A kind of external chondroitin sulfate nano composition and its preparation method and application

A chondroitin sulfate and nano-composite technology, applied in the field of medicine, can solve problems such as being difficult to meet clinical treatment needs, reducing bioavailability and the like
CN110548003BActive Publication Date: 2021-07-06JILIN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JILIN UNIV
Publication Date
2021-07-06

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Abstract

The invention provides a nanometer composition of chondroitin sulfate for external use and its preparation method and application, which belong to the field of medicine. The nano composition provided by the invention comprises the following components in mass percentage: 5-100% of nano drug system, 5-40% of moisturizing agent and 10-90% of drug carrier, and the sum of the amounts of each component is 100%. The nano-composition prepared by using a specific amount of each component raw material in the present invention has a structure similar to a biofilm, including an oil phase and a water phase, which is similar to the bilayer structure of the skin. According to the principle of similar miscibility, the present invention provides The nano composition can soften the cuticle of the skin, quickly penetrate the cuticle and subcutaneous tissue of the skin surface, enter the joint cavity, be directly absorbed at the bone joint, and maintain the drug concentration required for treatment in the joint cavity for a long time to treat joint diseases. Relieve pain and joint discomfort, convenient administration, no skin irritation, no discomfort.
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Description

Technical field

[0001] The present invention relates to the field of medicine, and more particularly to a sulfate chondroitin external nano composition and a preparation method thereof. Background technique

[0002] The chondrogen sulfate has the effect of protecting the joint, and can provide a matting force, mitigate the impact and friction of the joint, which can inhale moisture into the protein polysaccharide molecule, so that the cartilage is thicker, and increase the amount of slid fluid in the joint is the treatment. First-line drug for osteoarthrosis. One of the important functions of the cartonin, as the conveying pipe, transporting important oxygen and nutrients to the joint, and helps remove carbon dioxide and waste in the joint; sulfate has the effect of promoting cartilage regeneration, and can fundamentally improve joint problems .

[0003] At present, the Food and Drug Administration approves the commercially available sulfate sulfuric acid chondroitin products inc...

Claims

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