Urine special protein composite quality control substance and preparation method thereof

Abstract

The invention relates to the technical field of urine special protein detection, in particular to a urine special protein composite quality control substance and a preparation method thereof, the quality control substance comprises a low-value positive quality control substance and a high-value positive quality control substance, and the low-value positive quality control substance and the high-value positive quality control substance respectively comprise a buffer agent, urea, salts, a preservative, creatinine, PH, a protein protective agent, a stabilizer, human albumin, transferrin, retinolconjugated protein, alpha1-microglobulin, beta2-microglobulin, immune globulin G, neutrophil gelatinase associated lipocalin. The urine special protein composite quality control substance and the preparation method thereof provided by the invention have the advantages of simple operation, instant use after decapping, good stability, low production cost and easiness to achieve the quality control of a urine special protein detection system.

Description

technical field [0001] The invention relates to the technical field of urine special protein detection, in particular to a urine special protein composite quality control substance and a preparation method. Background technique [0002] With the increasing incidence of kidney disease patients, kidney disease has become a global public health problem. Patients with kidney disease have a long asymptomatic period before the appearance of obvious clinical symptoms, and it is difficult to detect relatively early kidney damage without screening. Renal puncture histopathological examination is the most reliable method for diagnosing renal injury, but it is technically demanding and traumatic, so it is not easy to popularize. The detection of urinary specific protein is one of the hotspots in the diagnosis and treatment of kidney diseases, and the detection of specific protein content in urine has important clinical diagnostic value for the diagnosis of kidney disease. [0003] In...

AI Technical Summary

Problems solved by technology

At present, the commonly used quality control products are mostly single-item quality control products. In the process of use, customers need to open multiple bottles of quality control products to carry out multiple special protein control projects. The operation is cumbersome, error-prone, and non-urine-based quality control products. There is a certain matrix effect

[0004] An existing patent number is "CN201610674109.2", and the patent name is a Chinese invention patent titled "a highly stable biochemical special protein liquid composite quality control product". The disclosed quality control product can detect anti-streptococcus O, C-reactive protein, complement C3, complement C4, IgM, IgA, IgG, prealbumin, rheumatoid factor, transferrin, total protein, albumin 12 substances, as the quality control of these 12 substances, is The quality control is carried out based on the corresponding protein content in serum, and the content of various proteins is relatively high. Taking the transferrin project as an example, the content range of transferrin is 2600-2800mg / L, and the protein content is high, which is similar to that of special Compared with the protein content value, there is a large difference, the probability of detection error is high, and the protein content is high, and the storage stability is relatively easy to achieve. However, if the corresponding protein content in urine is used as the benchmark, due to the low corresponding protein content, the corresponding Poor stability of quality control substances, difficult to store

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