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Biomacromolecule skin care product with flexible nanoliposome as carrier and preparation method of biomacromolecule skin care product

A technology of nano-liposomes and biomacromolecules, applied in cosmetic preparations, skin care preparations, medical preparations containing active ingredients, etc., can solve the problem of liposome vesicles entering deep skin cells and low encapsulation efficiency and other problems, to achieve the effect of good coating, stable shape of the finished product, and high encapsulation rate

Pending Publication Date: 2020-01-10
张瀚文
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ordinary liposomes generally adopt a rigid design in order to maintain stability during storage and circulation in the blood, but this design is not conducive to liposome vesicles entering the deep skin cells through the stratum corneum gap
In addition, when water-soluble active ingredients are loaded with liposomes, the encapsulation efficiency is often very low

Method used

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  • Biomacromolecule skin care product with flexible nanoliposome as carrier and preparation method of biomacromolecule skin care product
  • Biomacromolecule skin care product with flexible nanoliposome as carrier and preparation method of biomacromolecule skin care product
  • Biomacromolecule skin care product with flexible nanoliposome as carrier and preparation method of biomacromolecule skin care product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Weigh and mix 493g of deionized water, 20g of sodium cholate, 10g of Tween-60, 50g of ascorbic acid, 10g of hexapeptide, 2g of oligopeptide-1, 50g of allantoin, 10g of sodium hyaluronate, and 50g of licorice extract, Heat to 60°C and stir with 200r / min magnetic force until all components are completely dissolved. Continue to insulate and stir for 30 minutes to become the water phase.

[0040] Mix 50g of hydrogenated soybean lecithin, 20g of octadecylamine, 100g of ethanol, 10g of Span-60, 50g of tocopherol, and 50g of green tea extract, heat to 60°C, and stir with 100r / min magnetic force to dissolve completely. Continue to insulate and stir for 30 minutes to become the organic phase. Slowly inject the mixed organic phase into the water phase, while maintaining temperature control at 60°C, and quickly mix the two phases with 500r / min magnetic stirring to form a liposome system. Stir continuously at temperature control for 5 minutes to ensure the uniformity and stability...

Embodiment 2

[0042] Weigh and mix 643g of deionized water, 16g of sodium cholate, 3g of ajirelin, 28g of Tween-80, 10g of ascorbic acid, 10g of carnosine, 10g of allantoin, and 20g of ectoine, and heat to 55°C, 600r / min Stir with a stirring paddle until the ingredients are completely dissolved. Continue to insulate and stir for 30 minutes to become the water phase. Weigh 50g of egg yolk lecithin, 100g of ethanol, 5g of stearylamine, 50g of chamomile extract, and 30g of green tea extract, and mix them, heat to 55°C, stir with 600r / min magnetic force to completely dissolve each component, and keep stirring for 10 minutes to become organic Mutually. Slowly inject the mixed organic phase into the water phase, while maintaining temperature control at 55°C, and quickly mix the two phases to form a liposome system with a high-speed shear of 7000r / min. After the organic phase is completely injected, continue to shear for 2 minutes to ensure uniformity of the system. Stable and become emulsified...

Embodiment 3

[0044] Mix 435g of deionized water, 11g of sodium cholate, 100g of yeast fermentation filtrate (containing about 10g of biological macromolecules, and the rest is water), 5g of glutathione, 50g of glycerin, 2g of phloretin, 10g of dipotassium glycyrrhizinate, rose 10g of eggplant extract was weighed and mixed, heated to 40°C, stirred magnetically at 500r / min until each component was completely dissolved, and kept stirring for 10 minutes to form a water phase. Mix 100g of hydrogenated soybean lecithin, 30g of octadecylamine, 200g of ethanol, 5g of retinyl propionate, and 20g of hydrogenated castor oil polyoxyethylene-40, heat to 40°C, and stir magnetically at 100r / min until all ingredients are completely dissolved Continue to insulate and stir for 10 minutes to become an organic phase. Slowly inject the mixed organic phase into the water phase, while maintaining temperature control at 50°C, and quickly mix the two phases at a high speed of 12000r / min to form a liposome system. ...

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Abstract

The invention provides a biomacromolecule skin care product with flexible nanoliposome as a carrier and a preparation method of the biomacromolecule skin care product. The biomacromolecule skin care product is prepared from the following components in percentage by mass: 0.05-10% of bioactive macromolecules, 0.5-20% of phospholipid, 20-80% of deionized water, 3-40% of ethyl alcohol, 0.1-10% of anemulsifier, 0.1-5% of octadecylamine, 0.05-3% of sodium cholate, 0.5-20% of an antioxidant, 2-20% of a humectant, 1-20% of a plant extract, 0.2-2% of a preservative, and 0.1-15% of a thickening agent,wherein the sum of the mass fraction of the components is 100%. The stability of active components is ensured through the flexible nanoliposome, the encapsulation efficiency of the water-soluble effective components is improved, through the flexible nanoliposome different from previous rigid liposome, the situation that the liposome carries the effective components to realize percutaneous permeability is better achieved, the problems of moisturizing, aging preventing and the like are comprehensively solved, and long-term stable preservation and permeability of the effective components are improved.

Description

technical field [0001] The invention belongs to the technical field of biological skin care products, and in particular relates to a biological macromolecular skin care product whose carrier is flexible nano-liposome and a preparation method thereof. Background technique [0002] Biological skin care products are a new source of active ingredients with bioactive protein as the core. Active protein is a complex organic compound. The basic unit of protein is amino acid, which forms a peptide chain through dehydration condensation. Protein is a biomacromolecule composed of one or more polypeptide chains, each polypeptide chain has twenty to hundreds of amino acid residues; various amino acid residues are arranged in a certain order. The development of biological fermentation purification technology has reduced the cost of obtaining active ingredients such as biologically active proteins, various growth factors, biological peptides, and oligopeptides, and made it possible to m...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/9771A61K8/73A61K8/67A61K8/64A61K8/63A61K8/14A61K8/49A61K8/55A61Q19/00A61Q19/08
CPCA61K8/9789A61K8/9771A61K8/735A61K8/676A61K8/64A61K8/63A61K8/4946A61K8/678A61K8/553A61K8/731A61K8/14A61Q19/00A61Q19/08A61K2800/56
Inventor 张瀚文
Owner 张瀚文
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