Vaginal antibacterial preparation and preparation method thereof

A preparation and vaginal technology, applied in the direction of antifungal agents, local antibacterial agents, pill delivery, etc., can solve the problems of poor treatment effect of vaginitis, inconvenient use, and inability to exert antibacterial and beneficial bacterial growth effects at the same time. Achieve thorough treatment, less irritation to the human body, and significant curative effect

Active Publication Date: 2019-12-20
SHENZHEN DUOWEISHENG HEALTH FOOD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The problem to be solved by the present invention is that the products for the treatment of vaginitis in the prior art have poor therapeutic effects, ca

Method used

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  • Vaginal antibacterial preparation and preparation method thereof
  • Vaginal antibacterial preparation and preparation method thereof
  • Vaginal antibacterial preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] 1. Preparation of probiotic layer

[0035]Ultraviolet sterilizing treatment was carried out on the bean dregs, and as a culture medium, the strains of Lactobacillus acidophilus, Lactobacillus plantarum and Lactobacillus fermentum were taken, operated under sterile conditions, inoculated in the medium at 37°C, and cultivated for 36 hours. Centrifuge to obtain probiotic strains, disperse in normal saline for later use, and the number of probiotic bacteria is ≧6.5*10 8 cfu / ml.

[0036] Take 8g of polyvinyl alcohol, slowly add 100ml of hot water at 80°C while stirring, until the polyvinyl alcohol is completely dissolved, then cool to 50°C to obtain a polyvinyl alcohol sol, add the normal saline that disperses the probiotic cells In the polyvinyl alcohol sol, stir evenly to obtain the probiotic layer material.

[0037] 2. Preparation of isolation layer material

[0038] Take 50g of gelatin, add 100ml of cold water to soak for 2 hours, then gradually increase the temperatu...

Embodiment 2

[0044] The same method as in Example 1 was used to prepare the vaginal antibacterial preparation product, except that the material of the isolation layer also included 5 g of sucrose and 3 g of cellulose. The preparation method is as follows: slowly add 5g of sucrose and 3g of cellulose into 50ml of hot water at 80°C, stir and dissolve evenly, add it into the gelatin sol, and then slowly cool to 50°C to obtain the isolation layer material.

[0045] The final product is denoted as S2.

Embodiment 3

[0047] The same method as in Example 2 was used to prepare the vaginal bacteriostatic preparation product, except that the bacteriostatic composition was a chemical bacteriostatic agent of 7g chlorhexidine acetate and 8g octoxynol.

[0048] The final product is denoted as S3.

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Abstract

The invention discloses a vaginal antibacterial preparation and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The vaginal antibacterial preparation is of a multilayer structure and sequentially comprises a probiotic layer, an isolation layer and an antibacterial layer from inside to outside, and the mass ratio of the layers is 1: (0.5-3): (0.5-6);the probiotic layer comprises probiotics and a base material; the isolation layer comprises gelatin; and the antibacterial layer comprises hydrogel and an antibacterial composition. The vaginal antibacterial preparation has the effects of inhibiting bacteria, isolating and promoting proliferation of probiotics, maintains ecological balance of flora in a vagina through a biological regulation method, and is small in irritation to a human body, remarkable in vaginitis treatment effect, long in lasting time, and convenient to use, and vaginitis is not prone to relapsing.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a vaginal antibacterial preparation and a preparation method thereof. Background technique [0002] Vaginitis is a common female disease, which is caused by the special physiological structure of women. There are a lot of folds and dead spots in the female vagina, which is not easy to clean. During menstruation and pregnancy, the body resistance of women decreases. At this time, harmful bacteria will multiply and damage the skin. The normal ecological balance in the female vagina then leads to vaginitis, which is clinically manifested as itching, burning pain, abnormal leucorrhea and other symptoms, which brings serious discomfort to the female body. Therefore, it is necessary to treat female vaginitis in time to ensure the physical and mental health of women. Treatment of vaginitis can start from the following two aspects: [0003] First, add ben...

Claims

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Application Information

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IPC IPC(8): A61K35/747A61K9/00A61K9/20A61K47/42A61P15/02A61P31/02A61P31/10A61K31/155A61K31/765
CPCA61K9/0034A61K9/2063A61K31/155A61K31/765A61K35/747A61K36/234A61K36/489A61K36/61A61K36/756A61K47/42A61P15/02A61P31/02A61P31/10A61K2300/00
Inventor 张义淦陈寻丹陈嘉敏
Owner SHENZHEN DUOWEISHENG HEALTH FOOD
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