Copper-based nano-composite structure-based portable micro-glucose enzyme-free sensing electrode as well as preparation method and application thereof

A nano-composite, sensing electrode technology, applied to the preparation of copper-based nano-composite structure micro-sensing electrodes, the application field of sensing electrodes in the rapid detection of glucose, can solve unfavorable industrialization, high preparation costs, and complicated process conditions and other issues, to achieve the effect of improving stability, improving performance, and increasing active sites

Inactive Publication Date: 2019-12-03
广州钰芯传感科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this method needs to be prepared at high temperature, and the process conditions are complicated, and the preparation cost is high, which is not conducive to industrialization

Method used

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  • Copper-based nano-composite structure-based portable micro-glucose enzyme-free sensing electrode as well as preparation method and application thereof
  • Copper-based nano-composite structure-based portable micro-glucose enzyme-free sensing electrode as well as preparation method and application thereof
  • Copper-based nano-composite structure-based portable micro-glucose enzyme-free sensing electrode as well as preparation method and application thereof

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preparation example Construction

[0056] A method for preparing a portable miniature glucose-free enzyme-free sensing electrode based on a copper-based nanocomposite structure, specifically comprising the following steps:

[0057] (1) Platinum plating on the counter electrode of the standard integrated three electrodes;

[0058] (2) modify silver-silver chloride on the reference electrode of the standard integrated three electrodes;

[0059] (3) Electrodeposit a copper layer on the working electrode of the standard integrated three electrodes;

[0060] (4) Gold-tin alloy is electrodeposited on the front of the working electrode, and then metal tin is removed to obtain an electrode modified with nanoporous copper;

[0061] (5) The working electrode is oxidized in an alkaline solution to obtain a nanoporous copper electrode with a surface-modified copper oxide nano-coral array.

[0062] Further, in step (1), the platinum plating solution consists of H 2 PtCl 6 1 mM and KCl 0.1M.

[0063] Further, in step (...

Embodiment 1

[0071] Preparation of NCA / NPC composite electrodes:

[0072](1) The counter electrode of the standard integrated three-electrode is connected separately, and the standard platinum electrode is used as the counter electrode, so that it is electrodeposited at the potential of -0.4V for 15 minutes, and the platinum plating solution is composed of H 2 PtCl 6 1 mM and KCl 0.1M.

[0073] (2) Connect the reference electrode of the standard integrated three-electrode separately, and use the silver wire electrode as the counter electrode to make it work at 25°C with a current density of 0.3A / dm 2 The silver plating-silver chloride solution is composed of: silver nitrate 40g / L, sodium thiosulfate 200g / L, potassium metabisulfite 40g / L, ammonium acetate 20g / L, thiosemicarbazide 0.6g / L.

[0074] (3) Wash, degrease, and wash the standard integrated three-electrode modified counter electrode and reference electrode, and then connect the working electrode separately, use it as the cathode...

Embodiment 2

[0081] Preparation of NCA / NPC composite electrodes:

[0082] (1) The counter electrode of the standard integrated three-electrode is connected separately, and the standard platinum electrode is used as the counter electrode, so that it is electrodeposited at the potential of -0.4V for 15 minutes, and the platinum plating solution is composed of H 2 PtCl 6 1 mM and KCl 0.1M.

[0083] (2) Connect the reference electrode of the standard integrated three-electrode separately, and use the silver wire electrode as the counter electrode to make it work at 25°C with a current density of 0.3A / dm 2 The silver plating-silver chloride solution is composed of: silver nitrate 40g / L, sodium thiosulfate 200g / L, potassium metabisulfite 40g / L, ammonium acetate 20g / L, thiosemicarbazide 0.6g / L.

[0084] (3) Wash, degrease, and wash the standard integrated three-electrode modified counter electrode and reference electrode, and then connect the working electrode separately, use it as the cathod...

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Abstract

The invention provides a copper-based nano-composite structure-based portable micro-glucose enzyme-free sensing electrode as well as a preparation method and an application thereof. The invention provides the high-efficiency sensing electrode based on the porous copper and copper oxide composite material, so that the electrode can be endowed with the excellent conductivity of copper and the excellent catalytic performance of copper oxide; the electrode adopts a three-electrode coplanar system, the size of the electrode is matched with that of a USB, the micro sensing electrode is formed, and the micro sensing electrode can be directly connected with an electrochemical workstation. The NCA / NPC composite electrode provided by the invention is relatively high in sensitivity, extremely low indetection limit, relatively wide in detection range, excellent in stability and anti-interference performance, wherein the sensitivity of the composite electrode is 1621[mu]A / mM.cm2 within the detection range of 0.5-5.0mM, the detection limit is 338nM, the response time is less than 3s, and the electrode can be applied to actual detection of human blood sugar.

Description

technical field [0001] The invention belongs to the field of sensors for glucose detection, and relates to a method for preparing a copper-based nanocomposite structure miniature sensing electrode for detecting glucose without enzymes, in particular to the application of the sensing electrode in rapid glucose detection. Background technique [0002] Glucose is a simple but important monosaccharide that circulates in the human body as blood sugar. Proper levels of blood sugar can help improve memory and cognitive performance. Too low a level can lead to hypoglycemia or insulin shock Hyperglycemia can lead to obesity or diabetes. Diabetes is one of the most common diseases in the world. In recent decades, the incidence of diabetes has been increasing, and it has been listed as one of the four major non-communicable diseases. Diabetes is a chronic disease that can cause various complications such as vision loss, renal failure, retinopathy, and stroke. The effective detection a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/30G01N27/327
CPCG01N27/30G01N27/3278
Inventor 奚亚男胡淑锦
Owner 广州钰芯传感科技有限公司
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