Preparation method and application of pH-response-type high-strength conductive hydrogel

A conductive hydrogel, high-strength technology, applied in the direction of medical preparations of non-active ingredients, pharmaceutical formulas, and diseases transmitted by vectors, can solve problems such as long reaction time, many cross-linking agents, and cumbersome processes, and achieve The effect of short preparation time, fast gelation speed and simple preparation process

Active Publication Date: 2020-02-04
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its disadvantages are: the amount of cross-linking agent is large, resulting in waste, and ethylene glycol diglycidyl ether has certain toxicity to the human body, and the reaction time is long, so it is necessary to pay attention to the reaction at intervals during the reaction process. The change of pH value, the hydrogel obtained by the reaction also needs to be swollen, dialyzed and freeze-dried. The process is relatively cumbersome, and there are obvious shortcomings in the mass preparation of materials.

Method used

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  • Preparation method and application of pH-response-type high-strength conductive hydrogel
  • Preparation method and application of pH-response-type high-strength conductive hydrogel
  • Preparation method and application of pH-response-type high-strength conductive hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Weigh 1g of γ-PGA powder and dissolve it in 10mL of ultrapure water. The molecular weight of γ-PGA is 200,000-2 million units. Use magnetic stirring for 2-3 hours to make it dissolve uniformly, and then add 1mL of GPTMS as a reactive cross-linking agent. Use magnetic stirring for 3-4 hours to obtain a clear translucent liquid, then add 4 mL of hydrolyzed tetraethyl orthosilicate (TEOS) clear and transparent solution with a mass content of 50%, and put the reaction solution in an oven at 37°C for 2-4 hours to obtain Hydrogels. figure 1 Hydrogel compression pictures were prepared for the addition of 4 ml TEOS hydrolyzate. It can be seen that the shape of the hydrogel does not undergo plastic deformation after compression, and the strength of the hydrogel is relatively good. The prepared hydrogels were put into PBS (PBS, 8mL, pH7.4) DOX 50μM and TET 200μM solutions for 48h, and the soaked hydrogels were rinsed with PBS for 3 times, and the prepared pH=1.2, 7.4 Put 8mL of...

Embodiment 2

[0032] Weigh 1g of γ-PGA powder and dissolve it in 10mL of ultrapure water, stir it for 2-3 hours to make it uniform, then add 1mL of GPTMS as a reactive cross-linking agent, and stir it for 3-4 hours to obtain a clear translucent liquid, then Add 2 mL of a hydrolyzed tetraethyl orthosilicate (TEOS) clear solution with a mass content of 50%, and place the reaction solution in an oven at 37°C for 4-6 hours to obtain a hydrogel. figure 2 Hydrogel compression pictures were prepared for addition of 2 mL LTEOS hydrolyzate. It can be seen that the shape of the hydrogel after compression has not undergone plastic deformation. But the compressive stress of the hydrogel is not as good as that of the hydrogel in Example 1. The drug release experiment in Example 1 was repeated using the hydrogel prepared in Example 2.

Embodiment 3

[0034] A preparation method of pH-responsive high-strength conductive hydrogel is carried out in the following steps:

[0035] (1) Dissolve γ-polyglutamic acid in a beaker containing an aqueous solution at a mass concentration of 5wt%, place the beaker on a magnetic stirrer and stir evenly until it is completely dissolved to obtain an aqueous solution of γ-polyglutamic acid as the first A reaction solution; the molecular weight of γ-polyglutamic acid is 200,000-2 million units.

[0036] (2) Then slowly add γ-(2,3-glycidoxy)propyltrimethoxysilane to the first reaction solution while stirring, and stir evenly to obtain the second reaction solution; γ-(2, The mass ratio of 3-glycidoxy)propyltrimethoxysilane to the first reaction solution is 1:11;

[0037] (3) Mix and react ethyl orthosilicate with water to obtain a hydrolyzed aqueous solution of ethyl orthosilicate; during hydrolysis, the mass ratio of ethyl orthosilicate to water is 1:1, and at the same time add 0.1% of the mas...

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Abstract

The invention relates to a preparation method and application of pH-response-type high-strength conductive hydrogel, and belongs to the technical field of biology. The preparation method comprises thesteps: 5-20 wt% of a gamma-polyglutamic acid aqueous solution is prepared, and first reaction liquid is obtained; then gamma-(2,3-epoxypropoxy)propyltrimethoxysilane is added, and after full and evenstirring, second reaction liquid is obtained; and hydrolytic ethyl orthosilicate is added into the second reaction liquid to adjust the cross-linking degree of the hydrogel, and thus the pH-response-type high-strength conductive hydrogel is obtained. The hydrogel prepared through the method has high water absorption, adjustable mechanical properties, good drug loading capacity, good pH-adjustable-and-controllable drug release behavior and good electrical conductivity and biocompatibility; and the hydrogel is short in preparation time, simple in method and low in energy consumption, and can bewidely applied to the aspects such as drug carriers, wound dressings and biosensing.

Description

technical field [0001] The invention relates to a polymer biomedical material, in particular to a preparation method and application of a conductive hydrogel. Background technique [0002] Polyglutamic acid (γ-PGA), which is a water-soluble, biodegradable, non-toxic biopolymer produced by microbial fermentation. The γ-PGA hydrogel material with three-dimensional network crosslinking can be formed by crosslinking methods such as chemical crosslinking agent and ray irradiation. γ-PGA hydrogel materials have good biocompatibility, water retention and electrical conductivity, and can be used as medical carriers, wound dressings, cosmetics, biosensing, etc. [0003] Chinese invention patent CN101891954A discloses a preparation method of polyglutamic acid hydrogel, its publication date: 20101124, the method uses polyglutamic acid as the main raw material, ethylene glycol diglycidyl ether as the crosslinking agent, and the reaction process Adjust the pH value of the system at reg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L77/04C08K5/5435C08K5/5415A61K9/06A61K47/34A61L26/00
CPCC08J3/075A61K9/06A61K47/34A61L26/008A61L26/0019A61L26/0061A61L26/009C08J2377/04C08K5/5435C08K5/5415C08L77/04Y02A50/30
Inventor 高强张晨阳高春霞
Owner YANGZHOU UNIV
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