External preparation of simvastatin and application of external preparation

A technology for external preparations and simvastatin, which is applied in the field of external preparations of simvastatin, can solve the problems of pigmentation, repeated treatment, skin loss, etc., and achieves the effects of increasing aggregation concentration, reducing side effects, and avoiding side effects.
CN110368358AActive Publication Date: 2019-10-25XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
Publication Date
2019-10-25

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Abstract

The invention relates to the technical field of pharmaceutical preparations, in particular to an external preparation of simvastatin and an application of the external preparation. The external preparation is composed of simvastatin and pharmaceutically acceptable auxiliary materials. The preparation can effectively treat CHILD (congenital hemidysplasia with ichthyosiform erythroderma and limb defects) syndrome and xanthomatosis. The preparation has the advantages of convenient treatment, safety, low price, fat solubility, no trauma, easy observation of curative effect and low recurrence rate;high concentration of drugs in the target site of the skin increases the curative effect and reduces the systematic side effects of a simvastatin oral preparation; for patients with xanthomatosis whoare not suitable for or unwilling to be treated with oral lipid-lowering drugs for a long time, the effect of treating skin lesions is achieved, and adverse reactions caused by the absorption of thedrug system is avoided.
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Description

technical field

[0001] The invention relates to the technical field of pharmaceutical preparations, in particular to an external preparation of simvastatin and its application. Background technique

[0002] CHILD (Congenital hemidysplasia with ichthyosiform erythroderma and limb defects) syndrome is a rare X-linked dominant genetic disease. It is characterized by congenital hemidysplasia with ichthyosis-like or verrucous hyperplasia-like skin lesions on the same side and limb deformities on the same side, and is fatal in males. The NSDHL gene on the Xq28 chromosome is the only causative gene of the disease found so far. The NSDHL gene encodes 3β-hydroxysteroid dehydrogenase, and mutations in this gene lead to disorders of cholesterol synthesis and accumulation of upstream toxic products. This local abnormality of lipid metabolism enables macrophages to phagocytose a large number of lipid droplets to form foam cells, eventually leading to the characteristic skin lesions of ...

Claims

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