A rare earth nanomaterial containing polystyrene shell and its biocoupling and application

A technology of rare earth nanomaterials and polystyrene, which is applied in nanotechnology for materials and surface science, luminescent materials, analytical materials, etc., can solve problems such as difficult to guarantee stability, weak covalent interaction, and antibody shedding, and achieve The effect of strong connection stability and good material dispersion

Active Publication Date: 2020-12-01
FUDAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the disadvantages of the above method are: first, ligand exchange easily leads to aggregation between nanoparticles; The valency is much weaker, and it is easily disconnected by the influence of interfering substances in the solution, so the antibody on the particle surface may fall off at any time in a complex system
However, since silicon dioxide is obtained by the condensation reaction of silicon hydroxyl groups to form silicon-oxygen bonds, long-term storage in pure water will cause silicon-oxygen bond breaks and gradually dissolve, so the stability is difficult to guarantee
[0005] It has been reported in the literature that a polystyrene shell with a thick

Method used

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  • A rare earth nanomaterial containing polystyrene shell and its biocoupling and application
  • A rare earth nanomaterial containing polystyrene shell and its biocoupling and application
  • A rare earth nanomaterial containing polystyrene shell and its biocoupling and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] Example 1: β-NaYF 4 Synthesis and Luminescent Properties of :Yb,Er Cores

[0083] YCl 3 0.78mmol, YbCl 3 0.2mmol, ErCl 3 0.02mmol, OA (oleic acid oleic acid) 6mL and ODE (1-Octadecene octadecene) 15mL were added to a 100mL round bottom flask, heated to 150°C under vacuum until all the rare earth chlorides were dissolved, then cooled naturally to 60°C.

[0084] Add 2.5 mmol NaOH and 4 mmol NH dropwise to the cooled system 4 F in methanol solution 10mL, stirred for 30 minutes. After stirring, the system was heated to 150°C, and nitrogen was blown for 1 hour to remove methanol.

[0085] Under the protection of nitrogen, the reaction system was heated to 300°C and reacted for 1 h; after the reaction was completed, it was naturally cooled to room temperature.

[0086] Add 10mL of ethanol to the reaction product, centrifuge at 15000rpm for 10min, discard the supernatant solution; disperse the obtained solid in 10mL of cyclohexane, add 20mL of ethanol, and centrifuge ...

Embodiment 2

[0089] Example 2: β-NaYF 4 :Yb,Er@NaLuF 4 Synthesis of inner core and study of its luminescent properties

[0090] LuCl 3 Add 1mmol, 6mL of OA and 15mL of ODE into a 100mL round bottom flask, heat to 150°C under vacuum until all the rare earth chlorides are dissolved, and cool naturally to 90°C.

[0091] Add 200mgβ-NaYF to the cooled system 4 : Yb, Er core (embodiment 1) cyclohexane solution 10mL, heated to 150 ° C, nitrogen 1h to remove cyclohexane.

[0092] After cyclohexane was removed, it was naturally cooled to 60°C, and a solution containing 2.5mmol NaOH and 4mmol NH was added dropwise to the cooled system. 4 F in methanol solution 10mL, stirred for 30 minutes. After stirring, the system was heated to 150°C, and nitrogen was blown for 1 hour to remove methanol.

[0093] Under the protection of nitrogen, the reaction system was heated to 300° C. for 1 h. After the reaction was completed, it was naturally cooled to room temperature.

[0094] Add 10mL ethanol to the r...

Embodiment 3

[0097] Example 3: α-NaYF 4 :Synthesis of Yb, Nd Core and Study on Luminescent Properties

[0098] Take 2.84g (10mmol) oleic acid, 2.67g (10mmol) oleylamine, 5.04g (20mmol) octadecene, 1mmol rare earth trifluoroacetate (Y:Yb:Nd=33:7:60), 1mmol trifluoro Sodium acetate was placed in a 100ml three-neck bottle, and the system was sealed, pumped and heated to 110°C until a transparent and clear solution was formed.

[0099] Pump and exchange air three times, blow nitrogen, heat up to 300°C and react for 30 minutes; after the reaction, cool naturally, wash the three-necked flask with 3mL cyclohexane, add 10mL absolute ethanol, centrifuge at 15000rpm for 10min, and use about 20ml ethanol / cyclohexane for precipitation. Hexane mixed solution (ethanol / cyclohexane volume ratio 3 / 1) was washed three times, and the obtained α-NaYF 4 : Yb, Nd core stored in 10ml cyclohexane.

[0100] to α-NaYF 4 : Yb, Nd inner core was characterized by transmission electron microscopy, the results are a...

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Abstract

The invention discloses a rare earth nanomaterial containing a functionalized polystyrene shell. The rare earth nanomaterial comprises a core, a silica shell and the polystyrene shell; the core is rare earth luminescent nanoparticles, the silica shell is coated outside the core, and the silica shell is modified with double bonds; and the silica shell is coated with the polystyrene shell, and the polystyrene shell is modified with a functional group. The invention further discloses a preparation method of the rare earth nanomaterial containing the functionalized polystyrene shell. The rare earth nanomaterial containing the functionalized polystyrene shell has a good dispersity and a high stability, and can be applied to biological coupling, immunochromatography detection and hydrophobic molecule or nanoparticle embedding.

Description

technical field [0001] The invention belongs to the technical field of rare earth luminescent nanometer materials, and in particular relates to a rare earth nanometer material containing polystyrene shell and biological coupling and application thereof. Background technique [0002] Rare earth nanomaterials have good photostability and chemical stability, and have broad application prospects. Commonly used rare earth nanomaterials are obtained in oleic acid-octadecene mixed solvents, but the oleic acid ligands on the surface make the materials insoluble in water and difficult to perform surface functionalization, which greatly limits their applications in the biomedical field . [0003] At present, most rare earth nanomaterials are surface functionalized in the form of non-covalent bonds, such as hydrophilic-hydrophobic interactions, electrostatic adsorption, etc. F.Xu et al. used polyacrylic acid (PAA) to modify the surface of rare earth nanomaterials. Through the ligand ...

Claims

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Application Information

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IPC IPC(8): C09K11/02C09K11/06C09K11/85B82Y30/00B82Y40/00G01N33/53C08F292/00C08F220/06C08F212/08C08F212/36C07K16/00
CPCB82Y30/00B82Y40/00C07K16/00C08F292/00C09K11/025C09K11/06C09K11/7773C09K2211/14G01N33/5306C08F212/08
Inventor 李富友刘青昀冯玮吴勇
Owner FUDAN UNIV
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