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A hemangioma gel containing amphiphilic polymer and its preparation method

A technology of amphiphilic polymers and infantile hemangiomas, applied in the field of hemangioma gel containing amphiphilic polymers and its preparation, can solve the problems of unfavorable infant patients, adverse reactions, and high blood drug concentration. Achieve the effect of enhancing anti-virus ability, convenient use, and lowering blood pressure

Active Publication Date: 2022-04-26
AFFILIATED CHILDRENS HOSPITAL OF CAPITAL INST OF PEDIATRICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese patents CN102871956B and CN106727278B respectively disclose propranolol gel and timolol maleate gel for treating hemangioma gel and their preparation methods, but these preparations all contain azone-like transdermal Osmotic agent, will cause blood concentration is too high, and cause systemic adverse reactions, not conducive to the use of infants and young children

Method used

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  • A hemangioma gel containing amphiphilic polymer and its preparation method
  • A hemangioma gel containing amphiphilic polymer and its preparation method
  • A hemangioma gel containing amphiphilic polymer and its preparation method

Examples

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Effect test

Embodiment 1

[0028] The preparation of amphiphilic polymer NVP-maleic acid monodocosanol monoester copolymer is carried out according to the following steps:

[0029] (1) Mix maleic anhydride and docosanol at a molar ratio of 1:0.7, stir magnetically at 50°C, react for 4 hours, cool to room temperature, and use methanol and water at a volume ratio of 1:5. 100mL, rinse the reaction product, remove excess unreacted maleic anhydride, and dry to obtain behenyl maleate;

[0030] (2) Get 0.005g initiator dimethyl azobisisobutyrate, N-vinylpyrrolidone 1g and step (1) gained docosanol monoester maleate 1g, add n-heptane 100mL, in nitrogen Protection, mechanical stirring at 50°C, white precipitate NVP-maleic acid monodocosanol monoester copolymer was obtained.

Embodiment 2

[0032] (1) Mix maleic anhydride and docosanol at a molar ratio of 1.3:1, stir magnetically at 80°C, react for 7 hours, cool to room temperature, and use methanol and water at a volume ratio of 5:9. 260mL, rinse the reaction product, remove excess unreacted maleic anhydride, and dry to obtain behenyl maleate;

[0033](2) Get 0.1g initiator azobisisobutyrate dimethyl ester, N-vinylpyrrolidone 8g and step (1) gained behenyl alcohol monoester 4g, add n-heptane 400mL, in nitrogen Protection, mechanical stirring at 90°C, white precipitate NVP-maleic acid monodocosanol monoester copolymer was obtained.

Embodiment 3

[0035] (1) Mix maleic anhydride and docosanol at a molar ratio of 1.2:0.9, stir magnetically at 50-80°C, react for 6 hours, cool to room temperature, and mix methanol and water at a volume ratio of 3:7 Mixed solution 150mL, wash reaction product, remove excess unreacted maleic anhydride, dry, obtain behenyl maleate;

[0036] (2) get 0.06g initiator dimethyl azobisisobutyrate, N-vinylpyrrolidone 5g and step (1) gained behenyl maleate monoester 2.5g, add n-heptane 250mL, in Nitrogen protection, mechanical stirring at 75°C, a white precipitate of NVP-maleic acid monodocosanol monoester copolymer was obtained.

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Abstract

The invention provides a hemangioma gel containing an amphiphilic polymer and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. The invention provides a hemangioma gel containing an amphiphilic polymer, which is composed of propranolol or timolol maleate, NVP-maleic acid monodocosanol monoester copolymer, Tween-80 , sodium lauryl sulfate, propylene glycol, silicone oil, vaseline, chlorobutanol and purified water; the hemangioma gel has the characteristics of simple preparation, convenient use, quick onset, long acting time, and remarkable therapeutic effect. NVP ‑Docosanol monoester maleate copolymer increases the action time of the drug, improves the biocompatibility of the drug, has the advantages of slow and controlled release, and reduces the use of transdermal accelerators; the hemangioma coagulation agent of the present invention The glue is suitable for industrialized large-scale production and is used for treating infantile hemangioma.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a hemangioma gel containing an amphiphilic polymer and a preparation method thereof. Background technique [0002] Hemangioma (Infantile Henangiomas, IH) is a congenital benign tumor composed of vascular tissue. It is the most common in infants and young children. The incidence rate is as high as 10% in children under 1 year old, and up to 30% in premature infants. It is proliferative phase, regression phase, and regression completion phase. Generally, the proliferative phase is within 1 year old, and then it will gradually transition to the regression phase. The tumor tissue that regresses is replaced by fat and fibrous tissue, and the skin on the surface of the tumor is loose or scarred. Although 85%-90% of IH can spontaneously regress at the age of 7-10, some severe hemangiomas will persist permanently, even affecting the breathing and vision of infants and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K47/34A61K31/138A61K31/5377A61P35/00C08F226/10C08F222/16
CPCA61K9/06A61K47/34A61K31/138A61K31/5377A61P35/00C08F226/10C08F222/16
Inventor 狄奇牛振喜胡靖刘景陈志平
Owner AFFILIATED CHILDRENS HOSPITAL OF CAPITAL INST OF PEDIATRICS
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