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Use of hemoglobin and hemoglobin derivatives in preparing injection preparation for improving immune function

A technology of hemoglobin and pharmaceutical preparations, applied in the field of biomedicine, can solve problems such as damage to the nervous system, digestive system, and mental confusion of patients, and achieve the effect of improving immune function, high safety, and small dosage

Pending Publication Date: 2019-12-10
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, levamisole, pidotimod, interferon, etc. have been found in clinical practice to seriously damage the nervous system and digestive system of patients, leading to side effects such as mental confusion in patients

Method used

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  • Use of hemoglobin and hemoglobin derivatives in preparing injection preparation for improving immune function
  • Use of hemoglobin and hemoglobin derivatives in preparing injection preparation for improving immune function
  • Use of hemoglobin and hemoglobin derivatives in preparing injection preparation for improving immune function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] In the experiment, firstly, 100 mg / kg cyclophosphamide (CTX) was injected intraperitoneally into ICR mice for 5 consecutive days to establish an immunocompromised (immunosuppressed) mouse model. On the third day of modeling, porcine hemoglobin (Hb) or porcine hemoglobin (Hb) or Polyporcine hemoglobin (pPolyHb) was continuously injected for 7 days; in the same way, a positive control group with thymopentin (TP) injection solution (0.33mg / kg), a negative control group with equal volume of normal saline, and no treatment were given every day. An equal volume of normal saline was used as the normal control group. The timeline of mouse modeling, drug injection and sampling points is shown in figure 1 shown. After the test is completed, the white blood cell count, immune-related factors, spleen index measurement, carbon clearance test and other detections are carried out respectively.

[0052] test results:

[0053] 1.1 Effect of porcine Hb and pPolyHb on the total number ...

Embodiment 2

[0066] In the experiment, the Balb / C mouse model of radiation injury and immunocompromise was first established (the whole body of the Balb / C mouse was irradiated 15 minutes away from the qinlon ray for 5 consecutive days), and bovine hemoglobin (0.07mg / kg ), bovine methemoglobin (0.5mg / kg), human carboxyhemoglobin (0.5mg / kg), canine deoxyhemoglobin (2mg / kg), double aspirin cross-linked sheep hemoglobin (16mg / kg), chicken sulphated hemoglobin (15mg / kg) kg) and polymerized bovine hemoglobin mixture (15mg / kg), injected continuously for 7 days; in the same way, a positive control group thymopentin (TP) injection solution (0.33mg / kg), a negative control group with equal volume of normal saline, and no After any treatment, an equal volume of normal saline was given every day as a normal control group. After the test was completed, the immune-related factors and spleen index were measured respectively.

[0067] test results:

[0068] 2.1 Effects of different hemoglobin derivatives...

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PUM

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Abstract

The invention provides a use of hemoglobin and hemoglobin derivatives in preparing an injection preparation for improving the immune function, wherein the hemoglobin derivatives include derivatives with the hemoglobin as a matrix and processed and modified hemoglobin in various types. An administration route can be abdominal abministration, intravenous administration, intramuscular injection abministration and the like without containing oral administration, and a dosage range (by hemoglobin) is 0.01-50mg / kg / day. When the organism immunity is low, the partial immune function can be remarkablyimproved by injecting the hemoglobin or a hemoglobin derivative solution into a body.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a new medical application of hemoglobin (Hb) and hemoglobin derivatives. Background technique [0002] Natural hemoglobin usually plays the role of carrying oxygen and releasing oxygen in red blood cells to supply the body with oxygen. Hemoglobin has a molecular weight of 64.5KD and contains four subunits, two α subunits and two β subunits. Each subunit in Hb is composed of a peptide chain and a heme (heme) molecule, and there is a ferrous iron on each heme molecule. Hemoglobin containing divalent iron is called ferrous hemoglobin, which has the function of carrying oxygen and releasing oxygen; among them, ferrous hemoglobin combined with oxygen is called oxyhemoglobin (O 2 Hb), the ferrous hemoglobin without oxygen is called deoxyhemoglobin (HHb). Iron hemoglobin is easily converted into other forms of hemoglobin, such as methemoglobin (metHb) (hemoglobin in which ferro...

Claims

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Application Information

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IPC IPC(8): A61K38/42A61K9/00A61P37/04
CPCA61K38/42A61K9/0019A61P37/04A61K2300/00
Inventor 严坤平
Owner NORTHWEST UNIV
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