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New cosmetic composition and preparation method and application thereof

A technology of cosmetic composition and compound, which is applied in the direction of cosmetic preparations, cosmetics, dressing preparations, etc., to achieve the effect of simple production process, low cost and good stability

Pending Publication Date: 2019-11-05
EAST CHINA NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] To sum up, research on LAE has been carried out in the prior art, but there are no related reports on the use of LAE, or even LAE derivatives, in cosmetics for anti-corrosion and anti-mildew

Method used

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  • New cosmetic composition and preparation method and application thereof
  • New cosmetic composition and preparation method and application thereof
  • New cosmetic composition and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Example 1: The preparation method of the ion-pair compound synthesized by lauroyl arginine ethyl ester hydrochloride and nicotinic acid

[0057] Dissolve 2.0 g of sodium nicotinate (purchased from TCI (Shanghai) Chemical Industry Development Co., Ltd.) in 50 mL of water to prepare sodium nicotinic acid salt solution (A); dilute 6.8 g of ethyl lauroyl arginate hydrochloride Dissolve in 40mL of water, heat to 90°C until ethyl lauroyl arginine hydrochloride is completely dissolved to make ethyl lauroyl arginine hydrochloride aqueous solution (B); Slowly add the saline solution (A) into the aqueous solution of lauroyl arginine ethyl ester hydrochloride (B), stir continuously, react for 2 hours, cool to room temperature, filter, wash the precipitate fully with pure water, and dry the precipitate under vacuum at 60°C. That is, 7.6 g of the nicotinic acid ion pair compound was obtained.

Embodiment 2

[0058] Example 2 The analysis of the molecular formula and molecular weight of the compound molecular formula and molecular weight of ethyl lauroyl arginate nicotinic acid ion

[0059] by mass spectrometry, 1 H-NMR, 13 The molecular formula of the compound obtained by C-NMR spectral analysis is:

[0060] 1. Mass spectrometry (ESI) analysis

[0061] Cation B + Molecular ion peak at m / z=385.3, see figure 1 ;

[0062] Anion A - Molecular ion peak at m / z = 122.1, see figure 2 .

[0063] The theoretically calculated value of the cation in the nicotinic acid ion-pair compound is 507.4, and the measured value is consistent with the theoretical value.

[0064] 2. NMR analysis

[0065] Ethyl lauroyl arginate hydrochloride (see image 3 ), niacin 1 H-NMR (see Figure 4 ) and LAE nicotinic acid ion pair compound 1 H-NMR (see Figure 5 )Compared. Since the LAE ion-pair compound has little change in the peak shape and chemical shift of lauroyl arginine ethyl ester in the io...

Embodiment 3

[0066] Example 3: Preparation method of ethyl lauroyl arginine hydrochloride and tartaric acid synthetic ion pair compound

[0067] Dissolve 2.0 g of tartaric acid (purchased from TCI (Shanghai) Chemical Industry Development Co., Ltd.) in 50 mL of methanol, add an equivalent amount of NaOH, stir at room temperature until a white solid precipitates, filter with suction and wash three times with 30 mL of methanol to obtain sodium tartrate . Sodium tartrate salt was dissolved in 50mL of water to make sodium tartrate aqueous solution (A); Dissolve 5.6g of ethyl lauroyl arginine hydrochloride in 40mL of water and heat to 90°C until ethyl lauroyl arginine salt The acid salt was completely dissolved to make ethyl lauroyl arginine hydrochloride aqueous solution (B); at 90°C, sodium tartrate aqueous solution (A) was slowly added to ethyl lauroyl arginine hydrochloride aqueous solution ( In B), stir continuously, react for 2 hours, cool to room temperature, filter, wash the precipitate...

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Abstract

The invention provides a preservative for cosmetics. The preservative comprises ethyl lauroylarginate (LAE) ion pair derivatives. The invention further provides a method for preparing the cosmetics containing the preservative and a cosmetic composition prepared by the method. For the cosmetic composition, the preservative has the characteristics of being natural, non-toxic, efficient, antibacterial, easy to degrade, and environmentally-friendly.

Description

technical field [0001] The present invention relates to a cosmetic composition, in particular to a cosmetic composition containing ethyl lauroyl arginine derivatives (ion pair compound), the ethyl lauroyl arginine ion pair has an antibacterial effect and can help the cosmetic composition While exerting the makeup and beautifying function, it can also keep the composition stable and exert antibacterial effect. Background technique [0002] Cosmetics refer to smearing, spraying or other similar methods that are spread on any part of the human body surface, such as skin, hair, nails, lips and teeth, etc., to achieve cleaning, maintenance, beauty, modification and change of appearance, or to correct human body odor, maintain Chemical industrial products or fine chemical products for the purpose of good condition. [0003] Since cosmetics contain many organic nutrients, in order to prevent these nutrients from producing bacteria and causing skin care products to deteriorate, pre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/44A61Q19/00
CPCA61K8/44A61Q19/00A61K2800/524A61K2800/10
Inventor 易正芳邵婷仇文卫刘明耀
Owner EAST CHINA NORMAL UNIV
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