A kind of external chondroitin sulfate nano composition and its preparation method and application

A chondroitin sulfate and nano-composite technology, applied in the field of medicine, can solve problems such as being difficult to meet clinical treatment needs, reducing bioavailability and the like

Active Publication Date: 2021-07-06
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, oral dosage forms have liver first-pass and gastrointestinal degradation, which reduces bioavailability, and after oral administration, the amount of medicine that can reach bone joints, especially knee joints, is very limited, which is difficult to meet the needs of clinical treatment; The need for medical care conditions guarantees, and there are pain and risks at the same time

Method used

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  • A kind of external chondroitin sulfate nano composition and its preparation method and application
  • A kind of external chondroitin sulfate nano composition and its preparation method and application
  • A kind of external chondroitin sulfate nano composition and its preparation method and application

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preparation example Construction

[0036] The present invention also provides the preparation method of the oculomyne sulfate external nano composition of the above-described technical solution, including the following steps:

[0037] Sodium polyacrylate, citric acid, polyvinyl alcohol, gelatin, carboxymethylcellulose, polyvinylpyrrolidone and water are first mixed to obtain a pharmaceutical carrier;

[0038] The propanol, 1,2 propylene glycol and polyethylene glycol were mixed to obtain a moisturizer;

[0039] Ethyl oleate, Tween-80, glycerol, hyaluronic acid, chondroitin, and water, to obtain a nano-pharmaceutical system;

[0040] The pharmaceutical carrier, a moisturizing agent, and a nanopharmaceutical system are mixed to obtain an external nano-composition of the sulfate chondroitin.

[0041] The present invention results in a pharmaceutical carrier after the first mixing of sodium polyacrylate, citric acid, polyvinyl alcohol, gelatin, alcohol, polyvinylpyrrolidone, and water.

[0042] The present invention is...

Embodiment 1

[0053] According to the mass ratio of sodium polyacrylate: polyvinyl alcohol: gelatin: sodium carboxymethylcellulose: polyvinylpyrrolidone = 20: 10: 10: 2: 5, weighing the above raw materials;

[0054] Sodium polyacrylate and water were mixed under 90 ° C to obtain a polyacrylate solution having a mass percentage of 90%, and citric acid was adjusted using citric acid to adjust the pH of the polyacrylate solution. After adjusting to pH = 6, add poly Vinyl alcohol, stir well at 50 ° C, to obtain suspension, spare of sodium polyacrylate and polyvinyl alcohol;

[0055] The proportion of gelatin and water was mixed under 40 ° C in a ratio of 3: 1, and gelatin solution was obtained.

[0056] The carboxymethylcellulose sodium carboxymethylcellulose and water were mixed under 70 ° C to obtain a carboxymethylcellulose solution having a mass percentage of 80%, spare;

[0057] The suspension of the prepared polyacrylate and polyvinyl alcohol, gelatin solution, and carboxymethylcellulose sodi...

Embodiment 2

[0073] According to the mass ratio of polyacrylate: polyvinyl alcohol: gelatin: sodium carboxymethylcellulose: polyvinylpyrrolidone = 40: 5: 10: 2: 5, respectively weigh the above raw materials;

[0074] Sodium polyacrylate and water were mixed under 90 ° C to obtain a polyacrylate solution having a mass percentage of 80%, and citric acid was adjusted using citric acid to adjust the pH of the sodium polyacrylate solution, and then added to pH = 6. Vinyl alcohol, stir well at 50 ° C, to obtain suspension, spare of sodium polyacrylate and polyvinyl alcohol;

[0075] The proportion of gelatin and water was mixed under 40 ° C in a ratio of 3: 1, and gelatin solution was obtained.

[0076] The carboxymethylcellulose sodium carboxymethylcellulose and water were mixed under 50 ° C to give a hydrochlormethylcellulose solution, spare of a mass percentage of 70%.

[0077] The suspension of the prepared polyacrylate and polyvinyl alcohol, gelatin solution, and carboxymethylcellulose sodium s...

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Abstract

The invention provides a nanometer composition of chondroitin sulfate for external use and its preparation method and application, which belong to the field of medicine. The nano composition provided by the invention comprises the following components in mass percentage: 5-100% of nano drug system, 5-40% of moisturizing agent and 10-90% of drug carrier, and the sum of the amounts of each component is 100%. The nano-composition prepared by using a specific amount of each component raw material in the present invention has a structure similar to a biofilm, including an oil phase and a water phase, which is similar to the bilayer structure of the skin. According to the principle of similar miscibility, the present invention provides The nano composition can soften the cuticle of the skin, quickly penetrate the cuticle and subcutaneous tissue of the skin surface, enter the joint cavity, be directly absorbed at the bone joint, and maintain the drug concentration required for treatment in the joint cavity for a long time to treat joint diseases. Relieve pain and joint discomfort, convenient administration, no skin irritation, no discomfort.

Description

Technical field [0001] The present invention relates to the field of medicine, and more particularly to a sulfate chondroitin external nano composition and a preparation method thereof. Background technique [0002] The chondrogen sulfate has the effect of protecting the joint, and can provide a matting force, mitigate the impact and friction of the joint, which can inhale moisture into the protein polysaccharide molecule, so that the cartilage is thicker, and increase the amount of slid fluid in the joint is the treatment. First-line drug for osteoarthrosis. One of the important functions of the cartonin, as the conveying pipe, transporting important oxygen and nutrients to the joint, and helps remove carbon dioxide and waste in the joint; sulfate has the effect of promoting cartilage regeneration, and can fundamentally improve joint problems . [0003] At present, the Food and Drug Administration approves the commercially available sulfate sulfuric acid chondroitin products inc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K31/737A61K47/10A61K47/26A61K47/32A61K47/38A61K47/42A61P19/02B82Y5/00
CPCA61K9/0014A61K9/06A61K31/737A61K47/10A61K47/26A61K47/32A61K47/38A61K47/42A61P19/02B82Y5/00
Inventor 丁志英韩腾飞翟婉辰王静仪姜悦垚庄宁
Owner JILIN UNIV
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