsic viscosity is 2.0dl / g) ethyl acetate solution, stir 15 hours, The stirring speed is 650rpm, and the mixture in the reaction kettle is released; it is filtered, vacuum-dried, and prepared for filling.

[0064] Add 26 g of glycerin and 28 g of sodium carboxymethylcellulose into 1 L of water for injection, stir at 50° C. at a stirring speed of 350 rpm, and form a gel after fully dissolving.

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Abstract

The invention relates to an injection filling microsphere preparation and a preparation method thereof, and belongs to the technical field of medical beauty and biological medical treatment. The injection filling microsphere preparation provided by the invention comprises a microsphere agent and a gel agent. The microsphere agent is PGLA microspheres with a particle size of 5-200 microns; and thegel agent is gel prepared from an osmotic pressure regulator and a gel matrix. The osmotic pressure regulator is one or more of mannitol, glycerol, glucose or sodium chloride; and the gel matrix is one or more of carboxymethyl cellulose, hydroxypropyl methyl cellulose sodium or methyl cellulose sodium. The injection filling microsphere preparation provided by the invention can be used in the fieldof plastic beauty. The product has uniform sphere shape and controllable particle size specification, and has good biocompatibility and moderate degradation time. The degradation product can be completely absorbed by human bodies without leaving residue in the human bodies. The injection filling microsphere preparation is a microsphere preparation capable of resisting aging, beautifying skins andkeeping face rejuvenation by injection filling modification.

Description

technical field [0001] The invention belongs to the technical fields of medical cosmetology and biomedicine, and in particular relates to an injection-filled microsphere preparation and a preparation method thereof. Background technique [0002] It has become a common phenomenon to correct soft tissue defects and repair aging and wrinkled skin through plastic surgery technology, so as to maintain the perfect and youthful facial shape. Among various plastic surgery techniques, injection beauty technology accounts for the largest proportion, accounting for about 40% of the entire beauty market. Injection beauty technology is a beauty technology that partially modifies the human body through injection to achieve exquisite local shape and harmonious overall shape. This technology has the characteristics of zero recovery, quick effect and high safety, and is the first choice for beauty needs. [0003] At present, there are many kinds of injectable beauty products on the market,...

Claims

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Application Information

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IPC IPC(8): A61L27/16A61L27/18A61L27/20A61L27/50A61L27/52A61L27/58
CPCA61L27/16A61L27/18A61L27/20A61L27/50A61L27/52A61L27/58A61L2300/622A61L2400/06C08L67/04C08L29/04C08L1/284C08L1/286C08L1/28
Inventor 王月玲
Owner 王月玲
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